Does Moderna use RNA or DNA?
Answers from top 10 papers
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| Papers (10) | Insight |
|---|---|
| Metabolic arguments favor the possibility that RNA genomes preceded the use of DNA as the informational macromolecule. | |
| However, RNA, but not DNA, oligonucleotides will be useful for sequence-specific binding of (i) double helical RNA and (ii) RNA. DNA hybrids if the purine Watson-Crick strand is RNA. | |
| Assuming an RNA world, in which RNA preceded the DNA/protein world, at some point in time DNA must have taken over the role as the information storage molecule from RNA. | |
| In addition, the candidate from Moderna is an RNA vaccine, developed using a technology that, compared with traditional vaccines methods, is faster, cheaper, and easier to scale-up. | |
47 Citations | The transition from RNA to DNA thus appears to require intermediate steps, and we suggest that the naturally occurring 2′-O-methylated RNA, with chemical properties intermediate between RNA and DNA, is a suitable candidate. |
| This trend was notably stronger in the context of RNA supporting the idea that dual-use codon optimization and informational multiplexing in DNA resulted from the preadaptation of the RNA duplex to resist changes to thermostability. | |
23 Citations | So, RNA/DNA ratios can be used only on prereproductive, age-synchronized cultures. |
| Considerable evidence suggests that RNA molecules evolved prior to DNA molecules and proteins, and that many processes now involving DNA and proteins were previously accomplished by RNA alone. | |
77 Citations | Either DNA-cellulose or DNA paper can be used preparatively to select intact, specific RNAs that can be used subsequently for translation in vitro as a template for reverse transcriptase, as a source of pure infectious RNA, or for any other experiment in which pure, intact RNA is required. |
612 Citations | The RNA World Hypothesis suggests that prebiotic life revolved around RNA instead of DNA and proteins. |
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