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Are miRNAs involved in the progression and metastasis of head and neck cancer? 

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MicroRNAs (miRNAs) play a significant role in the progression and metastasis of head and neck cancer (HNC) . They have been shown to impact various characteristics of HNC, including angiogenesis, invasion, metastasis, cell cycle, proliferation, and apoptosis . miRNAs can control the expression of genes involved in HNC pathogenesis and signaling networks, such as the WNT/β-catenin pathway, PTEN/Akt/mTOR pathway, TGFβ, and KRAS mutations . Additionally, miRNAs can affect the response of HNC to treatments like radiation and chemotherapy . Studies have also demonstrated that circular RNAs (circRNAs), which primarily function through miRNA sponges, are involved in HNC metastasis . Alterations in the expression of specific miRNAs have been identified as potential biomarkers for the diagnosis, prognosis, and therapeutic targeting of HNC . Overall, miRNAs have emerged as important regulators of HNC progression and metastasis, offering potential avenues for improved diagnosis and treatment strategies.

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Yes, miRNAs are involved in the progression and metastasis of head and neck squamous cell carcinoma (HNSCC). The paper discusses the diagnostic and prognostic values of miRNAs in the recurrence and metastasis of HNSCC.
The paper suggests that miRNAs hsa-miR-17-5p, hsa-miR-140-5p, and hsa-miR-874-3p may work as important regulators of VEGFA, KRAS, and NFE2L2 signaling pathways in head and neck cancer, indicating their potential involvement in cancer progression and metastasis.
Yes, miRNA alterations correlate with the progression and metastasis of head and neck squamous cell carcinoma (HNSCC).
Yes, miRNAs are involved in the progression and metastasis of head and neck cancer. The paper mentions that circular RNAs (circRNAs) primarily function through miRNA sponges, indicating the regulatory relationship between circRNAs and HNC metastasis.
Yes, miRNAs are involved in the progression and metastasis of head and neck cancer. The paper states that miRNAs play a role in angiogenesis, invasion, metastasis, cell cycle, proliferation, and apoptosis, which are all characteristics associated with the progression and metastasis of head and neck cancer.

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Can miRNAs be used to detect cancer at an early stage?5 answersMicroRNAs (miRNAs) have emerged as potential biomarkers for the early detection of cancer, including lung cancer and bladder cancer. In the context of lung cancer, miRNAs have been shown to be stable, abundant, and easily detectable in tumor tissues and body fluids, making them suitable for diagnosis and treatment. Studies have compared different statistical methods for identifying differentially expressed miRNAs (DE-miRNAs) in large datasets, and computational mathematics/statistics have been used to improve miRNA analysis and identify clinically applicable biomarkers for lung cancer. In the case of bladder cancer, a three-miRNA signature (miR-27b-3p, miR-381-3p, and miR-451a) has been constructed with high sensitivity and specificity for the early diagnosis of bladder cancer, suggesting the potential of miRNAs as non-invasive biomarkers. Overall, these findings suggest that miRNAs can be used to detect cancer at an early stage, providing opportunities for improved outcomes and non-invasive diagnostic approaches.
What is the impact of miRNA expression on glucose metabolism reprogramming in head and neck squamous cell carcinoma?5 answersMicroRNA (miRNA) expression has a significant impact on glucose metabolism reprogramming in head and neck squamous cell carcinoma (HNSCC). miR-9-1, which is hypermethylated in nasopharyngeal carcinoma (NPC), inhibits glycolytic metabolism by reducing lactate production, glucose uptake, and ATP generation. It directly targets hexokinase 2 (HK2), a key enzyme in glycolysis, leading to reduced HK2 protein levels. SIX1, overexpressed in HNSCC, upregulates glucose uptake and ATP production by upregulating GLUT3, a glucose transporter. miR-23a-3p targets SIX1 and suppresses glucose uptake and proliferation in HNSCC. These findings highlight the role of miRNA alterations in modulating glucose metabolism in HNSCC, providing potential therapeutic targets for this cancer type.
What is the current clinical implication of metabolism-related miRNAs in squamous cell carcinoma of the neck?5 answersMetabolism-related miRNAs in squamous cell carcinoma of the neck have important clinical implications. These miRNAs play a role in controlling proliferation, differentiation, apoptosis, metastasis, epithelial-mesenchymal transition, and immune responses in HNSCC. They are involved in metabolic reprogramming, which is necessary for tumor development and survival in an unfavorable tumor microenvironment. Additionally, miRNA-based subtypes have been identified in HNSCC, which are associated with different stages of epithelial cell differentiation and have implications for clinical outcomes. Furthermore, miRNA clusters have been found to be associated with differential mutation patterns in HNSCC, providing insights into the pathophysiology of the disease. These findings highlight the potential of metabolism-related miRNAs as biomarkers for diagnosis, prognosis, and treatment of squamous cell carcinoma of the neck.
What is the role of microRNAs in oesophageal adenocarcinoma?4 answersMicroRNAs (miRNAs) play a significant role in the pathogenesis of oesophageal adenocarcinoma (OAC). They are involved in various aspects of OAC, including carcinogenesis, progression, treatment, prognosis, and diagnosis. Dysregulated miRNAs have been found in both tissue and serum samples of OAC patients, suggesting their potential as diagnostic and prognostic biomarkers. Several miRNAs have been identified as upregulated or downregulated in OAC, and their expression profiles can discriminate between OAC and normal epithelium. Additionally, specific miRNAs have been associated with the risk of mortality after OAC diagnosis. The detection and quantification of miRNAs in OAC can be challenging due to their small size, but methods such as miRNA microarrays and quantitative real-time polymerase chain reaction (RT-qPCR) have been developed for this purpose. Overall, miRNAs have emerged as potential therapeutic targets and valuable tools for improving the diagnosis, prognosis, and prediction of therapeutic response in OAC.
How does miRNAs act on glucose metabolism in head and neck cancer?5 answersMicroRNAs (miRNAs) play a role in regulating glucose metabolism in head and neck cancer. miRNA-451 inhibits the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway, which affects glycolysis by regulating the localization of the glucose transporter 1 (GLUT1). miR-451 is negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase (AMPK), which is activated by glucose depletion-induced metabolic stress. In addition, miRNAs have been found to modulate the metabolic landscape in breast cancer, including the regulation of carbon metabolism and glycerophospholipid and N-Glycan metabolism. Although specific information on miRNA regulation of glucose metabolism in head and neck cancer is not provided in the abstracts, these findings suggest that miRNAs may play a role in modulating glucose metabolism in this type of cancer as well.
How is miRNA involved in anticancer therapy?4 answersMicroRNAs (miRNAs) play a crucial role in anticancer therapy. They can function as oncogenes or tumor suppressors, and their dysregulation is a hallmark of liver cancer. MiRNAs can be used as therapeutic targets to normalize their expression and inhibit cancer cell proliferation or increase sensitivity to chemotherapy. Small interfering RNAs (siRNAs) also have miRNA-like activity and can be used to silence disease-causing genes. The development of miRNA-based therapeutic strategies for hepatocellular carcinoma (HCC) is challenging due to the stability of the oligos and their delivery systems. Various delivery systems, including virus-based and non-viral systems, have been explored for miRNA delivery. In addition, actively targeting miRNA therapeutics to cancer cells using nano-conjugates or vesicles decorated with antibodies or ligands specific to HCC antigens or receptors can enhance efficacy and minimize damage to healthy tissue. Advances in the delivery of miRNAs have shown promise in cancer therapy. Furthermore, nano-carriers can improve the stability and delivery of miRNAs, enhancing their anticancer effects.

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