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Can Neuralink help with Parkinson's disease? 

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It is suggested that aggravation of Parkinson's disease mainly results from increasing severity of cerebral nondopaminergic lesions.
Journal ArticleDOI
Niall Quinn, Peter Critchley, C. D. Marsden 
01 Jan 1987-Movement Disorders
440 Citations
These patients with young onset Parkinson's disease responded well to levodopa therapy.
The clinical data suggest that levodopa either slows the progression of Parkinson's disease or has a prolonged effect on the symptoms of the disease.
The present study provides additional evidence for involvement of the cerebral cortex in Parkinson's disease.
Clinical studies suggest that these findings may have important implications for the treatment of Parkinson's disease.

Related Questions

How biomechatronics help in rehabilitation of Parkinson's patient?5 answersBiomechatronics, specifically the use of audio-biofeedback technology devices, such as Electroskip, have shown promise in the rehabilitation of Parkinson's patients. A case study by Szydlowski et al. demonstrated that a rehabilitation program focused on functional tasks, balance, and gait training using Electroskip technology resulted in clinically significant improvements in gait and balance. Additionally, Abd Rauf et al. highlighted the need for more creative approaches to assist in the rehabilitation process for Parkinson's patients, and suggested that exergames designed specifically for this population could be beneficial. Furthermore, Bacanoiu et al. conducted a systematic review and found that physical exercises, including those performed with physical devices, have the capacity to improve motor and cognitive functions in Parkinson's patients. These findings suggest that biomechatronics, such as audio-biofeedback technology and exergames, can play a role in the rehabilitation of Parkinson's patients by improving gait, balance, and overall motor and cognitive functions.
Is Nurr1 effective in LRRK2 Parkinson’s disease?5 answersNurr1 has been shown to have a role in the generation and maintenance of dopaminergic neurons and has anti-inflammatory effects in Parkinson's disease (PD) models. It directly binds to the RasGRP1 gene to regulate its expression and is involved in the Ras-Raf-MEK-ERK signaling cascade in inflammation signaling. Nurr1 also promotes the differentiation of neural stem cells (NSCs) into dopaminergic neurons and protects dopaminergic neurons from neuroinflammation insults. However, there is no specific mention of Nurr1's effectiveness in LRRK2 Parkinson's disease in the provided abstracts.
How do stem cell therapies work for treating Parkinson's disease?5 answersStem cell therapies for treating Parkinson's disease involve the transplantation of stem cells into the brain to replace the lost dopamine-producing neurons in the substantia nigra. These therapies have shown potential in improving motor functions in PD patients. The stem cells can be derived from various sources such as mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). The transplanted cells interact with the inflammatory microenvironment in the brain, leading to the improvement of dopaminergic neuron loss. Exosomes derived from mesenchymal stem cells have also been found to have therapeutic potential in PD treatment, promoting neuroprotection and crossing the blood-brain barrier. However, there are challenges and shortcomings in stem cell therapy, including the need to produce a sufficient number of authentic substantia nigra dopamine neurons, ensuring integration into the host brain, and preventing tumor formation. Further research is needed to address these issues and optimize stem cell-based therapies for Parkinson's disease.
What neurofeedback protocols help manage Parkinson's disease?5 answersNeurofeedback protocols that have been explored for managing Parkinson's disease include real-time processing of pathological subthalamic beta oscillations through deep brain electrical neurofeedback. This involves providing visual neurofeedback based on the patient's volitional control of ongoing beta-oscillatory activity measured through implanted deep brain stimulation (DBS) electrodes. During training sessions, patients were able to gradually reduce beta-oscillatory activity and improve motor performance. The acquired strategies for controlling deep brain activity through neurofeedback were retained in the short-term, even after removing visual neurofeedback. These findings suggest that neurofeedback-based strategies optimized through real-time visual feedback of pathological oscillations may provide therapeutic benefits for Parkinson's patients in improving symptom control.
What are the potential benefits of NAD supplementation for people with Parkinson's disease?4 answersNAD supplementation has potential benefits for people with Parkinson's disease. It may positively affect disease onset and progression, supporting reductions in neuroinflammation and neurodegeneration. NADH, a form of NAD, has been used in an open-label trial and showed a beneficial clinical effect in patients with Parkinson's disease, improving disability and increasing the daily "on phases". However, recommendations for using NADH in Parkinson's disease are premature, as further research is needed. While there have been limited clinical trials, NAD upregulation as a therapeutic strategy has shown promising results in the treatment of psoriasis and enhancement of skeletal muscle activity. Further trials are required to determine the optimal method of raising NAD levels and to compare the benefits of NAD supplementation to other interventions such as exercise programs and dietary interventions tailored to older individuals.
How can regenerative medicine be used to treat Parkinson's disease?5 answersRegenerative medicine offers potential treatments for Parkinson's disease by replacing lost neurons and restoring normal movement. Cell and gene therapies have advanced from research tools to clinical-grade products for patients, constituting a significant portion of Phase I clinical trials for Parkinson's disease. Mesenchymal stem cells (MSCs) show promise in providing benefit through their neurotrophic, anti-inflammatory, and anti-apoptotic effects. Potential regenerative treatments, including stem-cell-based treatments and viral gene delivery, are being developed and clinical trials are on the horizon. Evidence from preclinical studies suggests that stem cell lines may be translated into viable cellular therapies for Parkinson's disease. To evaluate the efficacy of cellular therapies, a comprehensive assessment protocol with co-primary and composite outcome measures is proposed.

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