scispace - formally typeset
Search or ask a question

Answers from top 4 papers

More filters
Papers (4)Insight
Evidence is also presented that the central nervous system effects of psilocybin are exerted only after its transformation to the 4-hydroxy analog, psilocin.
These experiments indicate that possibly in the intact animal psilocybin is rapidly dephosphorylated and is pharmacologically active as psilocin, while the duration of the effect might be controlled by the oxidation of the latter compound to an o-quinone type of structure.
Our findings provide further evidence for the rapid plasticity-promoting effects of psilocybin.
The results of this study demonstrate the rapid dephosphorylation of psilocybin by the intact mouse.

Related Questions

What psilocybin parkinson?4 answersPsilocybin is a natural hallucinogenic substance found in certain species of mushrooms. It has been studied for its potential therapeutic effects in various mental health disorders. In the context of Parkinson's disease (PD), research has shown that visual hallucinations (VH) are common in PD patients and can significantly impact their quality of life. The development of VH in PD has been associated with atrophy of the pedunculopontine nucleus (PPN) and its thalamic target area, suggesting a role for the cholinergic system in VH pathophysiology. Additionally, there is ongoing research on the potential use of psilocybin derivatives in the treatment of PD symptoms. Preliminary evidence suggests that these derivatives may have anti-inflammatory, neuroprotective, and immunomodulatory effects in the nervous system. However, more studies are needed to determine their efficacy and influence on the neurodegenerative progression of PD.
Do psychedelics induce neurogenesis?4 answersPsychedelics have been shown to induce neurogenesis. Studies have demonstrated that psychedelics such as ayahuasca, DMT, psilocybin, and LSD can stimulate the birth of new neurons in the hippocampus, a region of the brain involved in memory and learning. These substances have been found to promote the proliferation of neural stem/progenitor cells and their differentiation into mature neurons, as well as the formation of new synaptic connections. The mechanisms underlying this neurogenesis involve the activation of molecular pathways such as TrkB, mTOR, and 5-HT2A signaling. Furthermore, psychedelics have been shown to increase the expression of plasticity-related genes and proteins, including Brain-Derived Neurotrophic Factor (BDNF), which is associated with neuroplasticity. Overall, the evidence suggests that psychedelics can induce neurogenesis and promote neural plasticity, which may contribute to their therapeutic potential in treating psychiatric and neurodegenerative disorders.
Can psilocybin create new neurons?3 answers
Does psilocybin create neurons?10 answers
Does psilocybin create new neurons?4 answers
Does psilocybin grow neurons?7 answers

See what other people are reading

Whant is the function of aquaporins?
5 answers
Aquaporins (AQPs) primarily facilitate water transport across cell membranes. However, their functions extend beyond water transport. AQPs are involved in transporting various small molecules like glycerol, urea, gases (CO2, NO, etc.), ions, and even silicon and arsenite. Additionally, AQPs play roles in unexpected functions such as tumor angiogenesis regulation, cell migration promotion, skin hydration regulation, neural signal transduction, cell proliferation, inflammation modulation, and organelle physiology. In the central nervous system, AQPs mediate water flux and are crucial in brain disorders like cerebral edema and neurodegenerative disorders. In the lungs, AQPs (AQP1, AQP2, AQP4, AQP5) are essential for fluid balance in respiratory processes. Overall, AQPs are vital in various physiological processes beyond simple water transport.
What is the role of TNF alpha on beta thalassemia?
4 answers
TNF-alpha plays a significant role in beta thalassemia by influencing various aspects of the disease. Studies have shown that TNF-alpha gene polymorphisms are associated with differences in Vitamin D, Calcium, ALP, and ferritin levels in beta thalassemia patients. Additionally, TNF-alpha has been linked to ineffective erythropoiesis in thalassemic patients, affecting erythropoietin (EPO) and erythropoietin receptor (EPOR) expression, leading to reduced cell proliferation and increased apoptosis in erythroid progenitor cells. Elevated TNF-alpha levels in beta thalassemia patients have been observed, potentially contributing to complications like anemia and immune-mediated issues, with changes in TNF concentrations post-bone marrow transplantation correlating with immune complications.
How does ivermectin stimulate nerve regeneration?
5 answers
Ivermectin stimulates nerve regeneration through various mechanisms. Studies have shown that ivermectin promotes peripheral nerve repair by inducing fibroblasts to adopt a glia-like phenotype, leading to enhanced proliferation and migration of neural stem cells. Additionally, isoquercitrin, a compound with anti-oxidative properties, has been found to promote nerve regeneration and remyelination, increase the expression of nerve regeneration markers, and inhibit oxidative stress, ultimately aiding in motor functional recovery after peripheral nerve injury. Furthermore, experiments with planaria species revealed that exposure to ivermectin during regeneration resulted in patterning abnormalities and delayed regeneration, highlighting the impact of ion channel drugs like ivermectin on regenerative processes. These findings collectively demonstrate the multifaceted role of ivermectin in stimulating nerve regeneration through various cellular and molecular pathways.
Citation for this?
5 answers
The citation for the question can be found in the abstract by Alfonso Iorio et al, which discusses the lack of randomized controlled trial (RCT)-based evidence in the field of haemophilia treatment, particularly regarding prophylactic clotting factor concentrates. The authors highlight the limited number of trials and patients studied, emphasizing the need for well-designed RCTs to assess the effectiveness of prophylactic clotting factor concentrates in hemophilia patients. This paper prompts a debate on the necessity and ethics of conducting RCTs in the haemophilia field, drawing parallels to a popular BMJ paper on the lack of evidence for parachutes when jumping from airplanes.
Is assisted therapy with psychedelic efficace?
5 answers
Assisted therapy with psychedelics has shown promising efficacy in treating various mental health conditions. Studies have demonstrated positive outcomes in managing treatment-resistant cases, personality disorders, PTSD, major depression, and substance use disorders. Psychedelic agents like psilocybin, ayahuasca, LSD, and MDMA have been found to produce rapid and enduring improvements in anxiety, depression, and PTSD symptoms, with multiple dosing sessions showing greater efficacy. Additionally, psilocybin-assisted therapy has shown benefits in reducing heavy drinking days and promoting smoking abstinence in patients with substance use disorders. The use of psychedelic substances presents a novel approach that may offer significant advantages in the treatment of mental health conditions, warranting further research and exploration in this field.
Is assisted therapy with psilocybin efficace?
5 answers
Assisted therapy with psilocybin has shown promising efficacy in treating various mental health conditions. Studies have demonstrated that psilocybin-assisted psychotherapy (PAP) can be effective in managing treatment-resistant depression, especially in cases of difficult-to-treat depression and depression in cancer patients. The use of psilocybin coupled with group therapy has shown significant improvements in depressive symptoms, with high response and remission rates observed. Additionally, PAP has been found to be cost-effective compared to conventional medication and cognitive behavioral therapy for severe depression, further supporting its efficacy. Combining psilocybin with psychological support has shown long-term effectiveness in reducing depression and anxiety severity, indicating its potential as a valuable therapeutic option.
How do NSC-EVs know where to travel to the site of neural injury?
4 answers
Neural stem cells (NSCs) and their extracellular vesicles (NSC-EVs) possess the ability to migrate towards sites of neural injury through various mechanisms. NSCs exhibit directed migration in response to electric fields (EFs), while NSC-EVs can be guided by chemotaxis towards tumor sites. The inflammatory response in injured areas, characterized by factors like SDF-1α, plays a crucial role in attracting NSCs towards the site of injury. Additionally, the presence of specific receptors like CXCR4 on NSCs enables them to respond to chemotactic signals and migrate towards areas expressing these signals. Understanding these mechanisms of migration and homing of NSCs and NSC-EVs to sites of neural injury is essential for developing effective therapeutic strategies for CNS repair and brain tumor treatment.
Does silocyban help depression?
5 answers
Psilocybin, a psychedelic compound, has shown promising results in alleviating depression. Studies have demonstrated that psilocybin, when administered in conjunction with therapy, led to significant improvements in depressive symptoms in cancer patients over extended periods, with high response rates and remission levels. On the other hand, Silexan, derived from Lavandula angustifolia, has exhibited anxiolytic effects and has also shown efficacy in reducing depressive symptoms in patients with anxiety disorders. Both psilocybin and Silexan have been found to have antidepressant properties, with psilocybin showing effectiveness in cancer patients and Silexan demonstrating benefits in individuals with anxiety disorders. Further research is needed to explore the full potential and mechanisms of action of these compounds in treating depression.
What is Aquaporins and functional?
5 answers
Aquaporins (AQPs) are integral membrane proteins that regulate water flow across cell membranes. They are crucial for various physiological functions, including hydration, wound healing, immune responses, and cell volume regulation. AQPs also facilitate the transport of small molecules like glycerol, urea, gases, ions, and other substances across membranes. In the central nervous system, AQPs play a vital role in water flux between different compartments and are implicated in brain disorders like cerebral edema. Additionally, AQPs are involved in skin hydration, barrier function, and protection against environmental stresses in the skin. The diverse functions of AQPs highlight their significance in maintaining cellular homeostasis and contributing to various physiological processes in different organs and tissues.
What is the role of obstetric ultrasound in detecting and managing fetal anomalies?
5 answers
Obstetric ultrasound plays a crucial role in detecting and managing fetal anomalies by enabling early diagnosis and informed decision-making. High-resolution ultrasound scans, especially in the second trimester, have shown good detection rates for anomalies, aiding in reducing perinatal and maternal morbidity. Early detection allows for timely medical terminations, planning deliveries in well-equipped centers, and providing in utero therapy when necessary. The use of both first and second trimester ultrasound scans enhances anomaly detection, particularly for major congenital abnormalities associated with chromosomal and genetic issues. Early diagnosis through screening programs, especially in high-risk populations, leads to better outcomes, clinical decision-making on delivery modes, and management of pregnancies with lethal anomalies.
Why dopant elements are used in the production of bioglass?
8 answers
Dopant elements are used in the production of bioglass to enhance its properties and functionality for medical applications, addressing specific clinical needs. The incorporation of dopant elements into bioglass compositions is a strategic approach to improve their performance in biological environments, aiming to optimize their interaction with biological tissues and to introduce additional beneficial properties. One of the primary reasons for doping bioglass is to improve its bioactivity and to tailor its interaction with body fluids, thereby enhancing its ability to bond with bone and other tissues. For instance, the addition of elements like zinc and magnesium has been shown to not only add antibacterial function but also to increase positive effects on bone metabolism, which is crucial for applications in orthodontic implants and bone repair. Similarly, the doping of calcium into bioactive glass nanoparticles has been demonstrated to achieve better bioactivity, which is essential for bone repairs. Moreover, dopant elements are used to introduce specific therapeutic properties. For example, strontium and cobalt ions have been doped into bioglass to produce polymeric scaffolds for tissue engineering, showing promising results in terms of cell viability and bone tissue engineering applications. Additionally, titanium ions have been added to improve mechanical strength, antibacterial ability, and stability of bioactive glass, further optimizing it for medical use. Dopant elements also play a significant role in enhancing the structural and mechanical properties of bioglass. For instance, the doping with zirconium(IV) and tantalum(V) oxides has been found to alter the physical and chemical properties of Bioglass 45S5, making it more suitable for restoring bone tissue and treating malignant neoplasms. Furthermore, the use of Eu3+ ions as a spectroscopic probe has enabled the measurement of changes in glass structure, leading to the development of bioactive glass-ceramics with increased mechanical properties. In summary, dopant elements are crucial in the production of bioglass as they enhance bioactivity, introduce therapeutic properties, and improve structural and mechanical characteristics, making bioglass more effective for a wide range of medical applications.