Does endostatin inhibit angiogenesis?
Answers from top 10 papers
More filters
| Papers (10) | Insight |
|---|---|
4 Citations | In summary, our study demonstrated that endostatin inhibited angiogenesis. |
| We hypothesize a rise in Endostatin levels may reflect inhibition of adaptive angiogenesis and adverse cardiac remodeling. | |
21 Citations | Human endostatin can inhibit the initiation of a human angiogenic response and inhibit the subsequent proliferation of human neovessels when used at high doses in a continuous exposure model. |
18 Citations | Endostatin can inhibit tumor growth and angiogenesis by blocking Vegf/Flk-1 pathway. |
72 Citations | These findings demonstrate that endogenous endostatin is an inhibitor of induced angiogenesis and that administration of endostatin potently inhibits CNV growth and vascular leakage. |
43 Citations | In summary, endostatin gene therapy effectively suppressed angiogenic processes in vitro and in vivo in several model systems. |
33 Citations | Endostatin showed convincing inhibitory effects on angiogenesis both in vitro and in vivo. |
51 Citations | The mechanism of action of endostatin in inhibition of angiogenesis and thereby, inhibition of tumor growth, involves apoptosis of tumor cells. |
32 Citations | In addition, these results confirm the activity of endostatin as a potent anti-angiogenic agent. |
11 Citations | The results suggest that endostatin inhibits tumor angiogenesis in vivo in a species-specific manner. |
Related Questions
What is the effect of Irisin on angiogenesis?4 answersIrisin has been shown to have a positive effect on angiogenesis. In various studies, irisin administration has been found to promote angiogenesis in different contexts. In a study on retinal neovascularization, irisin was found to attenuate pathological angiogenesis in vivo and decrease VEGFA production in vitro. Another study on bone fracture healing found that irisin treatment increased vessel surface and vessel volume fraction in the fracture callus, indicating enhanced angiogenesis. In the context of acute myocardial infarction, irisin administration enhanced angiogenesis of bone marrow mesenchymal stem cells (BMSCs) and promoted cardiac function. Additionally, irisin was found to promote angiogenesis in human dental pulp cells, as evidenced by increased expression of angiogenic markers and enhanced cell migration. These findings suggest that irisin has a positive effect on angiogenesis in various tissues and could potentially be used to promote angiogenesis in different clinical settings.
What is the role of myostatin in type 2 diabetes?5 answersMyostatin plays a role in type 2 diabetes by being associated with diabetic retinopathy and metabolic parameters. Serum myostatin levels were found to be significantly higher in individuals with diabetic retinopathy compared to those without. In type 2 diabetes patients, myostatin levels were negatively related to fasting plasma glucose and triglyceride levels, while irisin levels showed a positive association with these variables. Additionally, myostatin inhibition improved bone regeneration and osteogenic differentiation in diabetic mice, suggesting its importance in bone metabolism. Pre-intervention of rAAV-mediated expression of myostatin propeptide (MPRO) prevented high-fat diet-induced hyperglycemia and hyperlipidemia, improved glucose tolerance, and reduced the incidence of type 2 diabetes. These findings suggest that myostatin may have a role in diabetic complications, metabolic parameters, and bone healing deficiencies in type 2 diabetes.
How does retinol help in anti-angiogenesis?5 answersRetinol, also known as vitamin A, plays a role in anti-angiogenesis. It helps inhibit the formation of new blood vessels, a process known as angiogenesis, which is important in various diseases including diabetic retinopathy and age-related macular degeneration (AMD). In diabetic retinopathy, retinol can help prevent the development of abnormal blood vessels in the retina, which can lead to vision loss. In AMD, retinol can help inhibit the growth of abnormal blood vessels under the retina and macula, which can cause central vision loss. Additionally, retinol has been found to have anti-angiogenic effects in other diseases related to angiogenesis, such as hemangioma, psoriasis, rheumatoid arthritis, and menstrual disorders. Overall, retinol's ability to inhibit angiogenesis makes it a potential therapeutic option for various angiogenesis-related diseases.
How anti angiogenesis work?4 answersAnti-angiogenesis therapy is a method used in cancer treatment to inhibit the formation of new blood vessels, thereby reducing the nutrient and oxygen supply to the tumor. This therapy is often combined with other strategies such as chemotherapy and radiotherapy to enhance its effectiveness. Angiogenesis, the process of blood vessel formation, plays a crucial role in tumor growth and progression. By targeting angiogenesis, anti-angiogenic agents aim to normalize the microvascular network of tumors. These agents can decrease the density of capillaries in tumors of different sizes, leading to a reduction in microvascular density. The effectiveness of anti-angiogenic treatment may depend on the size and progression stage of the tumor. Overall, anti-angiogenesis therapy works by disrupting the angiogenic process and inhibiting the growth and spread of tumors.
Does VEGF inhibit angiogenesis?10 answers
Is anti angiogenic therapy effective?10 answers