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Can you still have your mucus plug after a membrane sweep? 

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Open accessJournal ArticleDOI
Bernadett Tildy, Duncan F. Rogers 
01 Jan 2015-Pharmacology
29 Citations
PCL layer dehydration reduces mucociliary clearance (MCC), leading to airway obstruction (reduced airflow and inflammation due to pathogen invasion) with mucus plug formation.
Mucus plugs are a plausible mechanism of chronic airflow obstruction in severe asthma, and EPO-generated oxidants may mediate mucus plug formation.
In contrast, after aerosol deposition on top of the mucus layer only particles with a size of 100 nm were able to penetrate into mucus, suggesting the presence of smaller pores at the air-mucus interface compared to within mucus.
Open accessJournal ArticleDOI
11 Citations
Expression of an apical chloride channel in these cells or in the mucus granule membrane would facilitate wash-out of mucus into the pericilliary fluid layer.
Mucus secretion may therefore be initiated by the interaction of mucus-releasing stimuli with fucosyl or galactosyl residues of specific membrane receptors.
This mucus plug can cause collapse of the lung and ill consequences.
Mucus secretions of the intestine may contribute to plug formation in CF, through several mechanisms acting alone or simultaneously.
Results show that, the maximum wall shear stress remarkably changes right prior to the rupture of the mucus plug.
Fluid dynamics of mucus plug rupture is important to understand mucus clearance in lung airways and potential effects of mucus plug rupture on epithelial cells at lung airway walls.
Mucus appears to have an important role in the genesis of bladder stones after augmentation, possibly acting as a nidus.

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