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How destruction of motor neurons by poliovirus or amyotrophic lateral sclerosis can be fatal?

Amyotrophic lateral sclerosis

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Open access•Journal Article•DOI Molecular Pathogenesis of Neural Lesions Induced by Poliovirus Type 1 Thérèse Couderc, Christina Christodoulou, Hélèna Kopecka, Susan Marsden, Leslie Frank Taffs, Radu Crainic, F. Horaud - Show less +6 more 01 Nov 1989-Journal of General Virology 44 Citations	Quantitative in situ hybridization provided evidence of viral replication in individual cells suggesting that the death of motor neurons was due to the direct effect of poliovirus replication in these cells.
Journal Article•DOI Targeted foreign gene expression in spinal cord neurons using poliovirus replicons Andrea W. Bledsoe, G Y Gillespie, Casey D. Morrow - Show less +2 more 01 Apr 2000-Journal of NeuroVirology 22 Citations	The lack of discernible neuronal destruction following replicon inoculation into the spinal cord suggests that some of the pathogenesis observed during a poliovirus infection might not be due entirely to primary infection of neurons.
Journal Article•DOI Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease Nigel Swanson, Simon A. Fox, Frank L. Mastaglia - Show less +2 more 01 Nov 1995-Neuromuscular Disorders 31 Citations	A longstanding hypothesis proposes that amyotrophic lateral sclerosis-motor neurone disease (ALS-MND) is a late consequence of subclinical poliovirus (PV) infection.
Open access•Journal Article•DOI Viral-Induced Spinal Motor Neuron Death Is Non-Cell-Autonomous and Involves Glutamate Excitotoxicity Jessica Darman, Stephanie Backovic, Sonny Dike, Nicholas J. Maragakis, Chitra Krishnan, Jeffrey D. Rothstein, David N. Irani, Douglas A. Kerr - Show less +7 more 25 Aug 2004-The Journal of Neuroscience 106 Citations	Similar changes may occur in other motor neuron disorders such as amyotrophic lateral sclerosis or West Nile Virus-induced poliomyelitis, suggesting a common tissue injury pathway.
Journal Article•DOI Cell-mediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis. Edna Kott, Ella Livni, Rina Zamir, Arieh Kuritzky - Show less +3 more 01 Jul 1979-Neurology 29 Citations	These findings suggest a strong linkage between HLA-A3 and poliovirus in the pathogenesis of amyotrophic lateral sclerosis.
Journal Article•DOI Regular involvement of Clarke's nucleus in sporadic amyotrophic lateral sclerosis. Paul Averback, Paul Crocker - Show less +1 more 01 Mar 1982-JAMA Neurology 78 Citations	The process seems likely to be similar to that affecting motor neurons but is less advanced at the time of death.

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Related Questions

Does ALS affect both upper motor neurons and lower motor neurons?5 answersYes, amyotrophic lateral sclerosis (ALS) affects both upper motor neurons (UMN) and lower motor neurons (LMN). ALS is a neurodegenerative disease characterized by the degeneration of UMN in the motor cortex and LMN in the brainstem and spinal cord. The degeneration of these two neuronal populations is somatotopically related, meaning that the affected regions are connected. In ALS, UMN degeneration is an early event that precedes LMN degeneration. The diagnosis of ALS requires recognition of both UMN and LMN dysfunction. Electromyography (EMG) is used to detect LMN involvement, while there are no generally accepted markers for monitoring UMN abnormalities. Therefore, a full clinical assessment is necessary to diagnose ALS and monitor disease progression.

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