Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis
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193 citations
Cites background from "Wogonin protects against cisplatin-..."
...RIPK1 and 3 [94,111,136,137], pMLKL, and cleaved caspase 8 are upregulated in response to cisplatin administration [138]....
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...A novel herbal compound, wogonin, protects against AKI, possibly through a physical interaction with the ATP-binding pocket of RIPK1 to inhibit its pro-necrotic effects [138]....
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Cites background from "Wogonin protects against cisplatin-..."
...It has been found that the response of many cells to oxidative stress involves signaling proteins which act through the antioxidant response element (ARE) and the transcription factor erythrocyte 2-associated factor 2 (Nrf2) [9], which plays an important role in the regulation of the phase II gene....
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73 citations
Cites background or methods from "Wogonin protects against cisplatin-..."
...The sequences of primers, including mouse and human, were used as described previously [21-23]....
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...Our team recently found that by binding to the ATP-binding pocket of RIPK1, wogonin prevents cisplatin-induced necroptosis and renal injury [22]....
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References
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