Do Ace 2 receptors increase with age?
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| In small intestinal mucosa, ACE2 mRNA expression appears to increase with age and to display higher levels in patients taking ACE-inhibitors (ACE-I). | |
Open access•Journal Article 18 Citations | From these results we conclude that beta 1 and beta 2 receptors are present in livers from rats of the three age groups and that the beta 1 to beta 2 receptor ratio is increased in livers from mature and senescent rats compared with newborn rats. |
29 Citations | These results suggest that extraneuronal uptake mechanisms increase with age and that presynaptic alpha 2 adrenoceptor-mediated autoregulation of NE decreases with age. |
| Receptors do not appear to change with age in certain systems, but only a few reports have actually been able to localize particular post-receptor alterations responsible for changes in response. | |
30 Citations | Although age-related decline in receptors has previously been observed in the mu opioid receptor system, we found that KOR availability does not change with age. |
23 Citations | To the authors' knowledge, the data here presented are the first ones which suggest that age may increase rather than decrease the number of neurotransmitter receptors in the brain. |
191 Citations | Most likely, AT2 receptors are located on endothelial cells, and their contribution increases with age. |
| We show age, sex, and comorbidities do not increase ACE2 protein expression in the human respiratory tract. | |
51 Citations | Population frequencies of ACE genotypes were also found to change with age, congruent with previous data suggesting effects upon longevity. |
67 Citations | Evidence suggests a decreased rate of receptor synthesis may be contributing to this loss of receptors with age. |
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