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Can you live without motor neurons?

Axoplasmic transport

Amyotrophic lateral sclerosis

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Open access•Journal Article•DOI Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. Nichole A. Reyes, Jill K. Fisher, Kathryn Austgen, Scott R. VandenBerg, Eric J. Huang, Scott A. Oakes - Show less +5 more 01 Oct 2010-Journal of Clinical Investigation 100 Citations	One possibility is that the affected motor neurons only succumb to apoptosis once they have exhausted functional capacity.
Open access•Journal Article•DOI Isolation of Mature Spinal Motor Neurons and Single-cell Analysis Using the Comet Assay of Early Low-level DNA Damage Induced In Vitro and In Vivo Zhiping Liu, Lee J. Martin - Show less +1 more 01 Aug 2001-Journal of Histochemistry and Cytochemistry 19 Citations	It shows that adult motor neurons can be isolated from in vivo models of motor neuron degeneration and evaluated on a single-cell basis.
Journal Article•DOI Pathological findings in a patient with amyotrophic lateral sclerosis and multifocal motor neuropathy with conduction block Bastiaan Veugelers, Paul Theys, Martin Lammens, Johan Van Hees, Wim Robberecht - Show less +4 more 01 Mar 1996-Journal of the Neurological Sciences 35 Citations	The prominent degeneration of motor neurons, however, must also have played a role in the clinical picture.
Journal Article•DOI Sensory afferents and motor neurons as targets for nitric oxide in the locust. Swidbert R. Ott, Ian W. Jones, Malcolm Burrows, Maurice R. Elphick - Show less +3 more 10 Jul 2000-The Journal of Comparative Neurology 40 Citations	Therefore, NO may modulate both the input from these sensory neurons and the output of motor neurons.
Journal Article•DOI Motor neuron disease in vitro: the use of cultured motor neurons to study amyotrophic lateral sclerosis P.R Bär 29 Sep 2000-European Journal of Pharmacology 33 Citations	Studies with isolated motor neurons may produce important information.
Journal Article•DOI Genetics of motor neuron disease. Ludo Van Den Bosch, Vincent Timmerman - Show less +1 more 01 Sep 2006-Current Neurology and Neuroscience Reports 24 Citations	We hypothesize that both phenomena are not only crucial for the normal functioning of motor neurons, but that they could also be interconnected.
Journal Article•DOI Ventral root avulsion: An experimental model of death of adult motor neurons Vassilis E. Koliatsos, William L. Price, Carlos A. Pardo, Donald L. Price - Show less +3 more 01 Apr 1994-The Journal of Comparative Neurology 278 Citations	The present study proposes a reproducible model of experimental degeneration of adult motor neurons in the rat.

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