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Does obesity increase a person's risk for metabolic syndrome?

Insulin resistance

Metabolic syndrome

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Journal Article•DOI Ectopic Fat Deposition and the Metabolic Syndrome in Obese Children and Adolescents Anna M. G. Cali, Sonia Caprio - Show less +1 more 21 Jan 2009-Hormone Research in Paediatrics 63 Citations	The prevalence of the metabolic syndrome is high in obese children and adolescents and increases with worsening obesity.
Journal Article•DOI Obesity and the metabolic syndrome in children and adolescents. Ram Weiss, James Dziura, Tania S. Burgert, William V. Tamborlane, Sara E. Taksali, Catherine W. Yeckel, Karin Allen, Melinda Lopes, Mary Savoye, John C. Morrison, Robert S. Sherwin, Sonia Caprio - Show less +11 more 03 Jun 2004-The New England Journal of Medicine 3.2K Citations	The prevalence of the metabolic syndrome is high among obese children and adolescents, and it increases with worsening obesity.
Open access•Journal Article•DOI Risk factors for the metabolic syndrome: the Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985-2001. Mercedes R. Carnethon, Catherine M. Loria, James O. Hill, Stephen Sidney, Peter J. Savage, Kiang Liu - Show less +5 more 01 Nov 2004-Diabetes Care 310 Citations	BMI and weight gain are important risk factors for the metabolic syndrome.
Open access•Journal Article•DOI Risk factors associated with the metabolic syndrome in Cali, Colombia (2013): A case-control study. Sayda Milena Pico, Gustavo Bergonzoli, Adolfo Contreras - Show less +2 more 31 Mar 2019-Biomedica 4 Citations	Obesity was the main risk factor associated with the metabolic syndrome.

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How does metabolic disorders relate to obesity?5 answersMetabolic disorders are closely related to obesity. Obesity is a chronic disease characterized by the excessive accumulation of body fat, and it is commonly associated with metabolic disorders such as type 2 diabetes, cardiovascular diseases, and insulin resistance. In obesity, there is an abnormal production of pro-inflammatory cytokines by immune cells and adipocytes, which contributes to disease progression. Genetic variations or mutations in factors such as SIM-1, osteocalcin, and the JAK/STAT pathway can disrupt metabolic homeostasis and increase the risk of obesity-related complications. Metabolic dysfunction driven by obesity, including hyperglycemia and dyslipidemia, also increases the risk of developing various types of cancer. Overall, metabolic disorders play a significant role in the pathogenesis of obesity and its associated comorbidities, highlighting the importance of managing metabolic dysfunction for preventing and treating obesity-related complications.

How does the presence of metabolic syndrome affect the risk factors?4 answersThe presence of metabolic syndrome increases the risk factors for cardiovascular disease, diabetes, stroke, and mortality. These risk factors include obesity, high blood pressure, hyperglycemia, and dyslipidemia, both in terms of reduced high-density lipoprotein concentrations and elevated triglycerides. Patients with metabolic syndrome have higher waist circumference, waist-to-hip ratio, and body mass index compared to healthy controls. They also exhibit increased lipid parameters, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and microalbuminuria. Metabolic syndrome is associated with hypertension, elevated triglyceride levels, low high-density lipoprotein level, insulin resistance, and central obesity, which increase the risk of heart disease, fatty liver, and multiple cancers. Modifiable risk factors such as exercise and diet play a crucial role in the prevention and control of metabolic syndrome. However, there is limited evidence linking metabolic syndrome to meal timing and frequency. Metabolic syndrome is independently associated with an increased risk of gastrointestinal cancer, including colorectal cancer, hepatocellular carcinoma, pancreatic cancer, and esophageal adenocarcinoma.

What is the association with metabolic syndrome and psychiatric patients?5 answersMetabolic syndrome (MetS) is associated with psychiatric disorders such as severe mental illness (SMI), major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, anxiety disorder, attention-deficit/hyperactivity disorder (ADHD), and posttraumatic stress disorder (PTSD). Psychiatric patients have a higher risk of developing MetS due to factors such as abnormalities in lipid metabolism, glucose homeostasis, obesity, hypertension, unhealthy lifestyle, poor adherence to medical regimen, and the use of specific psychotropic medications. The prevalence of MetS in psychiatric patients is higher compared to the general population, and it is associated with higher adiposity measures, cardiovascular markers, comorbid conditions, and smoking. Screening for metabolic disturbances in psychiatric patients is recommended to identify high-risk individuals and implement preventive measures and lifestyle changes.

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