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Does coffee increase androgen receptors? 

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Open accessJournal ArticleDOI
04 Jul 2017-Planta Medica
206 Citations
Caffeine, e. g., in a cup of coffee, appears to exert most of its effects through an antagonism of the adenosine receptors.
An early and specific action of androgen is a remarkable increase of its own receptor.
Potential atheroprotective effects of testosterone could be secondary to (aromatase-mediated) conversion into oestradiol or, alternatively, to direct activation of androgen receptors (AR).
The results using flutamide, finasteride, cycloheximide, and actinomycin D indicate that androgen-induced potentiation is dependent on androgen receptors, requires reduction of testosterone to DHT, and occurs independently of transcriptional and translational events.
No associations between caffeinated beverage consumption and androgen or estrogen concentrations were observed. Men who drink coffee more frequently may have higher circulating SHBG concentration, but there were no consistent associations for soft drinks or caffeine intake.
The ability of testosterone to affect apparent intracellular distribution of cardiovascular androgen receptors suggests that the receptors are physiologically functional and indicates that androgen may directly regulate cardiovascular cell function.
On the other hand, the coffee‐induced increase of plasma epinephrine may increase the pressor response to coffee.
This result suggests that the androgen pathway has a significant effect in exercise-induced muscle hypertrophy and emphasizes the importance of the increase in the number of androgen receptors in exercised muscle.
These findings suggested that a rapid increase in the number of androgen receptors occurred as an early event for a practical increase in muscle mass and thus it may have contributed in part to the triggering of muscle hypertrophy by enhancing the muscle sensitivity to androgen.
Thus, androgen-induced androgen-receptor augmentation is explained by an increase both in receptor half-life and in rates of receptor synthesis.

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