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Given the fact that apoptosis is a consequence of various cancer treatment modalities, this may lead to a suppression of local antitumor reactions and thus actually counteract endogenous immune-mediated tumor defense mechanisms.
Suppression of apoptosis might contribute to tumor development by means of accumulation of continuously proliferating cells.
Thus, inhibition of apoptosis does not lead to loss of genomic stability and creates tumor environment that no longer supports further tumor progression and inhibitors of apoptosis can be considered as factors suppressing tumor progression.
However, because the death of tumor cells induced by chemotherapy and radiotherapy is largely mediated by activation of apoptosis, inhibition of apoptosis will make tumor cells resistant to anti-tumor treatment.
In addition to its profound tumor-suppressive role, apoptosis can potentiate cancer progression.
These results suggest that the induction of apoptosis may be one role of APC in tumor suppression and that this mechanism is independent of β-catenin-mediated effects on transcription.
Apoptosis may play a major role in determining tumor growth and aggressiveness.
These studies have shown that apoptosis is an important response in some tumors, correlating with tumor growth delay and tumor cure.
In animal models Apoptin-induced apoptosis appears to be a safe and efficient anti-tumor agent.
Apoptosis alteration is responsible not only for tumor development and progression but also for tumor resistance to therapies.

Related Questions

Are there anti-cancer drugs affecting either proliferation or apoptosis ?5 answersThere are several anti-cancer drugs that affect either proliferation or apoptosis. Compounds derived from plants and marine species have shown potential as anti-cancer agents by inducing apoptosis and inhibiting cell growth and division. Calcium signaling plays a critical role in cellular processes and aberrant Ca2+-signaling contributes to tumor progression. Certain anti-cancer drugs modulate Ca2+-signaling-dependent mechanisms to suppress pro-survival signals and activate pro-apoptotic signaling. The cell cycle regulators and proliferation factors are targeted for the development of anti-cancer therapy. Proteins such as Cyclins, CDKs, CKI, and various kinases control cell division and their dysregulation is observed in cancer cells. Targeting these regulators with drug molecules has shown promise in inhibiting cancer progression. sp2-Iminosugar-type castanospermine analogues have been found to inhibit breast cancer cell viability and induce cell cycle arrest and apoptosis, making them potential anti-cancer agents. Compounds that interact with Tubulin subunits disrupt microtubule dynamics involved in mitosis and have potent anti-cancer activity.
How does the induction of apoptosis play a role in future cancer treatments?5 answersThe induction of apoptosis plays a crucial role in future cancer treatments. Apoptosis, or programmed cell death, is a mechanism that eliminates abnormal or damaged cells, including cancer cells. It is a target for developing novel anticancer drugs. Current research focuses on identifying targets upstream and downstream of apoptosis-related proteins and understanding the regulation of apoptosis pathways. Alterations in apoptosis pathways contribute to resistance to conventional anticancer therapies, so successful induction of apoptosis using novel therapeutics is important for preventing recurrence and metastasis. Histone deacetylases (HDACs) are enzymes that regulate gene transcription and their overexpression is found in some tumors. HDAC inhibitors induce apoptosis by acetylating non-histone proteins, such as Ku70, which plays a role in repairing DNA breaks and stabilizing anti-apoptotic and pro-apoptotic proteins. Overall, understanding and targeting apoptosis pathways can lead to the development of effective cancer treatments.
What are the mechanisms of cancer apoptosis?5 answersApoptosis, or regulated cell death, is a critical process in cancer treatment. It involves several pathways, including the intrinsic and extrinsic pathways, which converge at the executioner caspases. The Bcl-2 gene family plays a crucial role in regulating the intrinsic apoptotic pathway, controlling signals for cell survival and death. Anti-cancer therapies often target the apoptotic signaling pathways to trigger cancer cell death and prevent chemoresistance. BH3-mimetic drugs, which mimic the function of pro-apoptotic BH3-only proteins, have been developed to induce apoptosis in cancer cells by inhibiting apoptosis inhibitory proteins. Dysregulation of apoptosis is a key hallmark of cancer, and understanding the apoptotic signaling pathways is important for developing effective anti-cancer therapeutics. Pro-apoptotic and anti-apoptotic proteins, such as Bax and Bcl-2 family proteins, act as regulators in cell division and growth and are potential targets for developing therapeutics. Inactivation of apoptosis is a dysregulatory process in many cancer types, and research is focused on developing apoptosis-targeted therapeutics.
What is wrong in apoptosis during cancer?5 answersDefective apoptosis is a major issue in cancer, leading to the survival and proliferation of cancer cells. The abnormalities in apoptotic pathways, such as mutations in genes, evasion of apoptosis, and alterations in signaling pathways, contribute to the development and progression of cancer. The central players in the apoptotic mechanism are the Bcl-2 family of proteins and caspases, which regulate cell death. Dysregulation of these master regulators results in deficient apoptotic signaling and inadequate apoptosis in cancer cells, promoting carcinogenesis. Upregulation of anti-apoptotic proteins, such as Bcl-2 and Mcl-1, and loss of pro-apoptotic proteins, such as Bid, Bad, Bax, and Bak, contribute to apoptosis evasion in cancer cells. The ability of cancer cells to evade apoptosis is crucial for their clonal expansion and progression. Understanding the molecular mechanisms of defective apoptosis can aid in the development of novel therapeutic strategies for cancer treatment.
What is the role of the tumor suppressor gene p53 in apoptosis?5 answersThe tumor suppressor gene p53 plays a critical role in apoptosis. It regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, through transcriptional control of a broad gene network. Dysfunction in the p53 network is common in various cancers, often due to mutations that inactivate p53 or other members of the pathway. Restoring p53 activity has gained significant interest as a potential anti-cancer strategy. Several microRNAs (miRNAs) have been identified as effectors and regulators of p53, including miR-192, miR-194, miR-215, miR-22, and miR-101. These miRNAs can either up-regulate or down-regulate p53 and its target genes, influencing cell survival, cell cycle arrest, and apoptosis. Understanding the role of p53 and its regulation by miRNAs provides insights into the development of novel therapeutic targets for the diagnosis and treatment of human cancers.
Does Sugar prevent apoptosis?10 answers

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