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Does fungal cause inflammation? 

10 answers found

Although inflammation is an essential component of the protective response to fungi, its dysregulation may significantly worsen fungal diseases and limit protective antifungal immune responses.


Fungi can cause diseases mediated by MCs and aggravate allergic inflammation.

Impact of Fungi on Immune Responses.
01 Jun 2018Clinical Therapeutics      11 citations

These effects may create a vicious cycle in which low-level inflammation promotes fungal colonization and fungal colonization promotes further inflammation.


Superficial fungal infections affect 20–25% of people worldwide and can cause considerable morbidity, particularly if an inflammatory component is present.


These new findings provide a molecular connection between the failure to resolve inflammation and lack of antifungal immune resistance, and point to strategies for immune therapy of fungal infections that attempt to limit inflammation in order to stimulate an effective immune response.


Therefore, a major consequence of Candida-induced glucose starvation in macrophages is activation of inflammatory responses, with implications for understanding how metabolism modulates inflammation in fungal infections.


Low, but persistent inflammation, caused by environmental factors, such as fungal toxins, leads to irritation and sensitization, and could be responsible for allergic manifestations which, in turn, could lead to mucosal hyper-reactivity.


We demonstrate that the absence of C3 impairs fungal clearance but does not affect inflammatory responses.


Furthermore, our findings reveal two different fungal-host interaction strategies according to fungal morphotype, highlighting fungal dimorphism as an important key in understanding the bipolar nature of inflammatory response in fungal infections.