Does perforin induce apoptosis?
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23 Citations | Perforin plays a central role in apoptosis induced by granzymes. |
73 Citations | Perforin mediates apoptosis in the pathogenesis of the epidermal cell changes in SJS but not in EMH. |
31 Citations | In conclusion, accumulation of perforin+ cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes. |
These results suggest that perforin mediated apoptosis may be associated with the pathophysiology of lung injury and fibrosis. | |
53 Citations | These data suggest a pivotal role for perforin in triggering epithelial cell apoptosis. |
142 Citations | Cells undergoing apoptosis were detected in the CNS of both the perforin (-/-) and control groups, indicating that perforin is not essential for programmed cell death. |
Open access•Journal Article 9 Citations | Moreover, our studies demonstrated that the anticancer activity of perforin and granzyme B was sustainable in vivo as tumor development by inducing cell apoptosis. |
(2) Antigen-dependent neuronal apoptosis may occur independently of perforin and members of the granzyme B cluster (within ∼1 h), suggesting that extracellular effects can substitute for intracellular delivery of granzymes by perforin. | |
CD8+ T cells from the VAT of Prf1null mice have increased proliferation and impaired early apoptosis, suggesting a role for perforin in the regulation of T-cell turnover during HFD feeding. | |
73 Citations | These findings indicated that perforin-induced nuclear accumulation of grB precedes apoptosis, and is not a by-product of caspase-induced nuclear membrane degradation. |
Related Questions
What is the role of perforin and granzymes in cancer?5 answersPerforin and granzymes play important roles in cancer. Granzymes are serine proteases that initiate apoptosis in cancer cells through caspase-dependent and caspase-independent pathways. Granzyme B, in particular, has powerful effector properties and is being explored as a potential basis for targeted therapeutic strategies in cancer treatment. Additionally, granzymes are involved in the cytotoxicity reaction of human killer cells, which can lead to the death of cancer cells. Furthermore, granzymes are released by cytotoxic lymphocytes and have been linked to inflammation, suggesting their potential significance in colorectal cancer pathogenesis. Perforin, on the other hand, is an essential component of cytotoxic granules and is involved in the cytotoxicity of T lymphocytes and natural killer cells. Overall, perforin and granzymes have been found to play crucial roles in cancer cell death and immune responses against cancer.
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