X-inactivation profile reveals extensive variability in X-linked gene expression in females
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6,125 citations
Additional excerpts
...We also examined two gene sets containing genderspecific genes in detail: genes that escape X-inactivation in female samples [53] and genes that are located on the male-specific region of the Y chrosomome [54]....
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4,475 citations
Cites background from "X-inactivation profile reveals exte..."
...[44] Carrel L, Willard HF: X-inactivation profile reveals extensive variability in X-linked gene expression in females....
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...The top gene is XIST, which is a key player in X-inactivation and is known to be expressed at meaningful levels only in females....
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...We also examined 46 X-chromosome genes that have been reported to escape X-inactivation [44, 43]....
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2,101 citations
Cites methods from "X-inactivation profile reveals exte..."
...For the X inactivation analysis, we matched X-linked promoters to the genes assayed in a recent comprehensive X inactivation profile in human cell...
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1,629 citations
1,464 citations
References
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"X-inactivation profile reveals exte..." refers background in this paper
...3 (Supplementary Table 2), 267 were excluded from analysis because (1) they mapped to multiple locations, (2) they were computationally-predicted proteins that lacked significant expressed-sequence-tag (EST) support, or (3) they were transcripts with restricted expression patterns; for example, 10% of genes on the X chromosome are cancer-testis antigen genes that are not expressed in fibroblasts(13) (Supplementary Table 2 and Supplementary Note 1)....
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2,062 citations
"X-inactivation profile reveals exte..." refers result in this paper
...This frequency of expressed transcripts (71%) is consistent with microarray studies of fibroblast...
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2,022 citations