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Open accessJournal Article
T Henriksen, M Endresen 
47 Citations
Possibly antioxidants can be used to limit oxidative stress.
Antioxidants show a substantial effect in human’s health since they can ameliorate aging by fighting free radicals.
Therefore, antioxidants that inhibit ROS generation can delay skin aging.
As the organism ages, production of reactive oxygen species (ROS) increases while antioxidants defense capability declines, leading to oxidative stress in critical cellular components, which further enhances ROS production.
Journal ArticleDOI
01 Jan 1991
82 Citations
Similarly, antioxidants can slow atherogenesis, caused in part by oxidative stress and free radicals.
When added to foods, antioxidants control rancidity development, retard the formation of toxic oxidation products, maintain nutritional quality, and extend the shelf-life of products.
Our results show that AGEs induce lipid peroxidation in a neuronal cell line in a dose-dependant manner, and that blocking the specific AGE-receptor RAGE, as well as using different antioxidants (alpha-lipoic acid, N-acetylcysteine, 17 beta-estradiol or aminoguanidine) can reduce the AGE-mediated formation of lipid peroxidation products.
The cytotoxic effects of AGEs could be attenuated by α-ketoglutarate and pyruvate, by antioxidants such as thioctic acid and N-acetylcysteine, and by aminoguanidine, an inhibitor of nitric oxide synthase.
Fortunately, antioxidants can obviate these effects through modification of gene expression, transcription factor signaling, and cell cycle alterations.

Related Questions

What is the relationship between age and enzymatic antioxidant levels in serum of hypertensive patients?5 answersThe relationship between age and enzymatic antioxidant levels in the serum of hypertensive patients is significant. Studies have shown that with advancing age, there is a notable decrease in enzymatic antioxidants in hypertensive individuals. Specifically, the levels of antioxidants such as glutathione (GSH) decrease significantly with age in both males and females. Additionally, research indicates that the percentage decrease in enzymatic antioxidants with age is higher in hypertensive patients compared to normotensive individuals. This decline in enzymatic antioxidants with age underscores the importance of considering age-related changes in the antioxidant defense system when managing hypertension. Understanding these age-dependent alterations in antioxidant levels can provide valuable insights for developing targeted interventions to mitigate oxidative stress in hypertensive patients as they age.
What are the effects of antioxidants on premature aging in skin care?5 answersAntioxidants have been shown to have beneficial effects on premature aging in skin care. They can protect the skin from damage caused by oxidation and prevent premature aging. Antioxidants, such as polyphenols, have been found to have antioxidant, anticarcinogenic, and neuroprotective effects when taken into the body in appropriate amounts. Reactive oxygen and nitrogen species (ROS/RNS), which contribute to aging processes, can be neutralized by antioxidants, thereby limiting damage to the skin. Combining natural antioxidants in skin care products can have a synergistic effect, resulting in greater overall benefits for the skin. In a clinical trial, the antioxidant SOD was found to significantly increase total antioxidant status (TAS), decrease transepidermal water loss (TEWL), and improve skin dryness in premature skin aging. These findings suggest that antioxidants can play an important role in preventing and reducing premature aging in the skin.
How do antioxidants work to neutralize free radicals?4 answersAntioxidants work to neutralize free radicals through various mechanisms. Firstly, antioxidants can inhibit the formation of free radicals by reducing their production. Secondly, antioxidants can capture free radicals, acting as radical scavengers. Thirdly, antioxidants can complex transition metal ions, which catalyze prooxidative processes. Additionally, antioxidants can protect cells from damage caused by free radicals by regulating ROS-related enzymes. Antioxidants can also capture free-radical reaction products, preventing the formation of radicals in living cells and subsequent events such as apoptosis. By performing these actions, antioxidants prevent or limit oxidative stress, which can lead to various conditions such as cardiovascular diseases, malignant diseases, immune system diseases, diabetes, and neurodegenerative diseases.
What is the relationship between oxidative stress and aging?4 answersOxidative stress is a key factor in the aging process. It is an imbalance between oxidants and antioxidants, leading to molecular damage and disruption of redox signaling. Various environmental toxins, such as air pollution, water contamination, and heavy metals, contribute to oxidative stress and accelerate aging. The effects of oxidative stress on aging include genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and altered intercellular communication. Mitochondrial dysfunction is particularly important in the aging process, as it is the primary source of reactive oxygen species (ROS). Elevated ROS levels can cause oxidative damage to cells, organelles, DNA, lipids, and proteins, contributing to the aging phenotype. Understanding and mitigating oxidative stress through interventions such as nutritional changes, exercise, and stem cell therapy may help prevent age-related diseases and promote healthy aging.
How we can use antioxidant to treat cancer deases?5 answersAntioxidants are used as adjuvant treatments during chemotherapy or radiotherapy for cancer patients. They help prevent oxidative stress, which is involved in the development and progression of cancer. However, the effects of antioxidants on cancer treatment are still not fully understood, and there are conflicting reports on their benefits and adverse effects. While antioxidants have been shown to have potential in preventing cancer and neutralizing free radicals, their role in cancer prevention and treatment is complex and context-dependent. It is important to rely on plant-derived food as a source of antioxidants rather than antioxidant supplements. Nanotechnology has also been explored to improve the delivery of antioxidants in cancer therapy, enhancing their therapeutic effects. Further research and clinical trials are needed to determine the efficacy and safety of antioxidants in cancer treatment.
How do antioxidants works against free radicals?3 answersAntioxidants work against free radicals by neutralizing them and preventing their harmful effects on the body. Free radicals are highly reactive molecules that can cause damage to cells and tissues by stealing electrons from other molecules. Antioxidants donate electrons to free radicals, stabilizing them and preventing them from causing further damage. Antioxidants can scavenge free radicals directly, activate antioxidant enzymes, chelate metal catalysts, and inhibit oxidases. They can also work by reducing the production of free radicals through dietary interventions such as caloric restriction and minimizing the intake of substances that increase free radicals. Enzymatic antioxidants such as superoxide dismutase, glutathione reductase, and catalase play a crucial role in neutralizing free radicals and protecting cells from their toxicity. Overall, antioxidants play an essential role in reducing free radicals and preventing their harmful effects on the body.

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