Does codeine affect GABA receptors?
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88 Citations | The data suggest that GABA, by activating specific receptors, causes inhibition of firing of dopaminergic neurones and the opposite effect on the noradrenergic neurones. |
43 Citations | Moreover, both selective GABA(B) receptor antagonist CGP35348 and selective GABA(A) receptor antagonist bicuculline were capable of partially blocking the inhibitory response of IN neurons to GABA (n = 14 and 11), suggesting that the GABA-induced inhibition may contain two components, a GABA(B) receptors-mediated component and a GABA(A) receptors-mediated one. |
| Here, we report that the brief GABA exposure induces a decrease in the percentage of α3-containing receptors, a receptor subtype that exhibits a high degree of coupling between GABA and benzodiazepine binding sites. | |
48 Citations | These results suggest that GABA affects the cholinergic transmitter release through bicuculline- and picrotoxin-sensitive receptors, showing low affinity toward the agonist. |
12 Citations | The presence of GABA(C) receptors in many GABAergic neurons suggests that this receptor type may be involved in the regulation of local inhibition. |
33 Citations | This study shows that the cyclopentane and cyclopentene analogues of GABA affect GABA(C) receptors in a unique manner, defining a preferred stereochemical orientation of the amine and carboxylic acid groups when binding to GABA(C) receptors. |
| Thus, by the criterion of being insensitive to both bicuculline and baclofen, both GABA receptors qualify as potential GABAC receptors. | |
28 Citations | It is then suggested that this effect might depend on an indirect activation of GABAB receptors through release of GABA. |
32 Citations | These functional and pharmacological differences between the two effects of GABA suggest that two separate receptors are involved. |
16 Citations | We can speculate that different subsets of GABA-B receptors are influenced by the two agonists but further studies are necessary. |
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