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Can food components influence apoptosis? 

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This study demonstrates that food restriction preferentially enhances apoptosis of preneoplastic cells.
Food bioactive components that affect various aspects of metabolism may be important tools to reverse glycolytic to oxidative metabolism and enhance sensitivity to apoptosis.
For example, in some cell types NO can promote apoptosis, whereas in other cells NO inhibits apoptosis.
Open accessJournal ArticleDOI
Fiona Armstrong, John C. Mathers 
01 May 2000
12 Citations
Effective chemopreventative agents will include dietary components that enhance the immune system’s ability to identify transformed cells and to target them for apoptosis.
The ability of membrane-active agents to block apoptosis suggests that membranes or their lipid components play prominent roles in injury-induced apoptosis.
We conclude that the essential oil contains components that are effective at inducing apoptosis.
The results suggest that yogurt would influence the balance between mitosis and apoptosis, which was modified during the carcinogenesis process, by increasing cellular apoptosis.
Diet components may also modify the risk of cancer through the influence on multiple processes, including DNA repair, cell proliferation and apoptosis.
Furthermore, DNA-repair proteins can regulate apoptosis.
Solvent extracts of human and mouse food were also able to block pitavastatin-induced apoptosis, suggesting diet might influence the outcome of clinical trials.

Related Questions

Which natural methods have been shown to be most effective in apoptosis of tumors?4 answersNatural compounds that have been shown to be effective in inducing apoptosis in tumors include phenols such as tannins, caffeic acid, capsaicin, gallic acid, resveratrol, and curcumin. Other natural compounds with apoptotic-inducing properties include extracts and fractions from plants and marine species, such as Taxol from Taxus brevifolia and marine sponges. Additionally, selected natural chemopreventive agents like vitamin E, curcumin, EGCG, quercetin, resveratrol, and genistein have been found to induce apoptosis in cancer cells. Herbal medicines have also been studied for their anti-pancreatic cancer effects, with active ingredients triggering apoptosis through various pathways, including death receptors, mitochondrial-dependent pathways, NF-κB mediated pathways, MAPK mediated pathways, ERS mediated pathways, PI3K-Akt mediated pathways, and other pathways. Furthermore, natural plant products have shown promise in inducing apoptosis in cancer stem cells, providing new ideas for developing anti-cancer drugs.
What food has beneficial effect on telomeras?5 answersA higher consumption of omega-3 fatty acids, fish, nuts and seeds, fruits and vegetables, green leafy and cruciferous vegetables, olives, legumes, polyunsaturated fatty acids, and an antioxidant-rich diet has been associated with a beneficial effect on telomere length. Additionally, green tea consumption has been suggested to counteract telomere attrition and protect against oxidative damage. Furthermore, dietary supplementation with a mix of S-adenosyl-methionine (SAMe) and a polysaccharide extract of Astragalus (APS) has been shown to increase telomere length in circulating lymphocytes. Finally, n-3 polyunsaturated fatty acids (PUFAs) have been linked to telomere length and have been associated with ameliorating telomere attrition through anti-oxidation and anti-inflammation mechanisms.
What is the relationship between food and colon cancer?5 answersFood plays a critical role in the risk of colon cancer. Several studies have shown that certain foods and dietary patterns can either increase or decrease the risk of colon cancer. Plant-based foods like fruits, cereals, and legumes have been found to inhibit colon carcinogenesis due to their fiber, protein, and various secondary metabolites. On the other hand, the availability of specific foods such as red meat, animal fats, and alcoholic beverages has been associated with an increased risk of colon cancer incidence and mortality. Additionally, dietary natural products like berries, cruciferous vegetables, garlic, and soy have shown potential in preventing and managing colon cancer through various mechanisms such as inhibiting tumor growth and inducing apoptosis. Furthermore, the composition of the gut microbiota, which is influenced by diet, has been linked to the risk of colon cancer. Overall, a healthy diet rich in plant-based foods and low in unhealthy foods can help reduce the risk of colon cancer.
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