World Congress Integrative Medicine & Health 2017: Part one
TL;DR: This work is presented at the I1 World Congress for Integrative Medicine & Health 2017 a global forum for exploring the future of comprehensive patient care in Washington, DC.
Abstract: I1 World Congress for Integrative Medicine & Health 2017 A global forum for exploring the future of comprehensive patient care Benno Brinkhaus, Torkel Falkenberg, Aviad Haramati, and Stefan N. Willich Institute for Social Medicine, Epidemiology and Health Economics, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Neurobiology Care Sciences and Society, Division of Nursing, Research Group Integrative Care, Karolinska Institutet, Stockholm, Sweden; I C – The Integrative Care Science Center, Järna, Sweden; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Medical Center, Washington, DC, USA; Department of Medicine, Georgetown University Medical Center, Washington, DC, USA BMC Complementary and Alternative Medicine 2017, 17(Suppl 1):I1
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TL;DR: Cardiorespiratory training and, to a lesser extent, mixed training reduce disability during or after usual stroke care; this could be mediated by improved mobility and balance.
Abstract: Stroke patients have impaired physical fitness and this may exacerbate their disability. It is not known whether improving physical fitness after stroke reduces disability. Objectives The primary aims were to establish whether physical fitness training reduces death, dependence and disability after stroke. The secondary aims included an investigation of the effects of fitness training on secondary outcome measures (including, physical fitness, mobility, physical function, health and quality of life, mood and the incidence of adverse events). Randomised controlled trials were included when an intervention represented a clear attempt to improve either muscle strength and/or cardiorespiratory fitness, and whose control groups comprised either usual care or a non-exercise intervention. A total of 12 trials were included in the review. No trials reported death and dependence data. Two small trials reporting disability showed no evidence of benefit. The remaining available secondary outcome data suggest that cardiorespiratory training improves walking ability (mobility). Observed benefits appear to be associated with specific or 'task-related' training.
708 citations
TL;DR: In this paper, the amount of phenols and flavonoid compounds in these natural products, their antioxidant activities and the bonds present by FTIR was analyzed, which revealed the presence of active compounds in all drug samples.
Abstract: Natural products are used in wound healing in order to prevent infection. Propolis is a well known antimicrobial with phenolic compounds and flavonoid content which vary according to the propolis origin. Besides propolis (from both Brazilian and UK sources), pomegranate, dragon's blood and sage are possible antimicrobials to be used in biomaterials. The goal of this work was to analyze the amount of phenols and flavonoid compounds in these natural products, their antioxidant activities and the bonds present by FTIR. The FTIR analysis revealed the presence of active compounds in all drug samples. The phenols quantification showed that Brazilian propolis was rich in phenols compared to the other drugs, followed by pomegranate and UK propolis. UK propolis was the most rich in flavonoids, which is expected on account of its origin. Pomegranate, UK propolis and Dragon's blood presented the highest antioxidant activity. All samples presented antioxidant activity > 82%.
243 citations
TL;DR: Experimental studies of nerve stimulation are providing new information on the functional organization of the nervous system to control inflammation and its clinical implications in infectious and inflammatory disorders, which may allow the design of novel non-invasive techniques for nerve stimulation to help to control immune and organ functions.
Abstract: Neuronal stimulation is an emerging field in modern medicine to control organ function and re-establish physiological homeostasis during illness. Transdermal nerve stimulation with electroacupuncture is currently endorsed by the World Health Organization (WHO) and the National Institutes of Health (NIH), and is used by millions of people to control pain and inflammation. Recent advances in electroacupuncture may permit activation of specific neuronal networks to prevent organ damage in inflammatory and infectious disorders. Experimental studies of nerve stimulation are also providing new information on the functional organization of the nervous system to control inflammation and its clinical implications in infectious and inflammatory disorders. These studies may allow the design of novel non-invasive techniques for nerve stimulation to help to control immune and organ functions.
92 citations
TL;DR: Pectin is a natural biopolymer derived from various plant sources and its activity is driven by functional groups and its affinity of pectin and chemical interactions of the active sites to chemicals in media determines fate of adjuvant molecules.
Abstract: Pectin is natural biopolymer derived from various plant sources and its activity is driven by functional groups. Affinity of pectin and chemical interactions of the active sites to chemicals in media determines fate of adjuvant molecules. Pectin is appropriate co-polymer in modulation of drawbacks of other biopolymers such as low glass transition temperature, low water solubility, and susceptibility to human digestive tract. However, functionality of pectin is improved by its optimized complexation with other chemicals especially in food packaging and tissue engineering. In the last decade, several technical and health-related functions of pectin have been studied through which some products designed and marketed progressively. Pectin-based formulations were commercialized in food, medicine, and radioprotection sectors. It is also advised for alleviation of constipation symptoms. Cost-effectiveness of this multifunctional biopolymer compared to the others that are currently used, has introduced it as a potential alternative for the next years.
78 citations
TL;DR: This review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research, which will be important for future directed research and may allow researchers to tackle the next big challenge in mangOSTeen study: drug development and human applications.
Abstract: Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and is rich in beneficial compounds such as xanthones. Mangosteen originally been used in various folk medicines to treat diarrhea, wounds, and fever. More recently, it had been used as a major component in health supplement products for weight loss and for promoting general health. This is perhaps due to its known medicinal benefits, including as anti-oxidant and anti-inflammation. Interestingly, publications related to mangosteen have surged in recent years, suggesting its popularity and usefulness in research laboratories. However, there are still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the years of 2016 to 2018 which focus on several aspects including the latest findings on the compound composition of mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including in anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study: drug development and human applications.
55 citations
References
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TL;DR: The TIDieR checklist and guide should improve the reporting of interventions and make it easier for authors to structure accounts of their interventions, reviewers and editors to assess the descriptions, and readers to use the information.
Abstract: Without a complete published description of interventions, clinicians and patients cannot reliably implement interventions that are shown to be useful, and other researchers cannot replicate or build on research findings. The quality of description of interventions in publications, however, is remarkably poor. To improve the completeness of reporting, and ultimately the replicability, of interventions, an international group of experts and stakeholders developed the Template for Intervention Description and Replication (TIDieR) checklist and guide. The process involved a literature review for relevant checklists and research, a Delphi survey of an international panel of experts to guide item selection, and a face to face panel meeting. The resultant 12 item TIDieR checklist (brief name, why, what (materials), what (procedure), who provided, how, where, when and how much, tailoring, modifications, how well (planned), how well (actual)) is an extension of the CONSORT 2010 statement (item 5) and the SPIRIT 2013 statement (item 11). While the emphasis of the checklist is on trials, the guidance is intended to apply across all evaluative study designs. This paper presents the TIDieR checklist and guide, with an explanation and elaboration for each item, and examples of good reporting. The TIDieR checklist and guide should improve the reporting of interventions and make it easier for authors to structure accounts of their interventions, reviewers and editors to assess the descriptions, and readers to use the information.
5,237 citations
TL;DR: The chapter explores the possibility that CSK tensegrity may also provide a mechanical basis for cell locomotion as well as a structural mechanism for coupling mechanical and chemical signaling pathways inside the cell.
Abstract: Publisher Summary This chapter focuses on the role of the intracellular cytoskeleton (CSK) in cell shape determination and tissue morphogenesis. The role of mechanical changes in the CSK during embryological development is reviewed. The chapter focuses on the mechanism by which mechanical forces are transmitted across the cell surface and through the CSK, as well as how they regulate cell shape. An analysis of the biomechanical basis of cell shape control addresses two central questions: (1) how do changes in mechanical forces alter CSK organization, and (2) how do changes in CSK structure regulate cell growth and function. The results from recent studies showing that the CSK can respond directly to mechanical stress are also reviewed. The particular type of mechanical response that living cells exhibit is consistent with a theory of CSK architecture that is based on tensional integrity and is known as “tensegrity”. Inherent to the tensegrity model is an efficient mechanism for integrating changes in structure and function at the tissue, cell, nuclear, and molecular levels. The chapter explores the possibility that CSK tensegrity may also provide a mechanical basis for cell locomotion as well as a structural mechanism for coupling mechanical and chemical signaling pathways inside the cell.
439 citations
"World Congress Integrative Medicine..." refers background or methods in this paper
...This was further investigated in a dose-escalating trial [4], and then in a randomised controlled trial [5]....
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...We propose our rationale for the choice of foods and their distribution during the day, based upon the best research in the field of plant-derived preparations, such as pomegranate seed oil[1], grape skin extract [2], blood orange extract [3] barley b-glucan [4], anthocyanins from cherries [5], and green tea (2)-epigallocatechin-3 [6]....
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...Efforts to stimulate cultural activities should start in childhood [5]....
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Journal Article•
TL;DR: What are the effects of nonsurgical and surgical treatments for osteoarthritis of the knee?
Abstract: What are the effects of nonsurgical and surgical treatments for osteoarthritis of the knee?
384 citations
TL;DR: This work confirms that mechanical forces generated in the cytoskeleton of individual cells and exerted on ECM scaffolds, play a critical role in the sculpting of the embryo.
Abstract: Twenty years ago, we proposed a model of developmental control based on tensegrity architecture, in which tissue pattern formation in the embryo is controlled through mechanical interactions between cells and extracellular matrix (ECM) which place the tissue in a state of isometric tension (prestress). The model proposed that local changes in the mechanical compliance of the ECM, for example, due to regional variations in basement membrane degradation beneath growing epithelium, may result in local stretching of the ECM and associated adherent cells, much like a "run-in-a-stocking". Cell growth and function would be controlled locally though physical distortion of the associated cells, or changes in cytoskeletal tension. Importantly, experimental studies have demonstrated that cultured cells can be switched between different fates, including growth, differentiation, apoptosis, directional motility and different stem cell lineages, by modulating cell shape. Experiments in whole embryonic organ rudiments also have confirmed the tight correlation between basement membrane thinning, cell tension generation and new bud and branch formation during tissue morphogenesis and that this process can be inhibited or accelerated by dissipating or enhancing cytoskeletal tension, respectively. Taken together, this work confirms that mechanical forces generated in the cytoskeleton of individual cells and exerted on ECM scaffolds, play a critical role in the sculpting of the embryo.
350 citations
"World Congress Integrative Medicine..." refers background in this paper
...We propose our rationale for the choice of foods and their distribution during the day, based upon the best research in the field of plant-derived preparations, such as pomegranate seed oil[1], grape skin extract [2], blood orange extract [3] barley b-glucan [4], anthocyanins from cherries [5], and green tea (2)-epigallocatechin-3 [6]....
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TL;DR: The existing evidence suggests that acupuncture may play a role in the treatment of knee OA and future research should define an optimal acupuncture treatment, measure quality of life, and assess acupuncture combined with other modalities.
Abstract: Objective
To evaluate trials of acupuncture for osteoarthritis (OA) of the knee, to assess the methodologic quality of the trials and determine whether low-quality trials are associated with positive outcomes, to document adverse effects, to identify patient or treatment characteristics associated with positive response, and to identify areas of future research.
Methods
Eight databases and 62 conference abstract series were searched. Randomized or quasi-randomized trials of all languages were included and evaluated for methodologic quality using the Jadad scale. Outcomes were pain, function, global improvement, and imaging. Data could not be pooled; therefore, a best-evidence synthesis was performed to determine the strength of evidence by control group. The adequacy of the acupuncture procedure was assessed by 2 acupuncturists trained in treating OA and blinded to study results.
Results
Seven trials representing 393 patients with knee OA were identified. For pain and function, there was limited evidence that acupuncture is more effective than being on a waiting list for treatment or having treatment as usual. For pain, there was strong evidence that real acupuncture is more effective than sham acupuncture; however, for function, there was inconclusive evidence that real acupuncture is more effective than sham acupuncture. There was insufficient evidence to determine whether the efficacy of acupuncture is similar to that of other treatments.
Conclusion
The existing evidence suggests that acupuncture may play a role in the treatment of knee OA. Future research should define an optimal acupuncture treatment, measure quality of life, and assess acupuncture combined with other modalities.
286 citations