Can insulin injecting women can give rise to birth?
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| These results suggest that the genotype Gly972Arg may influence birth weight, reinforcing the hypothesis that genetically determined insulin resistance and/or reduced insulin secretion can result in impaired insulin-mediated growth in the fetus. | |
| —Obese mothers can give birth to normal birth weight babies who later develop obesity and insulin resistance. | |
| This suggests that prenatal restraint impairs insulin secretion, but increases insulin sensitivity, before birth. | |
| Key messages Infants of women with established insulin dependent diabetes mellitus have 10 times the population risk of congenital malformations and five times the stillbirth rate Excess mortality among infants of women with pre-existent insulin dependent diabetes mellitus is predominantly due to congenital malformations The birth prevalence of congenital malformations can be reduced by good periconceptional glycaemic control, but the challenge remains to implement this on a population basis Macrosomia remains a problem among infants of women with established insulin dependent diabetes mellitus | |
82 Citations | In contrast to healthy pregnant women, insulin secretion in women with GDM is defective and, therefore, is unable to rise adequately to compensate for the insulin resistance; the result is hyperglycemia. |
28 Citations | Diabetic women are more likely to give birth to infants with congenital malformations than are nondiabetic women. |
14 Citations | Women with type I, insulin-dependent diabetes can now have the same chances as women without diabetes to have a healthy infant. |
6 Citations | Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them. |
| Together, these results demonstrate that progenitors that have the potential to give rise to insulin-expressing cells can be derived from murine embryonic stem cells. | |
87 Citations | It can be also applied to pregnant women with latent diabetes, in whom insulin therapy can reduce fetal risk. |
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