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Open AccessJournal ArticleDOI

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
- Vol. 380, Iss: 9859, pp 2163-2196
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TLDR
Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
About: 
This article is published in The Lancet.The article was published on 2012-12-15 and is currently open access. It has received 7021 citations till now. The article focuses on the topics: Years of potential life lost & Global health.

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Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

Courtney M. Mazur, +18 more
- 05 Nov 2019 - 
TL;DR: Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis, likely via its effects on PLR, and suggests a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis.
Journal ArticleDOI

ITI-007 for the Treatment of Schizophrenia: A 4-Week Randomized, Double-Blind, Controlled Trial

Jeffrey A. Lieberman, +7 more
- 15 Jun 2016 - 
TL;DR: Primary analyses indicated that ITI-007 improved negative and depression symptoms and might have expanded therapeutic efficacy in comparison with current antipsychotic drugs in this trial.
Journal ArticleDOI

Health metrics for helminth infections.

Charles H. King
- 01 Jan 2015 - 
TL;DR: Gaps in current knowledge of disease burden are identified, and interim approaches to disease burden assessment are discussed, and Gap-adjusted Life Year and Quality-Adjusted Life Year metrics are discussed.
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Health behaviour change theories: contributions to an ICF-based behavioural exercise therapy for individuals with chronic diseases

Wolfgang Geidl, +2 more
- 28 Nov 2014 - 
TL;DR: The usefulness of theory-based integrative research in the field of exercise therapy is highlighted, explicit methods and contents for physical therapists to promote PA behaviour are offered, and the International Classification of Functioning-based concept of a behavioural exercise therapy (BET) is introduced.
Journal ArticleDOI

The projected effect of risk factor reduction on major depression incidence: a 16-year longitudinal Canadian cohort of the National Population Health Survey.

Xiangfei Meng, +1 more
- 01 Apr 2014 - 
TL;DR: Public health campaigns targeted at significant modifiable risk factors could have a profound effect on future depression incidence, and prevention trials are needed to directly evaluate the effect of single and/or multiple risk factors modification on depression incidence.
References
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Journal ArticleDOI

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Rafael Lozano, +195 more
- 15 Dec 2012 - 
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.

The Global Burden of Disease Study

Christopher J L Murray, +1 more
Book

Cancer Incidence in Five Continents

Freddie Bray, +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

Ronald C. Kessler, +8 more
- 18 Jun 2003 - 
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
Book

The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.

Christopher J L Murray, +1 more
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

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