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Insulin has a moderate protective effect on subsequent counterregulation.
This effect seems not to be mediated by insulin, since HI had no effect on appetite.
I have discovered another effect of insulin on GABA(A) currents.
This may have limited any anabolic effect of insulin on protein synthesis.
We conclude that whilst insulin does not have a direct effect on ATBF, it is likely to be an important mediator, possibly acting via sympathetic activation.
So, H(2)S may have some effect on insulin secretion.
The results indicate favorable effect of insulin on ovarian function.
This effect of insulin is independent of its effect on glucose uptake.
Open accessJournal ArticleDOI
01 Jan 1982-Diabetologia
15 Citations
The evidence strongly suggests that phenothiazines influence insulin secretion by their effect on calmodulin which probably mediates calcium-dependent insulin release.
This supports a biologically important effect of insulin metabolism and insulin degradation products on insulin action on non-glucose pathways.

Related Questions

How insulin act on adipose tissue?5 answersInsulin acts on adipose tissue by regulating gene expression, specifically clock genes, in both murine and human adipocytes and adipose-derived stem cells (ASCs). Insulin also plays a role in the regulation of adipose tissue physiology, including energy and lipid metabolism, through the activation of the insulin receptor (INSR). It inhibits nonesterified fatty acid (NEFA) flux by inhibiting intracellular triglyceride (TG) lipolysis in adipose tissues, which is essential for preventing diabetic ketoacidosis and limiting lipotoxic effects. Insulin also regulates adipose tissue fatty acid esterification, glycerol and TG synthesis, lipogenesis, and possibly oxidation, contributing to the trapping of dietary fatty acids. Additionally, insulin directly entrains circadian clocks in adipose tissue and isolated adipocytes, representing a primary mechanism of feeding-induced adipose tissue clock entrainment. The insulin receptor isoforms, INSR-A and INSR-B, are involved in the regulation of adipose tissue development and function, with an altered INSR-A:INSR-B ratio contributing to metabolic abnormalities and insulin resistance.
What is the effect of insulin?2 answersInsulin has various effects on the body. It can suppress inflammatory changes and decrease vascular inflammation. Insulin also influences rates of glucose utilization by muscle and other tissues, controls fatty acid mobilization and oxidation, and affects insulin-like growth factors. In healthy subjects, insulin enhances coronary vasodilation, but its effect on Type I diabetic patients is unclear. Insulin is a potent growth factor, promoting cell growth and division, although its physiological importance in humans is uncertain. Insulin therapy can cause rare adverse effects such as insulin neuropathy, resulting in severe neuropathic pain.
What is the effect of insulin in diabetes?3 answersInsulin has various effects in diabetes. It suppresses inflammatory changes and reduces vascular inflammation, which could lead to vascular damage. Insulin has been hypothesized to cause sodium retention, but recent evidence suggests that it does not contribute to hypertension. Insulin enhances coronary vasodilation in healthy subjects, but its ability to induce coronary vasodilation in Type I diabetic patients is still being studied. Elevated insulin levels are associated with an increased incidence of cardiovascular disease, and insulin has been implicated in the development of atherosclerosis. Insulin resistance plays a critical role in the development of cardiovascular disease in patients with type 2 diabetes. It leads to small, dense LDL cholesterol, vascular smooth muscle proliferation, impaired nitric oxide-mediated vasodilation, and increased thrombosis.
What is the effect of insulin treatment in diabetes?2 answersInsulin treatment in diabetes has revolutionized diabetes management and is essential for the survival of patients with type 1 diabetes. It is also needed in a significant number of people with type 2 diabetes to optimize glycemic control. Insulin therapy has been shown to significantly reduce glycated hemoglobin levels. However, insulin therapy can have potentially life-threatening side effects such as hypoglycemia and increased risk of cardiovascular disease. The timing of insulin administration is crucial as tissue insulin sensitivity varies considerably throughout the day. Understanding the mechanisms underlying photic control of insulin action is of paramount importance. Initiating and advancing insulin therapy in type 2 diabetes requires careful consideration. There are barriers to initiating insulin therapy, both from the patient and provider perspectives, which need to be addressed.
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