WNT signalling pathways as therapeutic targets in cancer
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...Therefore, suppressing the Wnt pathway became an attractive route for therapeutic intervention (Anastas and Moon, 2013)....
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Cites background from "WNT signalling pathways as therapeu..."
...Mechanistically, Rho-GTPases mediate the actions ofGPCRs onYAPandTAZ....
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...Gα12/13- andGαq/11-coupled GPCRs activate Rho-GTPases, which in turn inactivate LATS1/2 by a yet unknown mechanism that is dependent on F-actin assembly (Yu et al. 2012)....
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...Soluble factors and G-protein-coupled receptors (GPCRs) Tissue growth requires nutrients as well as hormonal signals via autocrine, paracrine, and endocrine mechanisms....
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...Amajor breakthrough in the Hippo pathway came with the discovery that diffusive molecules, such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), activate and stabilize YAP and TAZ through their GPCRs, LPA receptor (LPAR) and S1P receptor (S1PR) (Yu et al. 2012)....
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...GPCRs are the largest family of the plasma membrane receptors and mediate the actions of hundreds of extracellular molecules (Lap- pano and Maggiolini 2011)....
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References
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