Search or ask a question

Can I take pregnenolone with thyroid medication?

Cholesterol side-chain cleavage enzyme

Dehydroepiandrosterone

Pregnenolone sulfate

Steroid biosynthesis

Answers from top 1 papers

PDF

Open Access

More filters

Papers (1)	Insight
Journal Article•DOI Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain Kazuyoshi Tsutsui, Takeshi Yamazaki - Show less +1 more 24 Apr 1995-Brain Research 143 Citations	Most accumulation of pregnenolone in the brain may be independent of the peripheral endocrine gland system.

My columns

Related Questions

What is pregnenolone?4 answersPregnenolone is an endogenous steroid that is produced in the brain and is involved in various brain functions. It is the first steroid to be synthesized from cholesterol and can be further metabolized into other steroids. Pregnenolone has been recognized as a biomarker for brain-related disorders and has been found to have specific targets, including the type-1 cannabinoid receptor (CB1R). It has been shown to promote microtubule polymerization, which is important for neural development and function. Pregnenolone and its derivatives have potential therapeutic applications in neurodevelopmental diseases, mood disorders, and conditions associated with microtubule defects. The quality assessment of pregnenolone drug products is important due to the lack of standardization in compounded hormone therapies. Overall, pregnenolone plays a crucial role in brain function and has potential therapeutic implications for various neurological disorders.

Can the use of birth control pill have an impact on the thyroid?5 answersThe use of birth control pills can have an impact on thyroid function. Studies have shown that a longer history of using birth control pills is strongly associated with hypothyroidism, especially for more than 10 years. Oral contraceptives (OCs) can interact with the hepatic production of thyroid-binding globulin (TBG) and affect serum levels of thyroxine (T4) and triiodothyronine (T3). OCs containing estrogen can increase liver proteins such as TBG, while progestogens modulate estrogen-dependent effects. However, there is limited data on the effects of OCs on thyroid function tests, leading to potential misdiagnosis and mistreatment. Additionally, hormonal treatment with OCs can increase thyroid hormones, including thyroxine-binding globulin and reverse triiodothyronine. Although OCs may alter some thyroid function tests, the impact on thyroid function is generally minimal.

Can I take allergy meds with my thyroid meds?5 answers

Can prednisone help thyroid nodules?6 answers

Can you take Midol with thyroid medication?6 answers

Does thyroid medication have steroids in it?8 answers

See what other people are reading

How acetate are used in milk fat synthesis?

Acetate plays a crucial role in milk fat synthesis by promoting de novo fatty acid production in mammary epithelial cells. Studies have shown that acetate enhances the expression of lipogenic genes and triglyceride production by activating the mTOR signaling pathway in bovine and mouse mammary epithelial cells. Acetate, along with β-hydroxybutyrate, is a major substrate for de novo fatty acid synthesis in dairy cows, leading to increased milk fat yield and concentration when supplied in higher amounts. Acetate's effects on milk fat synthesis involve the activation of key pathways such as GPCR, mTORC1, and SREBP1, ultimately promoting lipid biosynthesis and fat accumulation in the mammary glands of mammals. Therefore, acetate serves as a critical precursor for fatty acid synthesis, contributing significantly to the production of milk fat in lactating animals.What is the ontogeny of fetal testosterone in male mice?

The ontogeny of fetal testosterone in male mice involves a dynamic pattern of expression. Testosterone levels in male mice are initially high at birth, decrease in the early days of life, and remain low until around day 20. Subsequently, there is a rapid increase in testosterone levels between days 20 and 40, reaching peak levels, followed by a transient decrease after day 40. This surge in testosterone coincides with the pre-pubertal increase in testosterone levels, correlating with the development of male characteristics such as body weight differences and seminal vesicle growth. Additionally, exposure to neonatal testosterone can have long-term effects on male mice, leading to disruptions in reproduction, energy homeostasis, and predisposition to hypogonadism and obesity in adulthood.Why is Selenium good for sexual health and testosterone production?

Selenium plays a crucial role in sexual health and testosterone production due to its antioxidant properties and involvement in various biological processes. Studies have shown that selenium can protect Leydig cells from oxidative damage induced by nickel, thereby promoting testosterone synthesis. Additionally, selenium supplementation has been found to counteract the detrimental effects of electromagnetic radiation on the male reproductive system, leading to improved sperm parameters and hormone levels. Furthermore, selenium's impact on gut microbiota and selenoproteins in testicular tissue highlights its significance in male reproductive health. Selenium's functions are mediated through specific selenoproteins like glutathione peroxidase and selenoprotein P, which are essential for antioxidant defense, hormone regulation, and sperm integrity. Overall, selenium's ability to enhance antioxidant defenses, regulate hormone levels, and support reproductive processes underscores its importance for sexual health and testosterone production.How does finasteride affect hormones?

Finasteride, a 5α-reductase inhibitor, impacts hormone levels in various ways. Studies show that prolonged use of finasteride in women leads to decreased dihydrotestosterone (DHT), estradiol, progesterone, and androstenedione levels, while increasing testosterone levels, affecting gene expression, inducing DNA damage, and causing heavy menstrual bleeding. In men with premature androgenetic alopecia, low-dose finasteride treatment reduces 5α-reduced steroids, potentially contributing to depression. Additionally, finasteride therapy in men with benign prostate hyperplasia results in decreased inhibitory steroids and increased neuroactive steroids, possibly leading to depressive symptoms. Furthermore, in animal studies, finasteride treatment causes hormonal imbalances, with decreased testosterone and increased estradiol levels, leading to glandular regression and stromal remodeling in the prostate. Overall, finasteride alters hormone profiles, potentially impacting various physiological and psychological aspects.How has the use of ginseng in testosterone research evolved over the past five years?

In recent years, ginseng has played a significant role in testosterone research, showcasing various beneficial effects. Studies have demonstrated that ginseng, particularly Korean red ginseng, can potentiate the inhibitory effects of testosterone on obesity and adipogenesis. Ginsenosides, the main active components of ginseng, have been shown to be functional ligands of the glucocorticoid receptor (GR), influencing steroidogenesis. Moreover, Korean ginseng berry extract (GBE) has been found to induce steroidogenic effects by increasing testosterone production both in vitro and in vivo, making it a promising therapeutic agent for improving men's health. Additionally, ginseng has been linked to inhibiting ornithine decarboxylase activity, 5-alpha reductase, and prolactin secretion, suggesting its potential as a novel addition to hirsutism treatment.What are the specific effects of ginseng on testosterone levels in humans according to recent PubMed articles?

Recent PubMed articles have highlighted the effects of ginseng on testosterone levels in humans. One studydemonstrated that ginseng intake significantly increased salivary testosterone levels in younger women, with a more modest effect in older women. Additionally, ginseng has been associated with inhibiting ornithine decarboxylase activity, 5-alpha reductase, and prolactin secretion, which could potentially impact testosterone levels. Moreover, ginseng has been traditionally used to enhance sexual behavior and treat sexual dysfunction, with positive effects on libido and copulatory performances in both animal and human studies. These findings collectively suggest that ginseng may play a role in modulating testosterone levels and improving male reproductive function.How is testosterone synthesised from cholesterol?

Testosterone is synthesized from cholesterol through a series of enzymatic reactions. Cholesterol is first converted to pregnenolone by the cytochrome P450 side-chain cleavage enzyme in all steroidogenic tissues. In Leydig cells of the testis, pregnenolone is further metabolized into testosterone by enzymes like 3β-HSD, CYP17A1, and 17β-HSD3 in the endoplasmic reticulum. Additionally, testosterone can be converted to the more potent androgen dihydrotestosterone (DHT) by the enzyme 5α-reductase. The process involves multiple steps and enzymes, with cholesterol serving as the essential precursor for all steroid hormones, including testosterone. Microbial metabolism of cholesterol followed by chemical reduction has also been utilized to prepare testosterone, showcasing alternative methods for its synthesis.How does chronic stress affect cyp11a1 expression?

Chronic stress can impact CYP11A1 expression differently based on the specific stress model. In the context of the chronic mild stress (CMS) model of depression, it was observed that CMS moderately affects CYP expression, including CYP2B, CYP2C11, and CYP3A, with varying effects compared to other stress types. On the other hand, exposure to psycho-emotional stress (PES) led to a significant decrease in CYP2E1 expression in the liver of mice, attributed to intensified peroxide processes and oxidative stress. These findings highlight the complex relationship between chronic stress and CYP expression, indicating that different stressors can lead to distinct alterations in cytochrome P450 enzyme levels, potentially influencing steroid metabolism and physiological functions.Does pregnelone sulphate create a response in mice in the eye wipe test?

Pregnenolone sulfate (PS) has been shown to induce responses in mice in various behavioral tests. PS positively modulates NMDA receptors, impacting learning, memory, and social behaviors. In the eye wipe test, which is not explicitly mentioned in the provided contexts, PS's effects were not directly assessed. However, studies have demonstrated that PS can normalize hyperlocomotion, stereotypic behavior, and cognitive deficits in mice, indicating its potential to modulate various behaviors. PS also interacts with NMDA receptors, affecting memory performance and cognitive functions. The specificity of responses to sulfated steroids in the vomeronasal organ of female mice suggests a targeted action of these compounds. While the direct impact of PS on the eye wipe test in mice is not outlined, its broader effects on behavior and cognitive functions indicate its potential influence on various sensory and motor responses.Does masturbating decrease testesterone levels?

Masturbation does not decrease testosterone levels; in fact, it leads to an increase in various steroid levels, including pregnenolone and dehydroepiandrosterone (DHA). Additionally, a study on young European men found that serum testosterone levels were not associated with sperm parameters, indicating no direct impact of testosterone on semen quality. However, in patients with erectile dysfunction, hypotestosteronemia was linked to impaired bioactivity of luteinizing hormone (LH), suggesting that reduced testosterone levels in such cases are due to LH hypoactivity, which is reversible upon resumption of sexual activity. Therefore, there is no direct evidence to support the claim that masturbating decreases testosterone levels based on the available research data.How to naturally increase testosterone?

To naturally increase testosterone levels, one can consider utilizing herbal compositions like those derived from Punica granatum and Theobroma cacao, which have shown potential in enhancing anabolic and androgenic activities in the body. Additionally, Korean ginseng berry extract (GBE) has been found to promote steroidogenesis, leading to increased testosterone production both in vitro and in vivo, making it a promising natural agent for improving men's health. Another method involves preparing a natural pack containing various plant extracts like Glycine max, Phaseolus radiatus, and Castanea crenata, which may have skin whitening and moisturizing effects. These natural approaches offer alternatives to testosterone hormonal replacement therapy, providing potential benefits for individuals looking to naturally enhance their testosterone levels.