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They may link obesity with insulin resistance.
Its deficiency may increase insulin resistance, especially in patients with metabolic syndrome or type 2 diabetes.
Insulin resistance seems to influence the outcome.
There also is some indication that resistance exercise may be effective in preventing insulin resistance.
PA itself seems to enhance insulin resistance.
The reduction in insulin resistance might have therapeutic benefits for patients with non-insulin-dependent diabetes, obesity and the metabolic syndrome.
This effect together with other characteristics may lead to improved insulin resistance and glucose control.
No significant associations were found when insulin resistance was assessed as a continuous variable. The results of this cross-sectional study support the concept that diets with a higher GL are associated with an increased risk of insulin resistance.
Open accessJournal Article
Yoshikazu Tamori, Masato Kasuga 
825 Citations
Intervention which decreases inflammation may be useful treatment for insulin resistance.
Insulin resistance appears to mediate this association.