scispace - formally typeset
Search or ask a question

Answers from top 10 papers

More filters
Papers (10)Insight
These results indicate that diet and not aging per se caused insulin resistance.
In contrast, it is evident that MIF expressed in adipose tissues causes insulin resistance.
Insulin resistance with resultant hyperinsulinaemia, irrespective of excess weight or frank obesity, has been reported in patients with PCOS, and, as insulin has a direct effect on ovarian androgen production in vitro, insulin resistance may play a crucial role in the physiopathology of PCOS.
This depletion may contribute to a post-receptor insulin resistance.
In conclusion, MI induces myocardial insulin resistance (without systemic insulin resistance) mediated partly by ischemia-induced myocardial TNF-α overproduction and promotes the development of HF.
The observation that M loaded on both factors suggests that a resistance to insulin action may provide the mechanism uniting the features of the insulin resistance syndrome.
Insulin resistance is probably associated with impairment in centrally mediated insulin suppression of EGP.
Interestingly, targeted disruption of Mio specifically in the insulin-producing cells (IPCs) has little effect on nutrient storage, but increases food consumption suggesting that Mio acts in these neurons to control feeding behavior.
Insulin resistance may be a consequence of hyperglycemia and/or obesity.
These results suggest a possible role for dietary magnesium in insulin resistance.

See what other people are reading

What is the normal ggt level in healthy young adults?
5 answers
In healthy young adults, the normal Gamma Glutamyl Transferase (GGT) levels typically range between 26.20 to 64.2 IU/L. Elevated GGT levels have been associated with various cardiovascular risk factors, including obesity, hypertension, dyslipidemia, and hyperglycemia. Additionally, GGT has been linked to oxidative stress, atherogenesis, and liver dysfunction, making it a valuable marker for assessing health status. Studies have shown that GGT levels can be influenced by factors like alcohol consumption, with even low levels of regular ethanol intake leading to elevated GGT activities, especially in individuals over 40 years of age. Therefore, monitoring GGT levels in young adults can provide insights into their cardiovascular and metabolic health status.
What to expect when starting metformin?
4 answers
When starting metformin, individuals can expect various effects and outcomes based on the available research. Metformin is known to have a significant favorable effect on weight and lipid profile even after just 3 months of use, without impacting liver function. Gastrointestinal adverse effects like diarrhea, nausea, and abdominal discomfort are common, especially at the beginning of therapy, and may persist even after years of stable use. Some patients may struggle with gastrointestinal intolerance to metformin, leading to difficulties in maintaining the medication. However, metformin is generally well-tolerated, with low risks of serious adverse events, and offers benefits beyond glucose control, including potential cardioprotective and anti-aging effects. Overall, metformin's effects can vary from weight and lipid improvements to gastrointestinal issues, but it is generally considered a valuable first-line therapy for type 2 diabetes.
What is the normal ggt level in young adults?
5 answers
The normal GGT (Gamma-glutamyl transferase) level in young adults can vary based on gender and health status. Studies have shown that in healthy young men, a GGT level cut-off of 20 U/l is indicative of either heavy alcohol use or being overweight. Elevated GGT levels have been associated with cardiovascular risk factors, including obesity, hypertension, dyslipidemia, and hyperglycemia in young adults. Additionally, GGT has been linked to oxidative stress and atherogenesis, suggesting its role as a marker for various health conditions. Therefore, while the specific normal range may vary slightly between studies, a GGT level below 20 U/l is generally considered normal in young adults, with higher levels indicating potential health risks.
What is the current state of international journal glucose research?
5 answers
The current state of international journal glucose research reflects a growing concern over the impact of high blood glucose levels on various health aspects. Studies indicate that diabetes, both type I and type II, is on the rise globally, leading to complications such as neuropathy, nephropathy, retinopathy, and osteopathy. Research efforts are focused on understanding the link between diabetes and cardiovascular complications, as current treatments do not adequately address the diabetes-specific risks of cardiovascular diseases. Additionally, investigations into potential anti-diabetic agents from natural sources like Samanea saman plant extracts show promising results in reducing blood glucose levels and inhibiting α-amylase activity. These findings underscore the importance of advancing knowledge in glucose-related research to develop improved strategies for prevention and care in diabetic patients.
Can jaboticaba prevent obesity?
5 answers
Jaboticaba, particularly its peel and seed powder, shows promising potential in preventing obesity-related disorders. Studies indicate that supplementation with jaboticaba components can attenuate weight gain, reduce fat accumulation, improve glucose metabolism, and enhance insulin sensitivity in obese mice. Furthermore, jaboticaba peel supplementation has been linked to decreased fat weight gain, improved insulin sensitivity, and reduced tau phosphorylation in the hippocampus, leading to better cognitive functions. Additionally, jaboticaba extract has demonstrated the ability to balance hormonal signaling, inhibit angiogenesis, and maintain healthy prostate morphology, suggesting a potential role in preventing prostatic lesions associated with aging and high-fat diets. Overall, the bioactive compounds in jaboticaba exhibit anti-obesity properties by modulating various metabolic pathways and physiological responses.
Can jaboticaba treat obesity?
4 answers
Jaboticaba, particularly its peel and seed powder, shows promise in treating obesity-related disorders. Studies indicate that supplementation with jaboticaba peel and seed powder can attenuate weight gain, reduce fat accumulation, improve glucose metabolism, and enhance insulin sensitivity in obese mice. Additionally, jaboticaba extract has been found to balance hormonal signaling, inhibit angiogenesis, and maintain healthy prostate morphology in aged or high-fat diet-fed mice, suggesting a potential role in preventing prostatic lesions. Furthermore, supplementation with jaboticaba peel in a high-fat diet has shown to prevent fat weight gain, improve insulin sensitivity, reduce tau phosphorylation in the hippocampus, enhance learning/memory performance, and counteract cognitive impairment caused by high-fat diet intake. These findings collectively support the therapeutic potential of jaboticaba in addressing obesity and related metabolic disturbances.
Is stevia glucose good for people with diabetes?
4 answers
Stevia, a natural herb, has shown promising benefits for individuals with diabetes. Research indicates that stevia has antidiabetic properties, including lowering blood glucose levels effectively at certain doses. Moreover, stevia is considered safe for diabetics and may have therapeutic effects when used at pharmacological doses, although further detailed studies are required. Stevia's compounds like steviol and rebaudioside A can significantly reduce sugar levels and oxidative stress, thus lowering the risk of diabetes. Clinical trials have demonstrated that stevia can be a suitable sugar substitute for diabetic patients, potentially helping in managing blood glucose levels and aiding in weight loss. Therefore, incorporating stevia as a sugar alternative in the diet of individuals with diabetes can be beneficial in controlling blood sugar levels and supporting overall health.
Can acetyl N glucosamine release energy in metabolism?
5 answers
Yes, N-acetylglucosamine can release energy in metabolism. Research indicates that N-acetylglucosamine stimulates insulin secretion, affects cellular ATP levels, and alters adenine nucleotide balance in muscle cells. Furthermore, N-acetylglucosamine metabolism by oral biofilm bacteria like Streptococcus mutans results in the production of ammonia, which can neutralize cytoplasmic pH and increase acid tolerance, contributing to enhanced persistence and pathogenic potential. Additionally, glucosamine, a related compound, can contribute to insulin resistance and interfere with glucose metabolism, favoring the hexosamine biosynthetic pathway and increasing the synthesis of UDP-N-acetylglucosamine, impacting leptin mRNA synthesis in muscle and adipocytes. Therefore, N-acetylglucosamine can indeed play a role in releasing energy within metabolic processes.
Is stress a symptom of magnesium deficinacy?
5 answers
Stress can be both a cause and a symptom of magnesium deficiency. Research indicates a bidirectional relationship between stress and magnesium levels, where stress can lead to increased magnesium loss, potentially causing deficiency. Conversely, magnesium deficiency can exacerbate the body's response to stress, creating a vicious cycle. Magnesium plays a crucial role in regulating neurotransmission and the physiological stress response, with low magnesium status often observed in individuals experiencing psychological stress. Furthermore, stress can contribute to conditions like headaches, fatigue, and neurotic disorders, which are also associated with magnesium deficiency. Therefore, addressing magnesium levels is essential in managing stress-related symptoms and promoting overall well-being.
Effect of ethlen on Diospyros kaki?
5 answers
Ethrel treatment on Diospyros kaki (persimmon) has varying effects based on the concentration used. Higher concentrations (150 or 200 ppm) led to increased physiological loss in weight and ethylene injury, while lower concentrations (50 or 100 ppm) showed no such issues when stored refrigerated. Additionally, an ethanolic extract of Diospyros kaki improved cognitive impairment in diabetic mice, reducing blood glucose levels and enhancing cognitive function. Furthermore, an acetone extract of Diospyros kaki leaves enhanced cell differentiation in leukemia cells, suggesting a potential role in acute promyelocytic leukemia therapy. Lastly, persimmon extracts protected PC12 cells from ischemic damage by reducing intracellular reactive oxygen species, hinting at neuroprotective potential against ischemic and neurodegenerative disorders.
What is the relationship between SIRT and diabetes?
5 answers
Sirtuins, particularly SIRT1, play a crucial role in the pathogenesis of diabetes mellitus (DM). SIRT1 is involved in DNA repair, stress response, and inflammatory processes, impacting the development of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. Studies have shown that SIRT1 gene polymorphisms are significantly associated with the development and progression of DN, indicating its importance in DM complications. Furthermore, SIRT1 is linked to insulin signaling pathways and energy homeostasis, exerting protective effects on kidney cells. The dysregulation of metabolic pathways in DM can be ameliorated by pharmacological activation of sirtuins, highlighting their potential as therapeutic targets for managing diabetes.