Do vaccines increase inflammatory markers?
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| Papers (10) | Insight |
|---|---|
46 Citations | Selection of additional inflammatory markers could provide for a better understanding of underlying immune changes. |
56 Citations | Vaccines containing adjuvants may be associated with an increased risk of autoimmune/inflammatory adverse events following immunization. |
29 Citations | Our data support the concept that facile measurement of antibody titers, particularly of subsets induced by proinflammatory cytokines, may also serve as useful surrogate markers of protection even for vaccines that function by inducing cell-mediated, rather than humoral, immunity. |
78 Citations | Inflammatory markers, such as C-reactive protein, may allow clinical insight into these decades-long processes, adding value to predictive measures of disease outcomes. |
123 Citations | These data suggest that recruiting inflammatory cells, including antigen-presenting cells (APCs), to the site of antigen production substantially improves the immunogenicity of DNA vaccines. |
28 Citations | This effect is associated with beneficial modulation of systemic inflammatory markers. |
| The use of inflammatory markers may also improve diagnosis of severe infection. | |
28 Citations | These results suggested that DNA vaccines could increase the IgG antibody level and induce the expressions of cytokines. |
28 Aug 2020 66 Citations | Data correlating clinical outcomes with laboratory markers of cell-mediated immunity, not only with antibody response, after SARS-CoV2 natural infection and vaccines may prove critically valuable if protective immunity fades or if new patterns of disease emerge. |
15 Citations | Improvement in inflammatory status is most likely to occur in persons with elevated levels of pro-inflammatory markers prior to intervention. |
Related Questions
What do studies on pro-inflammatory markers suggest during malaria infection?4 answersStudies on pro-inflammatory markers during malaria infection suggest that the levels of pro-inflammatory cytokines, such as TNF-α, IFN-γ, and IL-10, are elevated in infected individuals compared to uninfected individuals. These cytokines play a crucial role in the immune response to Plasmodium infection and are involved in disease progression, parasite killing, and mediating disease outcomes. The levels of pro-inflammatory cytokines are higher in individuals with severe malaria, particularly in those with cerebral malaria, compared to individuals with non-cerebral malaria. Additionally, oxidative stress, which is common in malaria, can trigger the inflammatory activation of macrophages through the production of reactive oxygen species (ROS) by xanthine oxidase (XO). This inflammatory response is associated with the development of severe organ dysfunction and a poor outcome in individuals with cerebral malaria. Overall, these studies highlight the importance of pro-inflammatory markers in malaria pathogenesis and suggest their potential as targets for therapeutic interventions.
What is the relationship between periodontitis and inflammatory markers?5 answersPeriodontitis is associated with increased levels of inflammatory markers. Studies have shown that patients with periodontitis have higher levels of C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), and toll-like receptors (TLRs) compared to individuals without periodontitis. Additionally, the neutrophil to lymphocyte ratio (NLR), platelet to leukocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) are higher in individuals with periodontitis, indicating systemic immune inflammation. These findings suggest that periodontitis is associated with an increased systemic inflammatory response, which may contribute to the development and progression of chronic inflammatory diseases. The presence of periodontal pathogens, such as Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Treponema denticola, Porphyromonas gingivalis, Prevotella intermedia, and Candida albicans, further exacerbates the inflammatory response in periodontitis. Overall, these studies highlight the relationship between periodontitis and inflammatory markers, emphasizing the importance of managing periodontal health to prevent systemic inflammation and associated diseases.
Are there any specific inflammatory markers that are elevated in women with PCOS?3 answersElevated levels of inflammatory markers have been observed in women with polycystic ovary syndrome (PCOS). Specifically, the following markers have been found to be elevated in PCOS women: IL-10, IL-17A, and CRP. IL-10 levels were significantly higher in PCOS women compared to healthy women. IL-17A levels were also significantly elevated in PCOS women. Additionally, CRP levels were found to be higher in women with PCOS. These findings suggest that inflammation plays a role in the pathogenesis of PCOS and may contribute to the associated metabolic and reproductive dysfunctions.
Can inflammation be present without inflammatory markers?5 answersInflammation can be present without inflammatory markers. Although sensitive indicators of inflammation, individual biomarkers generally lack the specificity to identify the cause of inflammation. Changes in hematology dynamics, acute-phase proteins, complement factors, and cytokines are common to virtually all inflammatory conditions, but they are not strongly associated with specific pathologic events. Inflammatory markers can be useful in diagnosing inflammatory diseases, monitoring disease activity, and predicting relapse. However, no single ideal marker exists, and further workup may be required to differentiate inflammatory bowel disease from other disorders. Therefore, while inflammatory markers can be helpful, they are not always present or specific enough to definitively indicate the presence of inflammation.
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