Does bulking increase insulin resistance?
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93 Citations | This suggests increased muscle fatty acid uptake, which may favor insulin resistance. |
87 Citations | High intakes of saturated fats may promote insulin resistance. |
| If so, insulin resistance would worsen as the level of circulating insulin increases during compensation, which could contribute to the transition of insulin resistance to more severe disease. | |
143 Citations | Dietary weight loss, with or without exercise, significantly improved insulin resistance. |
| These in turn may contribute to the development of insulin resistance. | |
628 Citations | This may generate later muscle insulin resistance. |
| Insulin resistance appears to increase incrementally according to BMI levels primarily and body fat levels secondarily. | |
72 Citations | In fact, they increase insulin precisely to the degree needed to compensate for the fatty acid-induced insulin resistance. |
Open access 01 Jan 2008 155 Citations | There also is some indication that resistance exercise may be effective in preventing insulin resistance. |
346 Citations | In conclusion, our results indicate that insulin resistance is a common accompaniment of obesity and can be overcome at supraphysiological insulin concentrations. |
Related Questions
How can insulin resistance cause obesity?5 answersInsulin resistance can contribute to obesity through various mechanisms. One key mechanism is the excessive production of ATP in insulin-sensitive cells under obese conditions, which we refer to as "mitochondrial overheating". This ATP overproduction leads to systemic insulin resistance by inhibiting AMPK, inducing mTOR, and causing hyperinsulinemia and hyperglucagonemia. Additionally, insulin resistance is often associated with an excessive accumulation of adipose tissue, which can lead to the development of type 2 diabetes, arterial hypertension, atherosclerosis, and non-alcoholic fatty liver disease. Furthermore, oxidative stress, characterized by an imbalance between the production of reactive oxygen and nitrogen species and the capacity of the antioxidant defense system, is increased in obesity and can contribute to insulin resistance. Overall, insulin resistance plays a significant role in the development of obesity and its associated metabolic complications.
How to increase body mass?5 answersTo increase body mass, one can use a GDF-8 inhibitor to increase lean muscle mass by providing an exercise regimen and administering the inhibitor. Another method is to inhibit the human aromatase enzyme using Red Wine extracts containing Proanthocyanidins, which can lead to increased muscle mass and strength. Additionally, administering Phosphatidic acid, lyso-phosphatidic acid, and/or phospholipase D to exercising mammals can increase muscle mass and strength, especially when combined with resistance training.
How does excess insulin lead to weight gain?5 answersExcess insulin can lead to weight gain through various mechanisms. One possible mechanism is the conservation of previously excreted glucose, which can result in weight gain. Another mechanism is the defensive or unconscious increase in calorie intake caused by the fear or experience of hypoglycemia. Additionally, the "unphysiological" pharmacokinetic and metabolic profiles that follow subcutaneous insulin administration can contribute to weight gain. Insulin therapy can also lead to weight gain by reducing blood glucose levels without a compensatory reduction in calorie intake. Furthermore, insulin modulates the biochemical pathways controlling lipid uptake, lipolysis, and lipogenesis, which can contribute to weight gain. It is important to note that insulin-associated weight gain can be influenced by factors such as insulin sensitivity, activity levels, and the ratio of bolus to basal insulin doses.
Can overnutrition cause insulin resistance?5 answersOvernutrition can cause insulin resistance. Studies have shown that short-term exposure to high-nutrition diets can lead to blunted central responses to insulin and altered gut microbiome composition, even before the onset of obesity. Additionally, overnutrition diets can increase plasma membrane sn-1,2-diacylglycerol (DAG) content, which promotes protein kinase C-e (PKCe) activation and impairs insulin signaling. Maternal overnutrition during late gestation has also been found to predispose foals to metabolic disease, suggesting a link between overnutrition and insulin resistance. Furthermore, neonatal overfeeding has been shown to cause hepatic insulin resistance that persists into adulthood, potentially through epigenetic mechanisms involving histone modifications. These findings suggest that overnutrition can indeed lead to insulin resistance, highlighting the importance of dietary interventions and personalized therapies to prevent and improve metabolic disorders.
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