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Does fenugreek seeds increase estrogen?

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Journal Article•DOI Aqueous fenugreek seed extract ameliorates adriamycin-induced cytotoxicity and testicular alterations in albino rats. Saber A. Sakr, Salama M. El-shenawy, Ahmed M. Al-Shabka - Show less +2 more 01 Jan 2012-Reproductive Sciences 23 Citations	In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.
Journal Article•DOI Hypocholesterolaemic effect of fenugreek seeds in dogs. Guy Valette, Yves Sauvaire, Jean-Claude Baccou, Gérard Ribes - Show less +3 more 01 Jan 1984-Atherosclerosis 147 Citations	In conclusion, the defatted portion of fenugreek seed induces a hypocholesterolaemic effect.
Journal Article•DOI The Effect of Fenugreek ( Trigonella foenum-graecum) Seed and 17-β Estradiol on Serum Apelin, Glucose, Lipids, and Insulin in Ovariectomized Rats Mahmood Abedinzade, Sima Nasri, Masome Jamal Omidi, Bizhan Porramezan, Korosh Khanaki - Show less +4 more 24 Aug 2015-Biotechnology and Health Sciences 8 Citations	It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin.
Journal Article•DOI Effects of phytoestrogens genistein and daidzein on progesterone and estrogen (estradiol) production of human term trophoblast cells in vitro Dagmar Ulrike Richter, Ioannis Mylonas, Bettina Toth, Christoph Scholz, Volker Briese, Klaus Friese, Udo Jeschke - Show less +6 more 07 Jul 2009-Gynecological Endocrinology 30 Citations	Stimulation of estrogen production by genistein and daidzein in trophoblast cells is probably due to estrogen receptor blocking effects of both phytoestrogens.
Journal Article•DOI Identification and quantification of flavonoid glycosides from fenugreek (Trigonella foenum-graecum) germinated seeds by LC–DAD–ESI/MS analysis Zakia Benayad, Carmen Gómez-Cordovés, Nour-Eddine Es-Safi - Show less +2 more 01 Aug 2014-Journal of Food Composition and Analysis 50 Citations	Germinated fenugreek seeds could be considered as a rich source of bioactive phenolic compounds.

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Does fenugreek increase the bioavailability of curcumin?4 answersFenugreek has been shown to increase the bioavailability of curcumin. A novel formulation called curcumagalactomannoside (CGM), which combines curcumin with fenugreek galactomannan dietary fiber, has been developed to address the poor pharmacokinetics of curcumin. Studies have demonstrated that CGM improves the bioavailability and tissue distribution of curcumin, leading to enhanced clinical outcomes compared to unformulated curcumin. In vitro release studies have shown that curcumin released slowly and in a prolonged manner from CGM formulations. Animal and human studies have also confirmed the enhanced bioavailability of curcumin from CGM formulations compared to unformulated curcumin. Additionally, CGM supplementation has been found to have antioxidant, anti-inflammatory, and anti-arthritic effects in experimental models. Overall, the scientific evidence suggests that fenugreek-based formulations, such as CGM, can increase the bioavailability of curcumin and improve its therapeutic efficacy.

What is the evidence for the combination of curcumin and fenugreek?5 answersThe combination of curcumin and fenugreek has shown promising effects in various studies. In a study by Herrick et al., it was found that curcumin combined with fenugreek soluble fiber might delay neuromuscular fatigue. Another study by Subbuvel and Kavan demonstrated that the addition of curcumin and fenugreek essential oil to a composite film improved its functional properties, including UV-blocking, tensile strength, and antibacterial properties. Additionally, a study by Alberto Boretti suggested that curcumin may be associated with radiation therapy as a radiosensitizer for cancer cells and a radioprotector for normal cells, potentially reducing side effects. Furthermore, a study by Abo El-Nasr et al. found that the combination of curcumin and fenugreek extract improved bone loss in ovariectomized rats, showing a synergistic effect on bone turnover and strength. Overall, these studies provide evidence for the beneficial effects of combining curcumin and fenugreek in various applications.

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