Zinc Uptake by Lactic Acid Bacteria
Alan Leonardi,Simona Zanoni,Marzia De Lucia,Alberto Amaretti,Stefano Raimondi,Maddalena Rossi +5 more
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TLDR
Results provide new perspectives on the specific use of probiotics, since L. acidophilus WC 0203 could function as an organic matrix for zinc incorporation, and the bioavailability of Lactobacillus-bound zinc deserves to be investigated.Abstract:
The study aims to investigate zinc biosorption by strains of lactobacilli and bifidobacteria with a view to exploit them as organic matrixes for zinc dietary supplementation. Sixteen human strains of Lactobacillus and Bifidobacterium were assayed for zinc uptake. The minimum inhibitory concentration of zinc salts differed among the strains, but was never below 15 mmol L−1. When cultured in MRS broth containing 10 mmol L−1 ZnSO4, all the strains were capable of accumulating zinc in the range between 11 and 135 μmol g−1. The highest amount of cell-bound zinc was obtained in L. acidophilus WC 0203. pH-controlled batch cultures of this strain revealed that zinc uptake started in the growth phase, but occurred mostly during the stationary phase. Pasteurized and viable cultures accumulated similar amount of zinc, suggesting that a nonmetabolically mediated mechanism is involved in zinc uptake. These results provide new perspectives on the specific use of probiotics, since L. acidophilus WC 0203 could function as an organic matrix for zinc incorporation. The bioavailability of Lactobacillus-bound zinc deserves to be investigated to provide a future basis for optimization of zinc supplementation or fortification.read more
Citations
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The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility.
Toshiki G. Nakashige,Jules R. Stephan,Lisa S. Cunden,Megan Brunjes Brophy,Andrew J. Wommack,Brenna C. Keegan,Jason Shearer,Elizabeth M. Nolan +7 more
TL;DR: In this paper, the authors reported that human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense protein that is involved in the metal-withholding innate immune response.
The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility
Brenna C. Keegan,Jason Shearer,Toshiki G. Nakashige,Jules R. Stephan,Lisa S. Cunden,Megan Brunjes Brophy,Andrew J. Wommack,Elizabeth M. Nolan +7 more
TL;DR: The Zn(II)-His6 site of CP expands the known biological coordination chemistry of Zn (II) and provides new insight into how the human innate immune system starves microbes of essential metal nutrients.
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The comparative mechanistic aspects of Trichoderma and Probiotics: Scope for future research
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