Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
Abstr Act,Patrícia Brasil,Jose Paulo Pereira,Claudia Raja Gabaglia,Luana Damasceno,Mayumi Duarte Wakimoto,Rita Maria Ribeiro Nogueira,Patricia Carvalho de Sequeira,André M. Siqueira,Liege Maria Abreu de Carvalho,Denise Cotrim da Cunha,Guilherme Amaral Calvet,Elizabeth de Souza Neves,Maria Elisabeth Lopes Moreira,Ana Elisa Rodrigues Baião,Paulo Roberto Nassar de Carvalho,Carla Janzen,Stephanie G. Valderramos,James D. Cherry,Ana Maria Bispo de Filippis,Karin Nielsen-Saines +20 more
Reads0
Chats0
TLDR
Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.Abstract:
BackgroundZika virus (ZIKV) has been linked to central nervous system malformations in fetuses. To characterize the spectrum of ZIKV disease in pregnant women and infants, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in infants. MethodsWe enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerase-chain-reaction assays. We followed women prospectively to obtain data on pregnancy and infant outcomes. ResultsA total of 345 women were enrolled from September 2015 through May 2016; of these, 182 women (53%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 6 to 39 weeks of gestation. Predominant maternal clinical features included a pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 27% had fever (short-term and low-grade). By Jul...read more
Citations
More filters
Journal ArticleDOI
Zika Virus and Birth Defects — Reviewing the Evidence for Causality
TL;DR: It is concluded that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies and needs to intensify efforts toward the prevention of adverse outcomes caused by congenital Zika virus infections.
Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
Journal ArticleDOI
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Wanwisa Dejnirattisai,Piyada Supasa,Piyada Supasa,Wiyada Wongwiwat,Alexander Rouvinski,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Thaneeya Duangchinda,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Prida Malasit,Prida Malasit,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +17 more
TL;DR: Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
Journal ArticleDOI
A Mouse Model of Zika Virus Pathogenesis
Helen M. Lazear,Jennifer Govero,Amber M. Smith,Derek J. Platt,Estefania Fernandez,Jonathan J. Miner,Michael S. Diamond +6 more
TL;DR: Ifnar1(-/-) mice sustained high viral loads in the brain and spinal cord, consistent with evidence that ZIKV causes neurodevelopmental defects in human fetuses and valuable for evaluating vaccines and therapeutics as well as understanding disease pathogenesis.
Journal ArticleDOI
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.
Jonathan J. Miner,Bin Cao,Jennifer Govero,Amber M. Smith,Estefania Fernandez,Omar H. Cabrera,Charise Garber,Michelle Noll,Robyn S. Klein,Kevin K. Noguchi,Indira U. Mysorekar,Michael S. Diamond +11 more
TL;DR: These models will facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vaccines to prevent congenital malformations and to identify ZikV within trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection route.
References
More filters
Journal ArticleDOI
Zika Virus Associated with Microcephaly
Jernej Mlakar,Miša Korva,Mateja Poljšak-Prijatelj,Jerica Mraz,Marko Kolenc,Katarina Resman Rus,Tina Vesnaver Vipotnik,Vesna Fabjan,Alenka Vizjak,Miroslav Petrovec +9 more
TL;DR: The case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil and revealed microcephaly with calcifications in the fetal brain and placenta is described.
Journal ArticleDOI
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007
Robert S. Lanciotti,Olga Kosoy,Janeen Laven,Jason O. Velez,Amy J. Lambert,Alison J. Johnson,Stephanie M. Stanfield,Mark R. Duffy +7 more
TL;DR: The full coding region nucleic acid sequence and serologic properties of the virus were identified and the virus was identified as Crimean-Congo-Wales coronavirus.
Journal ArticleDOI
Zika Virus and Birth Defects — Reviewing the Evidence for Causality
TL;DR: It is concluded that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies and needs to intensify efforts toward the prevention of adverse outcomes caused by congenital Zika virus infections.
Journal ArticleDOI
International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project
José Villar,Leila Cheikh Ismail,Cesar G. Victora,Eric O Ohuma,Eric O Ohuma,Enrico Bertino,Doug G Altman,A Lambert,Aris T. Papageorghiou,M Carvalho,Y A Jaffer,Michael G. Gravett,Manorama Purwar,I O Frederick,A. Noble,Ruyan Pang,Fernando C. Barros,Fernando C. Barros,Cameron Chumlea,Zulfiqar A Bhutta,Stephen Kennedy +20 more
TL;DR: International anthropometric standards to assess newborn size that are intended to complement the WHO Child Growth Standards and allow comparisons across multiethnic populations are developed.
Journal ArticleDOI
First report of autochthonous transmission of Zika virus in Brazil
Camila Zanluca,Vanessa Campos Andrade de Melo,Ana Luiza Pamplona Mosimann,Glauco Igor Viana dos Santos,Claudia Nunes Duarte dos Santos,Kleber Giovanni Luz +5 more
TL;DR: Phylogenetic analysis suggests that the ZikV identified belongs to the Asian clade, the first report of ZIKV infection in Brazil, and the result was confirmed by DNA sequencing.
Related Papers (5)
Zika virus outbreak on Yap Island, Federated States of Micronesia.
Mark R. Duffy,Tai-Ho Chen,W. Thane Hancock,Ann M. Powers,Jacob L. Kool,Robert S. Lanciotti,Moses Pretrick,Maria Marfel,Stacey Holzbauer,Christine Dubray,Laurent Guillaumot,Anne Griggs,Martin Bel,Amy J. Lambert,Janeen Laven,Olga I. Kosoy,Amanda J. Panella,Brad J. Biggerstaff,Marc Fischer,Edward B. Hayes +19 more
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Van-Mai Cao-Lormeau,Alexandre Blake,Sandrine Mons,Stéphane Lastère,Claudine Roche,Jessica Vanhomwegen,Timothée Dub,Laure Baudouin,Anita Teissier,P. Larre,Anne-Laure Vial,Christophe Decam,Valérie Choumet,Susan K. Halstead,Hugh J. Willison,Lucile Musset,Jean-Claude Manuguerra,Philippe Desprès,Emmanuel Fournier,Henri-Pierre Mallet,Didier Musso,Arnaud Fontanet,Arnaud Fontanet,Jean Neil,Frédéric Ghawché +24 more