Can dengue cause giant platelets?
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140 Citations | Nevertheless, hemorrhage in dengue without circulatory collapse is most likely due to activation of platelets rather than coagulopathy, which is well compensated. |
19 Citations | Mean platelet volume is not important as prognostic parameter in dengue fever. |
53 Citations | Clinical manifestations of thrombocytopenia are not related only to the number of peripheral platelets in dengue infection, but its recovery is associated with clinical improvement. |
17 Citations | Thrombocytopenia may not always be a feature of dengue. |
Related Questions
Why dengue causes low platelet causes?5 answersDengue causes low platelet counts due to various mechanisms. One mechanism is the direct infection of platelets by the dengue virus, leading to their clearance from the bloodstream. Another mechanism is the adhesion of platelets to leukocytes and vascular endothelium, which can result in their consumption. Additionally, platelet clearance can be mediated by anti-platelet antibodies. The infection of hematopoietic progenitors and stromal cells, including megakaryocytes, in the bone marrow can also contribute to decreased platelet production. Thrombocytopenia in dengue is associated with platelet dysfunction and altered functionality, as well as their role in the immune response to the virus. The activation and depletion of platelets in dengue infections are correlated, with elevated platelet activation observed during the acute phase of the disease. Overall, dengue-induced thrombocytopenia is a complex process involving multiple mechanisms that affect platelet number and function.
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