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Are free radicals toxic to neurons? 

Radical
In vivo
Oxidative stress
Trolox
Antioxidant

Answers from top 9 papers

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Papers (9)Insight
Open access•Journal Article•DOI
Oxidative injury of synapse and alteration of antioxidative defense systems in rats, and its prevention by vitamin E.
Shiro Urano, Yuki Asai, Shinobu Makabe, Mitsuyoshi Matsuo, Naotaka Izumiyama, Koichiro Ohtsubo, Toyoshige Endo 
01 Apr 1997-FEBS Journal
99 Citations
These results suggest that free radicals derived from oxygen may attack nerve terminals and peroxidize the plasma membrane.
Journal Article•DOI
Free radical scavenging by brain homogenate: Implication to free radical damage and antioxidant defense in brain
A. Mori, Jiankang Liu, Xiaoyan Wang, Motoko Kawai 
01 Mar 1994-Neurochemistry International
21 Citations
The ability of brain homogenate to scavenge free radicals implies that brain damage can be induced by free radicals since they are known to react virtually with any type of molecule such as nucleic acids, membrane lipids, and proteins in the brain.
Journal Article•DOI
Oxidative stress hypothesis in alzheimer's disease
William R. Markesbery
01 Jan 1997-Free Radical Biology and Medicine
2.1K Citations
Overall, these studies indicate that free radicals are possibly involved in the pathogenesis of neuron death in AD.
Open access•Journal Article•DOI
Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons.
Runar Almaas, Ola Didrik Saugstad, David E Pleasure, Terje Rootwelt 
01 Feb 2002-Pediatric Research
19 Citations
We conclude that oxygen and glucose deprivation causes a moderate increase in the formation of free radicals in NT2-N neurons that can be inhibited by antioxidants and by blocking of the N-methyl-d-aspartate–glutamate receptor.
Open access•Journal Article•DOI
Inhibitory action of antioxidants (ascorbic acid or α-tocopherol) on seizures and brain damage induced by pilocarpine in rats
Adriana da Rocha Tomé, Paulo Michel Pinheiro Ferreira, Rivelilson Mendes de Freitas 
01 Jun 2010-Arquivos De Neuro-psiquiatria
50 Citations
These findings suggested that free radicals can be produced during brain damage induced by seizures.
Journal Article•DOI
Free Radical Trapping as a Therapeutic Approach to Neuroprotection in Stroke: Experimental and Clinical Studies with NXY-059 and Free Radical Scavengers
Green Ar, Ashwood T 
31 Mar 2005-Current Drug Targets - Cns & Neurological Disorders
106 Citations
Removal of pathologically produced free radicals is therefore a viable approach to neuroprotection.
Open access•Journal Article•DOI
Evolution of the Knowledge of Free Radicals and Other Oxidants.
Sergio Di Meo, Paola Venditti 
23 Apr 2020-Oxidative Medicine and Cellular Longevity
133 Citations
Moreover, evidence was obtained that when, in the living organism, free radicals are not neutralized by systems of biochemical defences, many pathological conditions develop.
Journal Article•DOI
The role of free radicals and antioxidants: How do we know that they are working?
Michael J. Thomas
01 Jan 1995-Critical Reviews in Food Science and Nutrition
89 Citations
Generation of free radicals in vivo also may be the result of exposure to certain chemical agents present in the environment.
Open access•Journal Article•DOI
Free Radicals in Licorice-Flavored Sweets Can Be Detected Noninvasively Using Low Frequency Electron Paramagnetic Resonance after Oral Administration to Mice
Bernard Gallez, Christine Baudelet, René Debuyst 
01 Jul 2000-Journal of Nutrition
12 Citations
This study is the first report demonstrating noninvasively the presence of free radicals in vivo coming from food.

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