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Can breast calcifications metastasize? 

Breast cancer
Biopsy
Metastasis
Calcification
Mammography

Answers from top 10 papers

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Papers (10)Insight
Journal Article•DOI
Metastasis of lobular breast carcinoma to the cervix.
Dragan Perišić, Snežana Jančić, Dragoslav Kalinović, Milica Čekerevac 
01 Aug 2007-Journal of Obstetrics and Gynaecology Research
19 Citations
In conclusion, as breast carcinoma can metastasize to atypical places (cervix, endometrium, etc.
Open access•Journal Article
Loss of Heterozygosity Events Impeding Breast Cancer Metastasis Contain the MTA1 Gene
Michelle D. Martin, Kathy Fischbach, C. Kent Osborne, Syed K. Mohsin, D. Craig Allred, Peter O'Connell 
01 May 2001-Cancer Research
33 Citations
Thus, if primary breast cancers delete this region, their ability to metastasize decreases.
Open access•Journal Article•DOI
The relationship between tumour size, nodal status and distant metastases: on the origins of breast cancer
Victoria Sopik, Victoria Sopik, Steven A. Narod, Steven A. Narod 
24 Apr 2018-Breast Cancer Research and Treatment
100 Citations
This calls into question the conventional model that the capacity for a primary breast tumour to metastasize increases as the tumour enlarges.
Open access•Journal Article•DOI
Patterns of mammographically detected calcifications after breast-conserving therapy associated with tumor recurrence
D. David Dershaw, Catherine S. Giess, Beryl McCormick, Patrick Borgen, Laura Liberman, Andrea F. Abramson, Elizabeth Morris 
01 Apr 1997-Cancer
17 Citations
Some authors have suggested that mammographically evident calcifications that would be considered benign in other situations can be due to carcinoma in women who have undergone breast conservation.
Open access•Journal Article•DOI
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
Robert A H Scott, Nicholas Stone, Catherine Kendall, Kalotina Geraki, Keith Rogers 
14 Sep 2016
46 Citations
When combined with other recent evidence on the effect of magnesium on hydroxyapatite precipitation, this suggests a mechanism explaining observations that carbonate levels within breast calcifications are lower in malignant specimens.
Journal Article•DOI
Intermediate to highly suspicious calcification in breast lesions: a radio-pathologic correlation
Gary Tse, Puay Hoon Tan, Humairah S. Cheung, Winnie C.W. Chu, Wynnie W.M. Lam 
01 Jul 2008-Breast Cancer Research and Treatment
54 Citations
Pathologically, calcifications in breast lesions are of dystrophic type, and may occur in either the secretory materials or necrotic debris, with inflammation and osteopontin being plausible mediators.
Journal Article•DOI
Calcifications Associated with Lactational Changes of the Breast: Mammographic Findings with Histologic Correlation
Cecilia L. Mercado, Tova Koenigsberg, Diane Hamele-Bena, Suzanne J. Smith 
01 Sep 2002-American Journal of Roentgenology
17 Citations
Calcifications associated with lactational changes of the breast may have a suspicious appearance on mammography.
Journal Article•DOI
Unusual cases of metastases to the breast. A report of 17 cases diagnosed by fine needle aspiration.
Odile David, Paolo Gattuso, Wafai Razan, Krzysztof Moroz, Nina Dhurandhar 
01 Mar 2002-Acta Cytologica
38 Citations
Virtually any malignancy may metastasize to the breast.
Journal Article•DOI
Multifocal and Multicentric Breast Cancer: Does Each Focus Matter?
Nathan J. Coombs, John Boyages 
20 Oct 2005-Journal of Clinical Oncology
176 Citations
The tendency of breast tumors to metastasize is a reflection of the total tumor load.
Journal Article•DOI
Metastases to and from the Breast.
Alessandro Bombonati, Melinda F. Lerwill 
01 Sep 2012-Surgical Pathology Clinics
14 Citations
Nonmammary tumors can also metastasize to the breast, although this is a rare phenomenon.

Related Questions

What are the mechanisms by which tumors metastasize?5 answersTumors metastasize through a series of steps involving interactions with the microenvironment, mechanical properties, and molecular changes. Cancer cells interact with the endothelial cells and secrete hydrolytic enzymes to degrade the matrix, allowing them to invade blood and lymphatic vessels. The tumor microenvironment plays a crucial role in tumor spread, with tumors secreting growth factors and forming prior niches to guide their spread. Reorganization of the cytoskeleton and extracellular matrix is important for tumor cell migration and invasion. Metastasis involves dynamic molecular changes, including genetic and epigenetic alterations, leading to disintegration of cellular junctions and epithelial to mesenchymal transition. The process of metastasis is complex and involves various mechanisms such as epithelial-mesenchymal transition, cancer stem cells, extracellular vesicles, and pre-metastatic niche formation. Understanding these mechanisms is crucial for developing effective therapeutic approaches against metastatic cancer.
Does hypocalcemia occurs in situations of metastasis calcification?2 answersHypocalcemia can occur in situations of metastasis calcification. It is a relatively uncommon paraneoplastic syndrome associated with cancer. In some cases, hypocalcemia can be caused by excessive calcium consumption by the tumor itself. Additionally, hypocalcemia can be induced by antiresorptive therapy (ArT) used to treat bone metastasis in cancer patients. Severe hypocalcemia has been observed in patients treated with denosumab, a RANKL inhibitor, compared to zoledronic acid, a bisphosphonate. However, the incidence and severity of hypocalcemia may vary depending on the specific treatment and patient population. Overall, hypocalcemia should be considered and evaluated in patients with cancer, especially when neurological symptoms are present or when undergoing certain treatments for bone metastasis.
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