Age 72 he take two times insulin good to be healthy
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110 Citations | Such data demonstrated that age‐related insulin resistance is not an obligatory finding in the elderly and that healthy centenarians have a preserved insulin action compared to aged subjects. |
| Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. | |
| Intensive glycemic control using insulin therapy may be appropriate for many healthy older adults to reduce premature mortality and morbidity, improve quality of life, and reduce health care costs. | |
| However, between 4 and 14 mo, twofold higher plasma insulin levels were required to maintain similar HGP, suggesting that hepatic insulin resistance develops with age. | |
| We conclude that the deterioration in glucose tolerance that occurs in healthy elderly subjects is due to a decrease in both insulin secretion and action with the severity of the defect in insulin action being explained by the degree of fatness rather than age per se. | |
209 Citations | Studies in healthy humans and in those with diabetes mellitus show that consumption of high amounts of food-related AGEs is a determinant of insulin resistance and inflammation and that AGE restriction improves both. |
54 Citations | However, steady‐state insulin levels during the insulin‐clamp period were higher in the older subjects, suggesting that age leads to an impairment in insulin catabolism; thus it is likely that the impairment of in vivo insulin action with age was underestimated. |
24 Citations | However, insulin resistance with age is not a constant finding and other mechanism(s) has (have) to be involved in old individuals with impaired glucose tolerance and normal tissue insulin sensitivity. |
179 Citations | Thus, in healthy older men up to the age of 73 yr, insulin sensitivity and glucose tolerance are affected primarily by the regional body fat distribution, not age, obesity, or VO2max. |
| Adiposity and fitness continue to be significant predictors of insulin sensitivity into old age, with abdominal obesity being the most important single factor. |
Related Questions
Why does age contribute to type 2 diabetes?5 answersAge contributes to type 2 diabetes due to various factors identified in the research. Studies show that aging is associated with increased risk for type 2 diabetes, characterized by reduced insulin sensitivity and secretion. Mitochondrial dynamics play a critical role in maintaining cellular metabolic homeostasis, and dysregulation of these dynamics has been linked to age-associated type 2 diabetes, leading to β-cell dysfunction and insulin resistance. Additionally, aging impacts β-cell glucose metabolism, resulting in hyperactive glycolysis, compromised cellular identity, and β-cell dysfunction, which are shared phenotypes with diabetic mouse models. The prevalence of type 2 diabetes significantly increases with age across different BMI ranges, highlighting the impact of aging on diabetes risk independent of obesity.
Are diabetes type 2 only develops in people over age 45?5 answersDiabetes type 2 (T2DM) is not exclusive to individuals over 45 years old. Research shows that T2DM can develop in young people aged 18-45, with a more aggressive course and higher risks of complications. Additionally, a study on Chinese T2DM patients revealed that the age of onset significantly impacts the development of diabetic retinopathy (DR), with the risk being highest in those aged 31-45 years. Furthermore, individuals diagnosed with T2DM at a younger age exhibit distinct clinical characteristics, such as higher BMI, adverse lipid profiles, and faster deterioration in glycemic control, indicating a more pathogenic condition compared to late-onset T2DM. Therefore, T2DM can affect individuals of various age groups, emphasizing the importance of early detection and tailored care approaches for better outcomes.
How does agedo not affect the progression of type 2 diabetes?5 answersOlder age does affect the progression of type 2 diabetes. Individuals who develop type 2 diabetes at a younger age have a more adverse lipid profile, higher HbA1c levels, and a faster deterioration in glycaemic control compared to those who develop diabetes later in life. Additionally, younger individuals diagnosed with type 2 diabetes have a higher BMI at diagnosis and during follow-up, as well as higher triacylglycerol levels and lower HDL-cholesterol levels. These differences in disease characteristics between age groups suggest that early-onset type 2 diabetes may be a more pathogenic condition than late-onset disease. Furthermore, the use of self-monitoring of blood glucose (SMBG) is associated with a better clinical outcome in both age groups. Therefore, age plays a significant role in the progression and management of type 2 diabetes.
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