Do oncogenes affect tumor angiogenesis?
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Open access•Journal Article | Hence, pharmacologically targeting mutant ras oncogenes could conceivably suppress solid tumor growth in vivo, in part, by inhibiting tumor-induced angiogenesis. |
127 Citations | Thus, oncogenes may cause complex changes in the ability of GBM cancer cells to interact with the coagulation system, thereby exacerbating its influence on angiogenesis and disease progression. |
Open access•Journal Article | Recent data indicate that developmental and tumor angiogenesis can be induced by cellular oncogenes, leading to the enhanced activity of molecules stimulating angiogenesis. |
Open access•Journal Article | The results suggest that dominantly acting ras oncogenes may contribute to the growth of solid tumors in vivo not only by a direct effect on tumor cell proliferation but also indirectly, i. e., by facilitating tumor angiogenesis. |
Open access•Journal Article | However, activated oncogenes might also facilitate angiogenesis by down-regulating endogenous inhibitors of angiogenesis. |
| Although activated oncogenes increase tumor cell proliferation and decrease their apoptosis, these activities are not sufficient to expand tumor mass beyond a microscopic size. | |
| Oncogenes must also induce tumor angiogenesis for expansion of tumor mass. | |
23 Citations | We propose that normalization of the vascular network by targeting oncogenes in the tumor cells might lead to more efficient and sustained therapeutic effects compared to therapies targeting tumor vessels. |
| Indeed, the very first indication of a possible contributory role of oncogenes, such as ras and myc, to tumor angiogenesis was first reported by Thompson et al. | |
01 Dec 2000 | Thus, oncogenes can impact several interconnected aspects of cellular growth, survival, and angiogenesis. |
Related Questions
Types of Oncogenes?4 answersOncogenes are altered versions of proto-oncogenes that are involved in the regulation of cell growth and are activated by mutation, chromosomal rearrangement, or gene amplification. Approximately 20 different oncogenes have been reproducibly activated in various types of malignancies, including breast, colon, lung, pancreatic, and thyroid carcinomas, leukemias, and lymphomas. These oncogenes can serve as potential markers for early detection of cancer, depending on the stage of tumor development at which they are activated. In addition to deregulating cell proliferation or suppressing apoptosis, oncogenes may also play a role in cell lineage determination and the behavior of cancer stem cells. Alterations in the expression of oncogenes, tumor suppressor genes, and apoptosis-inducing genes are frequently observed in cancer cells and can impact the development and maintenance of malignant phenotypes. Restoring the normal function of these genes has shown promise as an effective means of cancer therapy, although effective delivery of these genes to cancer cells is crucial.
What is the role of angiogenesis in the progression of glioma tumors?5 answersAngiogenesis plays a crucial role in the progression of glioma tumors. Glioblastoma multiforme (GBM), a highly invasive and vascularized brain tumor, relies on angiogenesis for growth and survival. Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietins (Ang-1, Ang-2, and Ang-4) promote tumor angiogenesis and contribute to GBM progression. The formation of a microvascular network provides oxygen, nutrients, and growth factors to glioma cells, facilitating their proliferation, survival, and invasion. Abnormal activation of tumor angiogenesis and the mutation of isocitrate dehydrogenase are associated with higher anaplasia levels in anaplastic gliomas. Anti-angiogenesis therapies, such as targeting VEGF or using anti-angiogenic antibodies like bevacizumab, have shown clinical efficacy in GBM treatment by inhibiting tumor angiogenesis. However, therapeutic resistance and the activation of alternative angiogenesis pathways remain challenges in GBM treatment. Understanding the molecular basis of angiogenesis and identifying novel angiogenic factors may provide new therapeutic targets for controlling glioma progression.
What are most famous angiogenic motifs that have been studied recently?5 answersThe most famous angiogenic motifs that have been studied recently include the VHHQKLVFF sequence found in Abeta peptides, the C-terminal cystine knot motifs present in key angiogenic regulators such as Slit3, von Willebrand factor, platelet-derived growth factor-B, and VEGF-A, and the vascular endothelial growth factor (VEGF) which guides the growth of new blood vessels. These motifs have been shown to play important roles in angiogenesis, which is the formation and sprouting of new blood vessels from pre-existing vascular structures. The Abeta peptide sequence VHHQKLVFF has been found to exhibit potent anti-angiogenic effects and may have clinical relevance as an anti-angiogenic agent. The C-terminal cystine knot motifs, particularly those found in connective tissue growth factor (CCN2/CTGF), have been shown to promote angiogenesis and have therapeutic potential for antiangiogenesis. VEGF has been extensively studied for its role in guiding the growth of new blood vessels.
What are angiogenic motifs?3 answersAngiogenic motifs are sequences within proteins that play a role in the process of angiogenesis, which is the formation of new blood vessels from existing ones. These motifs can be found in various angiogenic factors and are involved in initiating specific events within the complex cascade of pathways that lead to angiogenesis. However, the exact nature and characteristics of angiogenic motifs are still being studied.
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