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How can you reverse insulin resistance and metabolic syndrome naturally?

Diabetes mellitus

Insulin resistance

Metabolic syndrome

Hyperinsulinemia

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Papers (16)	Insight
Journal Article•DOI Cellular mechanisms of insulin resistance in humans Gerald I. Shulman 08 Jul 1999-American Journal of Cardiology 177 Citations	These cellular mechanisms of insulin resistance can be addressed through combination therapy with agents that reverse the principal pathophysiologic defects of type 2 diabetes.
Journal Article•DOI Alternative and Complementary Treatments for Metabolic Syndrome Mariya Power, Richard E. Pratley - Show less +1 more 19 Feb 2011-Current Diabetes Reports	These interventions may attenuate insulin resistance and reduce the cardiovascular risk factors that together comprise the metabolic syndrome.
Journal Article•DOI Pharmacological approach in the treatment of insulin resistance. B. Vialettes, P. Silvestre - Show less +1 more 01 Jan 1992-Hormone Research in Paediatrics	Finally, blockade of FFA oxidation by specific inhibitors (methylpalmoxyrate) can limit insulin resistance.
Journal Article•DOI Macronutrients and Insulin Resistance in Cholesterol Gallstone Disease Chung-Jyi Tsai, Michael F. Leitzmann, Walter C. Willett, Edward Giovannucci - Show less +3 more 03 Oct 2008-The American Journal of Gastroenterology 47 Citations	Insulin resistance syndrome can be modified by environmental factors, including dietary factors.
Journal Article•DOI Regulation of Insulin Action by Diet and Exercise Stacy L. Schmidt, Matthew S. Hickey - Show less +1 more 01 May 2009-Journal of Equine Veterinary Science	Importantly, both diet and exercise can regulate insulin action and can thus be leveraged as treatment tools to prevent and treat the metabolic syndrome.
Journal Article•DOI Treatment of insulin resistance in diabetes mellitus. Harold E. Lebovitz, Mary Ann Banerji - Show less +1 more 19 Apr 2004-European Journal of Pharmacology 84 Citations	Treatment of insulin resistance and its associated abnormalities can be achieved by lifestyle modification which results in weight loss, by drugs that reverse the abnormal adipocyte effects, by drugs that improve insulin sensitivity at the level of the liver and by anti-inflammatory agents that block activation of the nuclear factor kappa B cascade.
Journal Article•DOI Insulin resistance in PCOS Evanthia Diamanti-Kandarakis 01 Aug 2006-Endocrine 137 Citations	The documentation of the presence of insulin resistance contributed substantially to unravel several metabolic components present in the syndrome.
Open access•Journal Article•DOI Magnesium deficiency and insulin resistance in patients with type 2 diabetes mellitus Maria de Lourdes Lima, Judith Maria Dias Carreiro Pousada, Cynara Gomes Barbosa, Thomaz Cruz - Show less +3 more 01 Dec 2005-Arquivos Brasileiros De Endocrinologia E Metabologia	Its deficiency may increase insulin resistance, especially in patients with metabolic syndrome or type 2 diabetes.
Open access•Journal Article•DOI Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention. Shaodong Guo 01 Feb 2014-Journal of Endocrinology 226 Citations	Overall, it is clear that insulin resistance in each organ differently contributes to the features of metabolic syndrome: Obesity is resulted from insulin resistance by the brain; hyperglycemia by the brain, pancreas, liver and fat; hyperlipidemia by the fat and brain; and hypertension by, at least, the vascular endothelial cells.
Journal Article•DOI The metabolic syndrome: insulin resistance. Nasser Mikhail 08 Mar 2009-Current Hypertension Reports 68 Citations	Insulin resistance may play an important role in the development of hyperglycemia and dyslipidemia, which can further aggravate insulin resistance.
Journal Article•DOI Hepatic insulin resistance, metabolic syndrome and cardiovascular disease Reza Meshkani, Khosrow Adeli - Show less +1 more 01 Sep 2009-Clinical Biochemistry 392 Citations	Overall, growing evidence suggests that hepatic insulin resistance is sufficient to induce several components of the metabolic syndrome and promote progression to cardiovascular disease.
Journal Article•DOI Insulin Resistance as the Underlying Cause for the Metabolic Syndrome D. Lann, Derek LeRoith - Show less +1 more 01 Nov 2007-Medical Clinics of North America 209 Citations	A more in-depth understanding of the basic pathophysiologic mechanisms underlying insulin resistance may aid clinicians in treating and possibly delaying or even preventing the onset of the metabolic syndrome and its complications.
Open access•Journal Article•DOI Central Obesity, the Metabolic Syndrome, and Plasminogen Activator Inhibitor-1 in Young Adults Susan J. Appel, Joanne S. Harrell, Marsha L. Davenport - Show less +2 more 01 Dec 2005-Journal of The American Academy of Nurse Practitioners 43 Citations	Furthermore, insulin resistance is believed to occur initially in the trajectory of the metabolic syndrome, making it a principal contender for suitable interventions to reduce risk for both type 2 diabetes and cardiovascular disease (CVD).
Open access•Journal Article [Insulin resistance: organ manifestations and cellular mechanisms]. Henning Beck-Nielsen 15 Apr 2002-Ugeskrift for Læger	Specifically, abdominal adiposity seems to be responsible for insulin resistance in subjects with the metabolic syndrome.
Journal Article•DOI Relative risks of the metabolic syndrome according to the degree of insulin resistance in apparently healthy Korean adults. Seung Ha Park, Won Young Lee, Eun-Jung Rhee, Woo-Kyu Jeon, Byung-Ik Kim, Seungho Ryu, Sun Woo Kim - Show less +6 more 01 Jun 2005-Clinical Science	These results show that the metabolic syndrome is significantly correlated with the insulin resistance index, and that appropriate values of HOMA and fasting insulin concentration may serve as a helpful guide for the management of metabolic syndrome.
Journal Article•DOI The metabolic syndrome. Alan J. Garber 01 Jul 2004-Medical Clinics of North America 42 Citations	Treatment for the metabolic syndrome should be focused primarily on modifying lifestyle,with reduction of the underlying obesity and insulin resistance.

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Related Questions

How to reverse diabetes naturally?5 answersTo reverse diabetes naturally, there are several approaches that can be considered. One approach is through the use of very-low-carbohydrate diets and intermittent fasting, as suggested by Fung. Another approach is the use of natural medicines, such as a preparation made from towel gourd seeds, which has shown to have a substantial blood sugar reduction effect. Additionally, adopting a healthy lifestyle program that includes proper eating habits, regular physical exercise, and avoiding tobacco use can help prevent and reverse diabetes. Herbal medicines have also been found to be effective in lowering blood glucose levels in patients with diabetes. Finally, natural modalities such as diet, physical activity, and common natural products have shown promise in supplementing current pharmacologic treatments for diabetes management.

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Plasma ceramides primarily originate from the liver in both animals and humans, as supported by various studies. Ceramides are sphingolipids that play crucial roles in cellular signaling and are involved in metabolic dysfunction, dyslipidemia, and inflammation. Elevated plasma ceramide levels, especially C16, C18, and C24:1, have been linked to unstable coronary artery disease and are considered emerging biomarkers for cardiovascular diseases. Furthermore, ceramides have been implicated in insulin resistance and β-cell failure, with diacylglycerols and fatty acyl-CoAs also contributing to dysregulation of cellular insulin signaling. The liver's de novo synthesis of ceramides in response to certain stimuli underscores its significance as a major source of plasma ceramides, highlighting the intricate relationship between ceramides and metabolic health.What is the historical significance of Palmyra in the treatment of diabetes?

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Alkaloids found in plants like Palmyra palm have shown potential in the treatment of diabetes. Research indicates that alkaloids possess antidiabetic properties. Specifically, compounds like Palmatine from certain plants have demonstrated antidiabetic, antioxidant, and protective effects against tissue damage. Additionally, alkaloids from Piper longum have exhibited anti-diabetic activity by inhibiting PTP1B and activating the PI3K/AKT pathway, promoting glucose metabolism. The mechanism of action of herbal antidiabetic alkaloids includes stimulating insulin secretion, reducing insulin resistance, and activating various metabolic pathways. These findings suggest that alkaloids present in plants like Palmyra palm could be beneficial in managing diabetes and its complications, offering a potential alternative or complementary approach to conventional treatments.What is hypertension and causes?

Hypertension, commonly known as high blood pressure, is a significant health disorder associated with various complications like cardiovascular diseases, stroke, and kidney failure. The causes of hypertension are multifactorial, including genetic predisposition, unhealthy diet, lack of physical activity, and aging-related factors. Additionally, secondary hypertension can be triggered by conditions such as renal diseases, primary hyperaldosteronism, and obstructive sleep apnea, among others, which account for about 10% of adult hypertension cases. Lifestyle modifications, weight management, and proper diagnosis and treatment of underlying conditions are crucial in managing hypertension effectively.Does foxo1 phosphorylated under obesity?

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Anthropometry is associated with blood pressure due to its role as a predictor of hypertension risk. Various anthropometric parameters like waist circumference, body mass index, waist-to-height ratio, and novel indices such as conicity index and body shape index have been shown to have significant associations with blood pressure levels. These measurements provide insights into the distribution of body fat, which is crucial in understanding the risk factors for cardiovascular diseases like hypertension. Additionally, studies emphasize the importance of managing anthropometric parameters to mitigate the rise of hypertension and diabetes mellitus, highlighting the critical role of anthropometry in cardiovascular health.How lifestyle factors is associated with blood pressure?

Lifestyle factors play a crucial role in influencing blood pressure levels. Studies have shown that various aspects of lifestyle, such as physical activity, diet, smoking habits, stress levels, and alcohol consumption, are significantly associated with hypertension. Engaging in regular physical activity, maintaining a healthy diet, abstaining from smoking and excessive alcohol consumption, and managing stress levels are all linked to better blood pressure control. Additionally, factors like body mass index (BMI), fasting blood glucose levels, serum uric acid levels, and genetic predisposition also impact blood pressure regulation. These findings underscore the importance of adopting a healthy lifestyle to prevent and manage hypertension effectively.What are the current scientific studies exploring the efficacy of Palmyra in managing diabetes?

Current scientific studies have explored the efficacy of Palmyra (Borassus flabellifer) in managing diabetes through various approaches. One study investigated the antidiabetic and antioxidant properties of immature Palmyra palm fruits, showing significant improvements in blood glucose levels and key metabolic enzymes in diabetic rats. Another study focused on the potential of palmitic acid from the Dandang gendis plant, which is found in Palmyra, as an AMPK protein activator to reduce blood sugar levels. Additionally, Palmyra fruit pulp has been shown to inhibit intestinal glucose uptake and reduce serum glucose levels in mild diabetic patients, indicating its potential as an anti-diabetic food component. These studies collectively highlight the promising role of Palmyra in diabetes management through its antidiabetic, antioxidant, and glucose-regulating properties.What type of diabetes is palmyra palm used to manage?

Palmyra palm, specifically the immature fruits of Borassus flabellifer, is traditionally used to manage type 2 diabetes. Studies have shown that the immature palmyra palm fruits possess antidiabetic properties. Additionally, Raffia palm wine, derived from Raphia hookeri, has been found to have therapeutic potential against the effects of type 2 diabetes, including oxidative testicular injury. Furthermore, research indicates that Raffia palm wine may offer neuroprotective benefits against diabetic neurodegeneration, highlighting its potential in managing complications of type 2 diabetes, such as neurodegenerative diseases like Alzheimer's. These studies collectively demonstrate the efficacy of palm-derived products in managing type 2 diabetes and its associated complications.What are the most common hyperglycemic disorders associated with diabetes?

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