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Can you have LH surge without estrogen? 

Ovariectomized rat
Hypothalamus
Estrogen
Luteinizing hormone
Gonadotropin

Answers from top 10 papers

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Papers (10)Insight
Open access•Journal Article•DOI
Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing hormone secretion in normal women: influence of physiological variations in periovulatory ovarian steroid hormone secretion.
Marc A. Fritz, Robert I. Mclachlan, Nancy L. Cohen, Kristine D. Dahl, William J. Bremner, Michael R. Soules 
01 Aug 1992-The Journal of Clinical Endocrinology and Metabolism
34 Citations
These data suggest that in women, 1) onset of the midcycle surge in LH-RIA and LH-BIO is simultaneous, and 2) surge characteristics are not influenced by physiological variations in steroid hormone secretion that occur beyond the thresholds required for surge initiation.
Open access•Journal Article•DOI
Compensation by pulsatile GnRH infusions for incompetence for oestradiol-induced LH surges in long-term ovariectomized gilts and castrated male pigs.
F. Stickan, N. Parvizi, F. Elsaesser 
01 Mar 1999-Reproduction
11 Citations
These results support the hypothesis that oestradiol must inhibit secretion of LH before an LH surge can occur.
Journal Article•DOI
Midcycle levels of sex steroids are sufficient to recreate the follicle-stimulating hormone but not the luteinizing hormone midcycle surge: evidence for the contribution of other ovarian factors to the surge in normal women.
Ann E. Taylor, H A Whitney, Janet E. Hall, Kathryn A. Martin, William F. Crowley 
01 May 1995-The Journal of Clinical Endocrinology and Metabolism
46 Citations
In conclusion, sex steroids alone do not seem to be sufficient to stimulate the normal midcycle LH surge.
Journal Article•DOI
Induced LH surges in the rhesus monkey: Strength-duration characteristics of the estrogen stimulus
F. J. Karsch, R. F. Weick, W.R. Butler, D. J. Dierschke, L. C. Krey, G. Weiss, J. Hotchkiss, T. Yamaji, Ernst Knobil 
01 Jun 1973-Endocrinology
183 Citations
In all instances, LH surges were initiated before the capsules were removed, showing that this response is not a consequence of estrogen withdrawal.
Open access•Journal Article•DOI
Induction of the Luteinizing Hormone Surge by Intrahypothalamic Application of Estrogen in the Rhesus Monkey
Richard F. Weick
01 Mar 1981-Biology of Reproduction
11 Citations
Thus it seems unlikely that estrogen induces the LH surge in the rhesus monkey by an action in the rostral hypothalamus.
Journal Article•DOI
The oestrogen-induced surge of LH requires a 'signal' pattern of gonadotrophin-releasing hormone input to the pituitary gland in the ewe.
Iain J. Clarke, J. T. Cummins, M. Jenkin, David James Phillips 
01 Jul 1989-Journal of Endocrinology
44 Citations
These results suggest that the oestrogen-induced LH surge is initiated by a 'signal' pattern of GnRH secretion from the hypothalamus.
Journal Article•DOI
Plasma immunoreactive estrogens and LH during the menstrual cycle.
Guy E. Abraham, E.L. Klaiber 
15 Oct 1970-American Journal of Obstetrics and Gynecology
26 Citations
The above finding suggests that estrogens may play an important role in a midcycle surge of LH.
Journal Article•DOI
Suppression of spontaneous LH surges in estrogen-treated ovariectomized rats by microimplants of antiestrogens into the preoptic brain.
Sandra L. Petersen, Charles A. Barraclough 
10 Apr 1989-Brain Research
124 Citations
Since all estrogen-accumulating cells could be affected by this treatment, it is difficult to identify the site(s) at which this steroid acts to affect LH surges.
Journal Article•DOI
Effect of gonadotrophin-releasing hormone (GnRH) antagonist during the LH surge in normal women and during controlled ovarian hyperstimulation.
Sophie Christin-Maitre, F. Olivennes, S. Dubourdieu, Chabbert-Buffet N, B. Charbonnel, R Frydman, P. Bouchard 
01 Jun 2000-Clinical Endocrinology
24 Citations
Our results indicate that GnRH is required throughout the gonadotrophin surge in women, not only for the initiation but also for the maintenance of the LH surge.
Journal Article•DOI
Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH.
Howard E. Kulin, Edward O. Reiter 
01 Dec 1972-The Journal of Clinical Endocrinology and Metabolism
67 Citations
The results suggest that there is a differential suppressive effect upon FSH and LH by estrogen at threshold doses.

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