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Can porphyromonas gingivalis travel in blood stream to distant organs]? 

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Porphyromonas gingivalis, an oral pathogen associated with periodontitis, has the ability to travel in the bloodstream to distant organs. Several mechanisms have been proposed for the translocation of P. gingivalis. Firstly, proteolytic enzymes secreted by P. gingivalis can degrade adhesion molecules and weaken the structural integrity of the oral mucosa, allowing the bacteria to penetrate the tissue . Secondly, P. gingivalis can actively enter tissue cells and transfer to the next layer or the extracellular space, a process known as transcytosis . Thirdly, professional phagocytes can take up P. gingivalis and release it into the bloodstream . Lastly, P. gingivalis can adhere to hyphae forming Candida albicans, which can penetrate the mucosal tissue and allow P. gingivalis to reach deeper structures . These mechanisms enable P. gingivalis to disseminate from the oral cavity to distant organs through the bloodstream, potentially contributing to the development of systemic diseases .

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Yes, according to the paper, Porphyromonas gingivalis can enter the blood and disseminate to distant organs through the bloodstream.
Yes, Porphyromonas gingivalis can disseminate to remote sites through the bloodstream, as shown in the study.
The paper states that Porphyromonas gingivalis can travel to the bloodstream through professional phagocytes, but it does not mention if it can reach distant organs.
The paper states that Porphyromonas gingivalis can invade local tissues through the blood circulation, suggesting that it can travel in the bloodstream to distant organs.

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