Does weed affect androgen receptors?
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| Papers (10) | Insight |
|---|---|
25 Citations | The results using flutamide, finasteride, cycloheximide, and actinomycin D indicate that androgen-induced potentiation is dependent on androgen receptors, requires reduction of testosterone to DHT, and occurs independently of transcriptional and translational events. |
61 Citations | In all four brain areas binding of T to androgen receptors was significantly decreased in the presence of ATD, suggesting that ATD may act both as an androgen receptor blocker and as an aromatization inhibitor. |
18 Citations | Potential atheroprotective effects of testosterone could be secondary to (aromatase-mediated) conversion into oestradiol or, alternatively, to direct activation of androgen receptors (AR). |
| The comparable responses to testosterone and the non-aromatizable androgen DHT, coupled with the lack of response to estradiol, suggest that testosterone acts directly on hippocampal androgen receptors rather than indirectly via local estrogen biosynthesis. | |
121 Citations | Androgen receptors in axons located in the cerebral cortex and amygdala and originating in the hippocampus may play an important role in the rapid behavioral effects of androgens. |
61 Citations | Thus, an alternative explanation for the inhibitory effects of ATD on male sexual behavior is that ATD prevents T from binding to androgen receptors. |
| High concentration of androgen receptors in fundamental centers of learning and memory in brain such as hippocampus shows that there may be some relationships between androgen receptors and cognitive aspects of brain. | |
28 Citations | The results suggest that androgen, not estrogen, regulates the differentiation of MPOA opiate receptors. |
40 Citations | Furthermore, androgen self-administration may be mediated by plasma membrane receptors. |
64 Citations | The subcutaneous injection of AAS compounds increased the concentrations of occupied nuclear androgen receptors in the brain, but the magnitude of effect was not related to their potency for inducing aromatase or their relative binding affinity for the androgen receptor suggesting that androgen receptor occupancy in POA is not correlated with the action of androgen on aromatase. |
Related Questions
Is there research on the effects of psychedelics on androgen levels?5 answersResearch has been conducted on the effects of psychedelics on androgen levels. A study by Herrmann and Beach found evidence that androgens have psychotropic properties similar to well-known psychotropic substances, based on clinical observations and experimental work. Another study by Kaiser et al. investigated the effects of mesterolone, an androgen, on psychovegetative symptomatology in aging males. They observed therapeutic changes under mesterolone application, which can be regarded as psychotropic effects. Additionally, a computational molecular dynamic simulation study by Mobisson et al. examined the impact of tetrahydrocannabinol (THC) and cannabidiol (CBD) on the human androgen receptor (AR). The results suggested that THC and CBD have binding affinity to the AR, indicating a potential inhibition of reproductive function. While there is limited research specifically on psychedelics and androgen levels, these studies provide insights into the psychotropic effects of androgens and their potential impact on reproductive function.
Does smoking marijuana have any effect on muscle hypertrophy?5 answersSmoking marijuana does not have any direct effect on muscle hypertrophy. There is no specific mention of marijuana in the abstracts provided. However, one abstract discusses the effect of smoking on skeletal muscle protein metabolism, stating that smoking depresses the rate of skeletal muscle protein synthesis. Another abstract analyzes the adaptations of skeletal musculature to the interaction between physical activity and cigarette smoke exposure, but does not mention marijuana. Therefore, based on the information available, there is no evidence to suggest that smoking marijuana has any direct impact on muscle hypertrophy.
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