Zygotic Genome Activation in Vertebrates.
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TLDR
Progress in understanding vertebrate ZGA dynamics in frogs, fish, mice, and humans is reviewed to explore differences and emphasize common features.About:
This article is published in Developmental Cell.The article was published on 2017-08-21 and is currently open access. It has received 262 citations till now. The article focuses on the topics: Maternal to zygotic transition.read more
Citations
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Journal ArticleDOI
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.
TL;DR: The maternal-to-zygotic transition (MZT) is defined as the transition from maternal gene expression in the oocyte to zygotic genome activation and embryonic-driven development, characterized by global DNA demethylation, chromatin remodelling, genome reorganization and substantial transcriptional changes.
Posted ContentDOI
Beyond accessibility: ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
Mette Bentsen,Philipp Goymann,Hendrik Schultheis,Anastasiia Petrova,Kathrin Klee,Annika Fust,Jens Preussner,Carsten Kuenne,Thomas Braun,Johnny Kim,Mario Looso +10 more
TL;DR: ToBIAS is presented, a comprehensive, accurate, and fast footprinting framework enabling genome-wide investigation of TF binding dynamics for hundreds of TFs simultaneously, and illustrated how to unveil complex TF dynamics during zygotic genome activation (ZGA) in both humans and mice.
Journal ArticleDOI
Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program
Mélanie A. Eckersley-Maslin,Celia Alda-Catalinas,Marloes Blotenburg,Elisa Kreibich,Christel Krueger,Wolf Reik,Wolf Reik +6 more
TL;DR: A candidate-based overexpression screen is performed, identifying developmental pluripotency-associated 2 (Dppa2) and Dppa4 as positive regulators of 2C-like cells and transcription of ZGA genes, and suggesting a model in which Dppa2/4 binding to the Dux promoter leads to Dux up-regulation and activation of the 2C+ transcriptional program, which is subsequently reinforced by Zscan4c.
Journal ArticleDOI
Metabolism in Pluripotent Stem Cells and Early Mammalian Development
TL;DR: Metabolism is discussed as a potential driver of earliest cell fate through its influence on the epigenome and gene expression in embryos and their in vitro surrogate pluripotent stem cells.
Journal ArticleDOI
Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.
Shun Hang Chan,Yin Tang,Liyun Miao,Hiba Darwich-Codore,Charles E. Vejnar,Jean-Denis Beaudoin,Damir Musaev,Juan P. Fernandez,Maria D.J. Benitez,Ariel A. Bazzini,Ariel A. Bazzini,Miguel A. Moreno-Mateos,Antonio J. Giraldez +12 more
TL;DR: It is concluded that P300 and Brd4 are sufficient to trigger genome-wide transcriptional competency by regulating histone acetylation on the first zygotic genes in zebrafish, which is critical for initiatingZygotic development and developmental reprogramming.
References
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