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Can sex increase platelets?

Adenosine diphosphate

Fibrinogen receptor

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Open access•Journal Article•DOI Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy. Julia R. Coleman, Ernest E. Moore, Marguerite R. Kelher, Jason M. Samuels, Mitchell J. Cohen, Angela Sauaia, Anirban Banerjee, Christopher C. Silliman, Erik D. Peltz - Show less +8 more 01 Nov 2019-Journal of Trauma-injury Infection and Critical Care 23 Citations	Male and female platelets have differential response to stimuli, suggesting sex-dependent signaling and cellular activation.
Journal Article•DOI The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. Michael R. Buchanan, Janice Rischke, R Butt, Alexander G.G. Turpie, Jack Hirsh, Jack Rosenfeld - Show less +5 more 15 Jan 1983-Thrombosis Research 45 Citations	It is unclear whether this effect is due to sex-related differences in the effect of aspirin on platelets, the vessel wall, or the pharmacokinetics of aspirin.
Journal Article•DOI Platelets: testing, dosing and the storage lesion--recent advances. Richard M. Kaufman 01 Jan 2006-Hematology 44 Citations	Finally, new approaches to dosing platelets may help extend the limited supply.
Journal Article•DOI Direct Measurement of Nitric Oxide Production in Platelets: Relationship with Cytosolic Ca2+ Concentration Frédérique Lantoine, Annie Brunet, Fethi Bedioui, Jacques Devynck, Marie-Aude Devynck - Show less +4 more 24 Oct 1995-Biochemical and Biophysical Research Communications 73 Citations	These results confirm that human platelets can generate NO.
Open access•Journal Article•DOI Platelets of Female Mice Are Intrinsically More Sensitive to Agonists Than Are Platelets of Males Xing-Hong Leng, Song Yun Hong, Susana Larrucea, Wei Zhang, Tong Tong Li, José A. López, Paul F. Bray - Show less +6 more 01 Feb 2004-Arteriosclerosis, Thrombosis, and Vascular Biology 72 Citations	The sex differences we observed were intrinsic to platelets, because they were observed in washed platelets, but not when platelets were in plasma.

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