Can cd8 T cells induce apoptosis?
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33 Citations | In HNL, then, CD8-positive cytotoxic T-cells are likely to undergo apoptosis. |
29 Citations | Despite differentiation into effectors, the late-primed CD8 T cells lacked full cell division, displayed increased apoptosis, and failed to develop into memory cells, suggesting that the extent of stimulation influences the survival of effector CD8 T cells. |
148 Citations | These results suggest that CD8(+)CD28(-) T cells are more functionally differentiated than the CD8(+)CD28(+) subset and indicate they may represent a terminally differentiated effector population which is destined for clearance by apoptosis at the end of the immune response. |
Open access•Journal Article | Significantly greater proportions of CD8(+) T cells than CD4(+) T cells were apoptotic (P < 0.0002), which indicates that CD8(+) T cells were especially sensitive to apoptosis. |
18 Citations | We show that both TEM and TEMRA CD8+ T cells are resistant to apoptosis, whereas TN and TCM CD8+ T cells are sensitive to apoptosis. |
| Cells from the memory subsets of CD8+ T cells showed a high incidence of spontaneous death in unstimulated cultures, indicating that these cells have received signals for death by apoptosis in vivo. | |
27 Citations | Our data show that naïve and TCM CD8+ T cells were sensitive, whereas TEM and TEMRA CD8+ T cells were relatively resistant to TNF-a-induced apoptosis. |
23 Citations | A portion of CD8 T cells undergoes apoptosis upon CD3/CD28 activation in a manner that is partially prevented by the clinically used anti-TNF agents infliximab and etanercept. |
40 Citations | These results show that CTX-III selectively enhanced activation-induced apoptosis in CD8(+) T cells. |
| These findings indicate that PD-L1 induces apoptosis in activated CD8+ T cells in part by signaling through CD80. |
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