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Can Unmyelinated neurons regenerate?

Regeneration (biology)

Cutaneous nerve

Unmyelinated nerve fiber

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Journal Article•DOI Reactions of unmyelinated nerve fibers to injury. An ultrastructural study. Garth M. Bray, Jean-Marie Peyronnard, Albert J. Aguayo - Show less +2 more 20 Jul 1972-Brain Research 70 Citations	Thus the capacity of unmyelinated nerve fibers for rapid regeneration has been demonstrated.
Journal Article•DOI Cutaneous nerve regeneration in the rat: reinnervation of the denervated skin by regenerative but not by collateral sprouting Gábor Jancsó, Elizabeth Király - Show less +1 more 11 Apr 1983-Neuroscience Letters 29 Citations	It is concluded that these particular unmyelinated sensory nerves regenerate by means of regenerative sprouting but apparently lack the ability for collateral sprouting.
Journal Article•DOI Schwann cell internuclear distances in normal and regenerating unmyelinated nerve fibers. Jean-Marie Peyronnard, Albert J. Aguayo, Garth M. Bray - Show less +2 more 01 Jul 1973-JAMA Neurology 28 Citations	This suggests that in regenerating unmyelinated nerve fiber bundles, as in regenerating myelinated fibers, Schwann cell territories are shorter than normal.
Journal Article•DOI The numbers of unmyelinated and myelinated axons in normal and regenerated rat saphenous nerves Deborah A. Carter, S.J.W. Lisney - Show less +1 more 01 Sep 1987-Journal of the Neurological Sciences 46 Citations	These changes associated with unmyelinated axons in regenerated nerves are likely to contribute to the sensory, vasomotor and sudomotor abnormalities that sometimes occur after peripheral nerve injury and regeneration.

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Are there unmyelinated axons?3 answersUnmyelinated axons are present in the nervous system and have been largely ignored in previous studies. Most modeling efforts have focused on myelinated axons, but peripheral nerves are primarily composed of unmyelinated axons. These unmyelinated fibers can be resolved using stain-free widefield fluorescence imaging. A three-dimensional model for myelinated neurons includes Hodgkin-Huxley equations to represent membrane dynamics at unmyelinated areas. The characteristics of axons, including transmission loss and velocity, differ between myelinated and unmyelinated axons. In summary, unmyelinated axons are a prevalent type of fiber in the nervous system and have important implications for understanding connectomes and designing therapies.

Can orexin neurons regrow?5 answersOrexin neurons can be lost due to various factors such as endoplasmic reticulum stress, excitotoxic insults, and neurodegeneration caused by diphtheria toxin A. However, there is limited evidence regarding the regrowth of orexin neurons. In a study by Katsuki and Akaike, it was found that orexin neurons were selectively eliminated in response to excitotoxic insults, suggesting that the loss of orexin neurons in narcolepsy may be irreversible. Another study by Tabuchi et al.showed rapid neurodegeneration of orexin neurons in a mouse model, resulting in disrupted sleep architecture and cataplexy. While temporary doxycycline removal enabled partial lesion of orexin neurons, the regrowth of these neurons was not specifically addressed. Therefore, based on the available evidence, it is unclear whether orexin neurons have the ability to regrow. Further research is needed to investigate the regenerative potential of orexin neurons.

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