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Do neurofibrillary tangles kill neurons? 

Senile plaques
Ultrastructure
Nucleus basalis
Neurofibrillary tangle
Cerebral cortex

Answers from top 8 papers

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Papers (8)Insight
Book Chapter•DOI
Life and death of neurons in the aging cerebral cortex.
John H. Morrison, Patrick R. Hof 
01 Jan 2007-International Review of Neurobiology
119 Citations
The selective vulnerability of this neuron death is reflected in the characteristics of cortical pyramidal neurons that are prone to form neurofibrillary tangles.
Journal Article•DOI
Neurofibrillary tangle formation in the nucleus basalis of meynert ipsilateral to a massive cerebral infarct
Takeo Kato, Asao Hirano, Tadashi Katagiri, Hideo Sasaki, Shigeru Yamada 
01 Jun 1988-Annals of Neurology
65 Citations
Considering the widespread projection of nbM axons to the ipsilateral cerebral cortex, this suggests that formation of neurofibrillary tangles can occur as a retrograde reaction of nbM neurons secondary to massive, old cerebral infarction.
Journal Article•DOI
Neurofibrillary degeneration and neuronal loss in alzheimer's disease
William Bondareff, C.Q. Mountjoy, Martin Roth, Douglas L. Hauser 
01 Nov 1989-Neurobiology of Aging
109 Citations
In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles.
Journal Article•DOI
The cytoskeleton and neurofibrillary tangles in Alzheimer's disease
Christopher C. J. Miller, Margaret Haugh, Jacob Kahn, Brian H. Anderton 
01 Jan 1986-Trends in Neurosciences
24 Citations
Thus the study of the structure and composition of neurofibrillary tangles is an important area of research, since it may reveal how they are produced and so help to elucidate the degenerative processes which underlie this devastating disease.
Journal Article•DOI
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease
Neil W. Kowall, M F Beal 
01 Feb 1988-Annals of Neurology
212 Citations
In addition, it is apparent that these neurons can develop widespread morphological abnormalities in the absence of neurofibrillary tangle formation.
Journal Article•DOI
Motor neuron disease with neurofibrillary tangles in a non-Guamanian patient.
David A. Hilton, Seth Love, Ian Ferguson, Piers Newman 
01 Jan 1995-Acta Neuropathologica
14 Citations
The present findings further extend the spectrum of diverse neurological disorders associated with neurofibrillary tangles.
Journal Article•DOI
Mass and physical dimensions of two distinct populations of paired helical filaments
Hanna Ksiezak-Reding, Joseph S. Wall 
01 Jan 1994-Neurobiology of Aging
64 Citations
The results suggest that a similar process may be active in the formation of neurofibrillary tangles.
Journal Article•DOI
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques.
Haruyasu Yamaguchi, Yoichi Nakazato, Mikio Shoji, Yuetsu Ihara, Shunsaku Hirai 
01 Jan 1990-Acta Neuropathologica
66 Citations
The presence of these threads was closely associated with neurofibrillary tangle formation.

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