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Perforin plays a central role in apoptosis induced by granzymes.
Perforin mediates apoptosis in the pathogenesis of the epidermal cell changes in SJS but not in EMH.
In conclusion, accumulation of perforin+ cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.
These results suggest that perforin mediated apoptosis may be associated with the pathophysiology of lung injury and fibrosis.
These data suggest a pivotal role for perforin in triggering epithelial cell apoptosis.
Cells undergoing apoptosis were detected in the CNS of both the perforin (-/-) and control groups, indicating that perforin is not essential for programmed cell death.
Moreover, our studies demonstrated that the anticancer activity of perforin and granzyme B was sustainable in vivo as tumor development by inducing cell apoptosis.
(2) Antigen-dependent neuronal apoptosis may occur independently of perforin and members of the granzyme B cluster (within ∼1 h), suggesting that extracellular effects can substitute for intracellular delivery of granzymes by perforin.
These findings indicated that perforin-induced nuclear accumulation of grB precedes apoptosis, and is not a by-product of caspase-induced nuclear membrane degradation.

Related Questions

What is the role of perforin and granzymes in cancer?5 answersPerforin and granzymes play important roles in cancer. Granzymes are serine proteases that initiate apoptosis in cancer cells through caspase-dependent and caspase-independent pathways. Granzyme B, in particular, has powerful effector properties and is being explored as a potential basis for targeted therapeutic strategies in cancer treatment. Additionally, granzymes are involved in the cytotoxicity reaction of human killer cells, which can lead to the death of cancer cells. Furthermore, granzymes are released by cytotoxic lymphocytes and have been linked to inflammation, suggesting their potential significance in colorectal cancer pathogenesis. Perforin, on the other hand, is an essential component of cytotoxic granules and is involved in the cytotoxicity of T lymphocytes and natural killer cells. Overall, perforin and granzymes have been found to play crucial roles in cancer cell death and immune responses against cancer.
How does fas receptor induce cell death?3 answersThe Fas receptor induces cell death through various mechanisms. One mechanism involves the activation of caspases, which are enzymes that play a key role in apoptosis. When Fas is engaged by its ligand, FasL, caspase enzymatic activity is triggered, leading to the proteolytic cleavage of gasdermin family members, such as GSDMD and GSDME, which are hallmarks of pyroptosis. Another mechanism involves the regulation of endolysosomal trafficking. The endosome associated trafficking regulator 1 (ENTR1) controls the cell surface levels of Fas by regulating its delivery from endosomes to lysosomes. This process is important for the termination of Fas signal transduction. Additionally, the interaction between Fas-ligand and caveolin-1, the main protein component of rafts, plays a role in the translocation of Fas-ligand to rafts, where it can induce cell death. The Fas death receptor is also required for cell death induced by leukotoxin (LtxA), a virulence factor secreted by the oral bacterium Aggregatibacter actinomycetemcomitans. Overall, Fas receptor-induced cell death involves caspase activation, regulation of endolysosomal trafficking, and interaction with other proteins and molecules.
Do neurotrophins induce apoptosis?10 answers
How to induce apoptosis in fat cells?10 answers
Is Ras pro apoptotic?9 answers
What enzymes trigger apoptosis?10 answers

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