Search or ask a question

Does superoxide dismutase contain heme?

Isoelectric point

Hydrogen peroxide

Superoxide dismutase

Answers from top 6 papers

PDF

Open Access

More filters

Papers (6)	Insight
Open access•Journal Article•DOI Purification of an inhibitor of erythroid progenitor cell cycling and antagonist to interleukin 3 from mouse marrow cell supernatants and its identification as cytosolic superoxide dismutase. Fred G. Pluthero, Mona M. Shreeve, Denise Eskinazi, H. Van Der Gaag, Kuo-Sen Huang, J. D. Hulmes, M. Blum, Arthur A. Axelrad - Show less +7 more 01 Sep 1990-Journal of Cell Biology 22 Citations	These observations show that superoxide dismutase is able to affect the cycling and growth factor responses of hematopoietic cells, activities that have not previously been associated with this enzyme.
Open access•Journal Article•DOI A Novel Heme Protein, the Cu,Zn-Superoxide Dismutase from Haemophilus ducreyi Francesca Pacello, Paul R. Langford, J. Simon Kroll, Giulietta Smulevich, Alessandro Desideri, Giuseppe Rotilio, Andrea Battistoni - Show less +6 more 10 Aug 2001-Journal of Biological Chemistry 31 Citations	The introduction of a histidine residue in the corresponding position of the Cu,Zn-superoxide dismutase fromHaemophilus parainfluenzae was not sufficient to confer the ability to bind heme, indicating that other residues neighboring His-64 are involved in the formation of the heme-binding pocket.
Journal Article•DOI Effect of Aluminium on Superoxide Dismutase Ruth Shainkin-Kestenbaum, Andrew J. Adler, Geoffrey M. Berlyne, C. Caruso - Show less +3 more 01 Nov 1989-Clinical Science 21 Citations	Thus, the protective role of superoxide dismutase is particularly important.
Open access•Journal Article•DOI The iron-containing superoxide dismutase of Ralstonia metallidurans CH34. Murielle Roux, Jacques Covès - Show less +1 more 23 Apr 2002-Fems Microbiology Letters 19 Citations	This Fe-SOD seems to be the only active superoxide dismutase expressed in R. metallidurans CH34.
Journal Article•DOI Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation Joseph P. Martin, Michael Dailey, Elliott Sugarman - Show less +2 more 01 Jun 1987-Archives of Biochemistry and Biophysics 302 Citations	These observations form the basis for negative and positive assays of superoxide dismutase which are inexpensive and simple to perform.
Journal Article•DOI Biological protection by superoxide dismutase F. Lavelle, A.M. Michelson, L. Dimitrijevic - Show less +2 more 16 Nov 1973-Biochemical and Biophysical Research Communications 168 Citations	The results demonstrate the biological role and importance of superoxide dismutase.

My columns

Related Questions

What are the conserved sequences of Superoxide dismutase protein in plant?5 answersConserved sequences of Superoxide dismutase (SOD) proteins in plants include signature Cu/Zn-SOD motifs, conserved Cu/Zn-binding residues, and cysteines forming disulfide bonds. These conserved features are crucial for the antioxidant function of SODs. Additionally, plant Cu/Zn-SODs exhibit variations in subcellular localization, with shifts from chloroplasts to cytosol or peroxisomes, indicating functional divergence over evolutionary time. Furthermore, the SOD gene family in plants has undergone segmental duplications, leading to the presence of multiple gene copies with distinct characteristics and expression patterns in response to various stresses. These conserved sequences and structural features highlight the importance of SODs in plant antioxidant defense mechanisms and stress responses.

What is the effect of heme oxygenase on mitochondria?4 answersHeme oxygenase (HO) has various effects on mitochondria. HO-1, an isoform of HO, plays a critical role in defending the lung against oxidative stress and inflammation by protecting against mitochondria dysfunction and restoring mitophagy. HO-2, another isoform of HO, is involved in oxygen sensing and regulates mitochondrial oxygen consumption and reactive oxygen species (ROS) production. Bilirubin, a byproduct of heme degradation by HO, affects vital functions of hepatocytes, including mitochondria and the endoplasmic reticulum (ER), and induces ER stress, compromising cellular metabolism and proliferation. Induced expression of HO-1 can result in the translocation of HO-1 protein to mitochondria, leading to mitochondrial dysfunction and increased ROS production. However, mitochondria-targeted HO-1 can be cytoprotective under acute pathological conditions, protecting against hypoxia-dependent cell death and loss of mitochondrial membrane potential.

What role does superoxide dismutase play in alcohol metabolism?5 answersSuperoxide dismutase (SOD) plays a crucial role in alcohol metabolism. Chronic ethanol consumption leads to oxidative stress, which contributes to alcoholic liver disease (ALD). SOD2, a mitochondrial antioxidant enzyme, is affected by ethanol metabolism. Ethanol increases the acetylation of SOD2 at specific lysine sites, resulting in decreased enzyme activity. SOD protects biomolecules against damage from superoxide radicals (O2-). Loss of SOD activity can lead to defects in amino acid metabolism and increased oxidative damage to DNA. SOD also prevents the oxidation of iron-sulfur clusters, which can inactivate key enzymes involved in metabolism. Additionally, SOD1, another form of SOD, has effects beyond its superoxide dismutase activity and is involved in redox regulation of metabolism. Therefore, SOD plays a critical role in maintaining redox homeostasis and protecting against oxidative damage in alcohol metabolism.

Are antioxidants used as markers of ROS?2 answersAntioxidants are used as markers of reactive oxygen species (ROS) in various contexts. In the study of small domestic ruminants, quantification of ROS and enzymatic antioxidant activity in erythrocytes and spermatozoa can be used as biomarkers of oxidative stress. Similarly, in the investigation of antibacterial substances, the production of intracellular ROS was measured to understand the mechanism of antibiotic-mediated death. In the analysis of Darjeeling tea clones, total phenols, flavonoids, and antioxidative enzymes were estimated to determine antioxidant activity. In plants, antioxidants play a crucial role in defense against oxidative stress caused by salt stress, and their levels can be altered to improve salt tolerance. Furthermore, in the field of plant biology, measuring ROS and other indicators of redox imbalance is important for understanding ROS-mediated signaling and damage, especially in the context of developing stress-tolerant crops.

Do Microaerophiles have superoxide dismutase?7 answers

Does superoxide dismutase contain iron?6 answers

See what other people are reading

Does tea help with recovery from cold?

Tea can aid in the recovery from cold by leveraging its diverse medicinal properties. Various types of tea, such as healthcare tea, traditional Chinese medicine tea, and cold-preventing tea, contain ingredients like licorice, mint, ginger, and honeysuckle, which possess anti-inflammatory, immune-boosting, and symptom-relieving effects. These teas can help dispel wind cold, relieve fever, clear away heat, and enhance immunity, thereby alleviating cold symptoms like headache, cough, and nasal congestion. Additionally, phytohormones like abscisic acid play a crucial role in the cold response and recovery of tea leaves, indicating the potential of tea in combating cold-related issues. Therefore, incorporating tea into one's routine during a cold can potentially aid in a quicker recovery and alleviate discomfort associated with the illness.How fast is IL-12Receptor produced after IL-12 stimuli?

IL-12 receptor production occurs rapidly after IL-12 stimulation. Studies have shown that IL-12 induces the up-regulation of IL-12 receptor subunits on human primary microglial cells within a short timeframe, leading to functional IL-12 receptor expression. Additionally, the binding kinetics of IL-12 to PHA-activated lymphoblasts indicate a rapid process, with equilibrium reached within 60 minutes, suggesting swift receptor interactions. This rapid response is crucial for the downstream signaling events triggered by IL-12, such as tyrosine phosphorylation, nuclear translocation of STAT4, and induction of IL-12p40 mRNA expression. Therefore, the production and activation of IL-12 receptors following IL-12 stimuli are swift processes essential for mediating the biological effects of IL-12 on target cells.How does the bleaching process affect the surface area of fibers in textiles?

The bleaching process in textiles has a significant impact on the surface area of fibers. Studies have shown that bleaching with chemicals like Hydrogen Peroxide can lead to a reduction in surface lignin content, resulting in increased brightness and improved color stability. Additionally, bleaching induces surface oxidation, causing a decrease in the amount of lignin on the fiber surface and the formation of new aliphatic carbons, which can deposit on the fiber surface and affect bleaching efficiency. Furthermore, the bleaching method involving a combination of refining and bleaching liquids can ensure uniform adsorption of whitening agents on the textile material's surface, leading to improved quality and reduced production costs. Overall, bleaching plays a crucial role in altering the surface chemistry of fibers in textiles, impacting their mechanical and optical properties.Why antioxidants are so important and what is the balance between oxidation and reduction reactions?

Antioxidants play a crucial role in preventing oxidative stress and protecting cells from damage caused by free radicals, which are implicated in various diseases. The balance between oxidation and reduction reactions is essential for maintaining redox homeostasis in the body. When there is an excess of oxidants or a deficiency in the antioxidant system, oxidative stress occurs, leading to high levels of reactive species and contributing to the development of degenerative diseases. Antioxidants act by neutralizing free radicals, terminating chain reactions, and preventing oxidative damage to cells and tissues. This balance is critical for overall health and wellbeing, as it helps in maintaining the proper functioning of cells and tissues while protecting against the harmful effects of oxidative stress.WHAT OTHER chromogenic reagent USED INSPITE OF TOOS 1-Propanesulfonic acid, 3-[ethyl(3-methylphenyl)amino]-2-hydroxy-, sodium salt?

A variety of chromogenic reagents are utilized in addition to TOOS (1-Propanesulfonic acid, 3-[ethyl(3-methylphenyl)amino]-2-hydroxy-, sodium salt). These include a newly synthesized water-soluble phenylenediamine derivative for colorimetric determination of hydrogen peroxide, a chromogenic reagent involving ammonium molybdate and ascorbic acid or turmeric for reaction with a flame retardant, and a proposed spectrophotometric reagent, Mordant blue-9, for the sensitive determination of trace amounts of iron III without the need for complex separation procedures. Additionally, immobilization of chromogenic reagents on solid phase micro-beads via sulfonation reaction has been demonstrated for applications like lab-on-valve bead injection spectroscopy. These diverse chromogenic reagents offer alternatives for various analytical and detection purposes beyond TOOS.What the difference of ROS and radicals?

Reactive oxygen species (ROS) encompass a variety of oxygen-based radicals and non-radicals, produced in living organisms during aerobic activities. Free radicals, including ROS, are highly reactive molecules with unpaired electrons, causing them to interact with biomolecules like proteins and lipids. ROS are crucial in redox-sensitive signaling pathways and immune responses, while excessive ROS levels can lead to cellular damage. Under physiological conditions, ROS act as signaling molecules, contributing to various cellular processes like differentiation and apoptosis. While ROS are a subset of radicals, the term "radicals" is broader, encompassing molecules with unpaired electrons beyond just oxygen-based ones like ROS. In summary, ROS are a specific type of radical that plays essential roles in cellular signaling and oxidative stress, while radicals, in general, include a wider array of highly reactive molecules with unpaired electrons.When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence?

Anaerobes face oxygen toxicity due to reactive oxygen species (ROS) like superoxide and hydrogen peroxide. Despite possessing similar defences to aerobes, anaerobes are vulnerable to oxygen due to their reliance on enzymes reactive with oxidants. Anaerobic ammonium oxidation (anammox) bacteria exhibit varying oxygen sensitivities, with marine species showing higher oxygen tolerance and detoxification mechanisms than freshwater species. Sulfate-reducing bacteria (SRB) have developed complex systems to combat O2 toxicity, including unique enzymes like superoxide reductase and peroxidases. Strict anaerobes, including clostridia and methanogenic archaea, exhibit varying oxygen resistance, with physiological and enzymatic mechanisms aiding in aerotolerance. Overall, anaerobes employ diverse strategies to cope with oxygen exposure, highlighting the intricate balance between oxygen toxicity, tolerance, and defence mechanisms in anaerobic microorganisms.What are the specific molecular mechanisms by which ROS induce DNA damage and mutations in cancer cells?

Reactive oxygen species (ROS) induce DNA damage and mutations in cancer cells through various molecular mechanisms. ROS, such as O atoms, OH radicals, and H2O2, react with DNA molecules, breaking essential chemical bonds and causing irreversible damage. This damage affects gene transcription, replication, and reproduction of cancer cells, inhibiting their proliferation. Elevated ROS levels in cancer cells lead to oxidative stress, resulting in genomic instability, altered gene expression, and cellular transformation to tumor cells or cancer stem cells (CSCs). The interaction between ROS and DNA can generate pro-mutagenic lesions, contributing to mutations necessary for cancer development. Additionally, ROS overactivation in cancer cells promotes tumorigenic signaling events by inducing oncogenic mutations and enhancing metabolism.How can byproduct bovine blood be used?

Byproduct bovine blood can be utilized in various ways to add value and reduce waste in the meat industry. One approach involves enzymatic hydrolysis of bovine blood to produce protein hydrolysates suitable for microbial growth media, showing comparable results to commercial peptones in supporting bacterial growth. Additionally, the transformation of livestock blood proteins and peptides can yield antioxidants, stabilizers, and biomarkers for the food industry, as well as functional components for pharmaceutical applications, highlighting the potential for valorization in these sectors. Furthermore, the enzymatic hydrolysis of serum albumin using pepsin can generate bioactive peptides, with optimal separation achieved using polyethersulfone membranes at specific pH values, offering a method to obtain purified fractions rich in bioactive peptides from serum albumin. Overall, these strategies demonstrate the diverse applications of byproduct bovine blood in creating high-value products and reducing environmental impact.What specific benefits does CIO2 have on various health conditions?

CIO2, specifically chlorine dioxide, offers various health benefits across different conditions. In wastewater treatment, CIO2 aids in inactivating estrogenic compounds, enhancing the purification process. Cerium oxide nanoparticles (CeO2) demonstrate antioxidant properties, protecting against oxidative stress induced by cigarette smoke, potentially mitigating smoking-related diseases. CeO2 nanoparticles also show promise in alleviating oxidative damage in osteoporosis by reducing reactive oxygen species, enhancing antioxidant enzyme levels, and decreasing cell apoptosis, suggesting therapeutic potential for ROS-related diseases. Additionally, IDO2, a relative of IDO1, plays a role in immune modulation and tolerance, impacting responses to autoantigens and influencing immune tolerance in humans, particularly in conditions like brain cancer and adaptive immune responses.What is the relationship between oxidative stress and obesity in the development of type 2 diabetes (T2DM)?

The relationship between oxidative stress and obesity in the development of type 2 diabetes mellitus (T2DM) is multifaceted and significant. Oxidative stress (OS) arises from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defense mechanisms, leading to cellular and tissue damage. Obesity exacerbates this imbalance by increasing ROS production and diminishing antioxidant defenses, thereby contributing to the pathogenesis of T2DM. Obesity, characterized by excessive fat accumulation, particularly in the visceral region, predisposes individuals to metabolic and cardiovascular diseases by inducing systemic oxidative stress through various biochemical mechanisms. This oxidative stress is a critical link in the development of insulin resistance, a hallmark of T2DM, by activating inflammatory pathways and impairing insulin signaling. The adipose tissue in obesity acts as a significant source of ROS, further perpetuating oxidative stress and inflammation, which are pivotal in the progression from obesity to T2DM. Moreover, the pediatric population is not spared, with increasing rates of obesity leading to a rise in insulin resistance, prediabetes, and T2DM among children. This trend underscores the importance of understanding the factors contributing to oxidative stress and T2DM risk from an early age. Exercise and dietary modifications have been shown to mitigate oxidative stress and improve the redox state, thereby reducing the risk of endothelial dysfunction and inflammation associated with obesity and T2DM. Additionally, understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can lead to novel strategies for reducing the burden of T2DM. In summary, oxidative stress serves as a critical bridge between obesity and the development of T2DM, with both conditions exacerbating each other in a vicious cycle that promotes insulin resistance and metabolic dysfunction.