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Does mitochondrial fission affect ageing or aging? 


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Mitochondrial fission plays a role in aging, as changes in mitochondrial dynamics, specifically an increase in fission, have been observed during aging processes . This shift towards fission contributes to the loss of stem cells and tissue degeneration associated with aging . However, the exact role of mitochondrial fission in aging is still not fully understood, as conflicting data exist in the field . It is suggested that perturbations in the balance of mitochondrial fission and fusion, as well as impaired removal of nonfunctional mitochondria, can lead to an increase in dysfunctional mitochondrial elements, which may contribute to various pathologies, including aging . Overall, altered mitochondrial dynamics, including fission, are observed in aging and age-related diseases, but further research is needed to fully understand the causal relationship between mitochondrial fission and aging .

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The paper suggests that perturbation of the mitochondrial fission/fusion machinery and slowdown of the removal process of nonfunctional mitochondrial structures can lead to various pathologies, including aging. Therefore, mitochondrial fission may affect aging.
Mitochondrial fission affects aging processes, as a dynamic balance of fission and fusion events is required for sustaining critical cellular functions and regulating cell cycle progression.
Mitochondrial fission affects aging, as the paper states that during aging of Drosophila ovarian germline stem cells, mitochondrial dynamics shift towards fission and contribute to aging-related stem cell loss.
The paper states that both excessive and insufficient mitochondrial fission can negatively impact skeletal muscle mass and mitochondrial health in aged mice. Therefore, mitochondrial fission does affect aging.

Related Questions

What is the role of mitochondria in health abd ageing?5 answersMitochondria play a crucial role in cellular bioenergetics, metabolic regulation, calcium regulation, immune signaling, and apoptosis, making them fundamental for cellular metabolism and homeostasis. Mitochondrial dysfunction and disruptions in cellular bioenergetics have been implicated in various diseases, including type 2 diabetes, cardiovascular disease, metabolic syndrome, cancer, and Alzheimer's disease. Mitochondrial dysfunction is also associated with aging and age-related degenerative diseases, such as neurodegenerative diseases, osteoarthritis, metabolic diseases, and cardiovascular diseases. The accumulation of damage to cellular components and decline in physiological functions during aging is linked to mitochondrial dysfunction. Mitochondrial alterations have been shown to contribute to age-associated loss of function and the development of age-related diseases. Understanding the molecular mechanisms underlying mitochondrial dysfunction in aging and disease may provide important targets for interventions to prevent or treat these conditions.
Does mitochondrial fission affect obesity?4 answersMitochondrial fission plays a significant role in obesity. Dysregulation of mitochondrial dynamics and biogenesis, including increased mitochondrial fragmentation and decreased fusion, has been observed in animal models of obesity and diabetes. This abnormal mitochondrial fission leads to mitochondrial dysfunction, insulin resistance, and metabolic disorders. Additionally, ceramide-induced mitochondrial fission has been shown to drive high-fat diet-induced obesity. On the other hand, physical activity has been found to modify mitochondrial dynamics processes, such as fission and mitophagy, and can help maintain a healthy mitochondrial population, potentially counteracting the mitochondrial damage caused by obesity. Overall, these findings suggest that mitochondrial fission is closely associated with obesity and its related metabolic complications.
How does mitochondrial DNA affect weight loss?4 answersMitochondrial DNA (mtDNA) is associated with weight loss. Bariatric surgery-induced weight loss is linked to increased levels of mtDNA-CN, which is a surrogate measure of mitochondrial function. In a study on metformin response, higher mtDNA-CN was associated with greater weight loss in patients receiving metformin treatment. Additionally, higher levels of urinary cell-free mtDNA (cfmtDNA) were found in older adults with HIV who experienced unintentional weight loss. Variants in mitochondrial genes, such as Cytochrome c oxidase subunit genes and NADH dehydrogenase subunit genes, have been associated with BMI and weight gain. Lifestyle interventions, such as dietary changes, exercise, and smoking cessation, as well as clinical interventions like bariatric surgery, can also impact mitochondrial health and potentially contribute to weight loss.
Can mitochondrial mitochondrial fusion and fission be targeted as a therapeutic strategy for OA?5 answersMitochondrial fusion and fission have emerged as potential therapeutic targets for various diseases, including heart failure and abdominal aortic aneurysm (AAA). In heart failure, the imbalance in mitochondrial dynamics, specifically the loss of fission-fusion balance, contributes to impaired cardiac bioenergetics. Pharmacological strategies that aim to restore mitochondrial dynamics have shown promise in improving cardiac function and prognosis. In AAA, excessive mitochondrial fission mediated by dynamin-related protein 1 (Drp1) plays a role in disease development. Inhibiting mitochondrial fission with a specific inhibitor, mdivi1, attenuated AAA size and associated pathology. These findings suggest that targeting mitochondrial fusion and fission pathways could be a potential therapeutic strategy for diseases such as heart failure and AAA. However, further research and clinical studies are needed to validate the effectiveness of these strategies in improving mitochondrial morphology, metabolism, and disease outcomes.
What is role of Drp1 GTPase domain in mitochondrial fission?5 answersThe GTPase domain of Drp1 plays a crucial role in mitochondrial fission. Mutations in this domain can impair GTP hydrolysis and decrease GTPase activity. However, these mutations do not completely abolish self-assembly of Drp1 on lipid templates. The GTPase domain also contributes to the interactions that drive membrane curvature. The G32A mutation in the GTPase domain impairs GTP hydrolysis but still allows self-assembly on lipid templates. The G223V mutation in the GTPase domain also impairs GTPase activity and membrane remodeling of liposomes. These findings suggest that the GTPase domain of Drp1 is involved in both self-assembly and membrane remodeling, which are essential for proper mitochondrial fission.
Are mitochondrial damage-associated molecular patterns (Mito-DAMPs) involved in aging?5 answersMitochondrial damage-associated molecular patterns (Mito-DAMPs) are involved in aging. They are released from mitochondria during mild damage and can induce an immune response and the release of pro-inflammatory cytokines. Mitochondrial dysfunction, inflammation, and oxidative stress are considered key risk factors in aging and neurodegenerative disorders. The accumulation of oxidized by-products and the decline in mitochondrial quality control (MQC) contribute to aging. Mitochondrial-derived vesicles (MDVs) play a role in maintaining mitochondrial homeostasis and disposing of oxidized derivatives. These MDVs are enriched in Mito-DAMPs and can contribute to neuroinflammation and neurodegenerative disorders. Therefore, Mito-DAMPs are implicated in the aging process and may have implications for interventions to delay aging and extend lifespan.

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