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World malaria report

About: The article was published on 2005-01-01 and is currently open access. It has received 5145 citations till now. The article focuses on the topics: Malaria & Indoor residual spraying.
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Journal ArticleDOI
Rafael Lozano1, Mohsen Naghavi1, Kyle J Foreman2, Stephen S Lim1  +192 moreInstitutions (95)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.

11,809 citations

Journal ArticleDOI
TL;DR: As the authors move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented.

1,024 citations

Journal ArticleDOI
20 May 2010-Nature
TL;DR: Chemical structures and associated data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host–pathogen interaction related targets.
Abstract: Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease.

953 citations

References
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TL;DR: This work examines malaria-related mortality under different circumstances and discusses implications for the management of malaria in these settings and emphasizes the power of rapid case treatment to save lives at risk under virtually all circumstances of malaria transmission.

74 citations

Journal Article
Meek1
TL;DR: Malaria epidemiology from 1983 to 1985 in displaced Khmers living in camps on the Thai-Kampuchean border was studied and Epidemiological information has been more useful for planning than for evaluating control measures.
Abstract: Malaria epidemiology from 1983 to 1985 in displaced Khmers living in camps on the Thai-Kampuchean border was studied for planning and evaluation of control measures. The annual parasite incidence per 1000 people fell from 359 in 1983 and 350 in 1984 to 116 in 1985. Incidence varied by camp according to the suitability of the habitat for the vectors. Camps with high incidence had a higher ratio of Plasmodium falciparum to P. vivax, a higher mortality rate, especially in young children and sometimes pregnant women, but a lower case fatality rate than camps with low incidence. Transmission occurred year round, but peaked in the rainy season in 1983 and 1984. In 1985 there was a steady decline in incidence, largely owing to evacuation of many camps away from forested areas. Mortality rates per 100,000 people were 62, 77 and 28 and case fatality rates 0.41, 0.31 and 0.42% in 1983, 1984 and 1985 respectively. The case fatality rate for cerebral malaria was 21 to 26%. Epidemiological information has been more useful for planning than for evaluating control measures.

33 citations

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