Does rapamycin increase angiogenesis?
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364 Citations | Thus, signaling via mTOR may represent a novel mechanism whereby hypoxia augments mitogenstimulated vascular cell proliferation and angiogenesis.—Humar, R., Kiefer, F. N., Berns, H., Resink, T. J., Battegay, E. J. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) ‐dependent signaling. |
430 Citations | Akt signaling in the tumor vascular stroma was sensitive to rapamycin, suggesting that rapamycin may affect tumor growth in part by acting as a vascular Akt inhibitor. |
14 Citations | Experimental data suggest that rapamycin may reduce angiogenesis and tumour growth by inhibiting the vascular endothelial growth factor (VEGF) pathway. |
242 Citations | Rapamycin appears to inhibit tumor growth by halting tumor cell proliferation, inducing tumor cell apoptosis, and suppressing tumor angiogenesis. |
364 Citations | Here we show that mammalian target of rapamycin (mTOR) signaling plays a key role in hypoxia‐triggered smooth muscle and endothelial proliferation and angiogenesis in vitro. |
102 Citations | —Rapamycin potently inhibited early and mid stages of VEGF-A164–driven angiogenesis, but not late-stage angiogenesis or lymphangiogenesis. |
56 Citations | Rapamycin combines antiproliferative and antiinflammatory properties and reduces neointima formation after angioplasty in patients. |
223 Citations | Moreover, in vitro experiments showed that CsA promotes angiogenesis by a transforming growth factor-β–related mechanism, and that this effect is abrogated by rapamycin. |
In conclusion, rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by blocking the mTOR signal pathway and subsequently downregulating the expression of VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3. | |
According to our data rapamycin might have an anti-angiogenesis effect via inhibition of VEGF expression. |
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