Does apoptosis aid in tumor suppression?
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Open access•Journal Article 139 Citations | Given the fact that apoptosis is a consequence of various cancer treatment modalities, this may lead to a suppression of local antitumor reactions and thus actually counteract endogenous immune-mediated tumor defense mechanisms. |
Open access•Journal Article | Suppression of apoptosis might contribute to tumor development by means of accumulation of continuously proliferating cells. |
44 Citations | Thus, inhibition of apoptosis does not lead to loss of genomic stability and creates tumor environment that no longer supports further tumor progression and inhibitors of apoptosis can be considered as factors suppressing tumor progression. |
166 Citations | However, because the death of tumor cells induced by chemotherapy and radiotherapy is largely mediated by activation of apoptosis, inhibition of apoptosis will make tumor cells resistant to anti-tumor treatment. |
In addition to its profound tumor-suppressive role, apoptosis can potentiate cancer progression. | |
These results suggest that the induction of apoptosis may be one role of APC in tumor suppression and that this mechanism is independent of β-catenin-mediated effects on transcription. | |
33 Citations | Apoptosis may play a major role in determining tumor growth and aggressiveness. |
These studies have shown that apoptosis is an important response in some tumors, correlating with tumor growth delay and tumor cure. | |
In animal models Apoptin-induced apoptosis appears to be a safe and efficient anti-tumor agent. | |
27 Mar 2016 918 Citations | Apoptosis alteration is responsible not only for tumor development and progression but also for tumor resistance to therapies. |
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